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Encyclopedia > Diflunisal

Diflunisal chemical structure

IUPAC name
CAS number
ATC code
Chemical formula C13H8F2O3
Molecular weight 250.0442
Bioavailability 80-90%
Metabolism Liver
Elimination half life 8-12 hours
Excretion Urine
Pregnancy category C
Legal status USA DEA Schedule IV
Route of administration Oral
Indicated for:
  • Arthritis
  • Injury to tendons
  • Inflammation

IUPAC nomenclature is a systematic way of naming organic chemical compounds as recommended by the International Union of Pure and Applied Chemistry (IUPAC). ... CAS registry numbers are unique numerical identifiers for chemical compounds, polymers, biological sequences and alloys. ... The Anatomical Therapeutic Chemical Classification System is used for the classification of drugs. ... A section of the Anatomical Therapeutic Chemical Classification System. ... A chemical formula (also called molecular formula) is a concise way of expressing information about the atoms that constitute a particular chemical compound. ... The molecular mass of a substance (less accurately called molecular weight and abbreviated as MW) is the mass of one molecule of that substance, relative to the unified atomic mass unit u (equal to 1/12 the mass of one atom of carbon-12). ... In pharmacology, bioavailability is used to describe the fraction of an administered dose of medication that reaches the systemic circulation, one of the principal pharmacokinetic properties of drugs. ... Half-Life is a science fiction first-person shooter computer game developed by Valve Software and published by Sierra Entertainment in 1998, based on a heavily-modified Quake game engine. ... Excretion is the biological process by which an organism chemically separates waste products from its body. ... The pregnancy category of a pharmaceutical agent is an assessment of the risk of fetal injury due to the pharmaceutical, if it is used as directed by the mother. ... The Controlled Substances Act (CSA), Title II of the Comprehensive Drug Abuse Prevention and Control Act of 1970, is the legal foundation of the United States governments fight against the abuse of drugs and other substances. ... The Controlled Substances Act (CSA), Title II of the Comprehensive Drug Abuse Prevention and Control Act of 1970, is the legal foundation of the United States governments fight against the abuse of drugs and other substances. ...

  • This medication has no side effects like thoughs of recreational drugs
Side effects:

Cardiovascular: A side-effect is any effect other than an intended primary effect. ... The circulatory system or cardiovascular system is the organ system which circulates blood around the body of most animals. ...

  • Irregular heart beat (!)

Ear, nose, and throat: An ear is an organ used by an animal to detect sound waves. ... Human nose in profile The Nose is a story by Gogol and an opera by Dmitri Shostakovich. ... Anatomy In anatomy, the throat is the part of the neck anterior to the vertebral column. ...

  • Ringing in the ears (!)

Eye: This article needs to be cleaned up to conform to a higher standard of quality. ...

  • Yellowing of eyes (!)

Gastrointestinal: For the Physics term GUT, please refer to Grand unification theory The gastrointestinal or digestive tract, also referred to as the GI tract or the alimentary canal or the gut, is the system of organs within multicellular animals which takes in food, digests it to extract energy and nutrients, and...

  • Stomach pain and cramps
  • Constipation
  • Gas
  • Diarrhea
  • Vomiting

Central Nervous System: A diagram showing the CNS. The central nervous system (CNS) represents the largest part of the nervous system. ...

  • Drowsiness
  • Dizziness
  • Headache

Psychiatric: Psychiatry is a branch of medicine that studies and treats mental and emotional disorders (see mental illness). ...

  • Nervousness

Skin: Model of the layers of human skin In zootomy and dermatology, skin is an organ of the integumentary system; which is composed of a layer of tissues that protect underlying muscles and organs. ...

  • Swelling of the feet, ankles, lower legs, and hands (!)
  • Yellowing of skin (!)


  • If symptoms labeled, (!), appear, stop useage immediately and contact your doctor.
  • Overdose is possible and deaths have occured.
  • Do not take while on other pain medications.
  • Do not take while pregnant or breast feeding.

Diflunisal is a generic NSAID (Non Steroidal Anti Inflammatory Drug). It is often used under the brand name Dolobid®. Diflunisal acts by inhibiting the production of prostaglandin, a hormone that creates inflammation and stimulates the neuro receptors for pain. Though Diflunisal has an onset of 1 hour, and maximum analgesia at 2 to 3 hours, the diflunisal plasma levels will not be steady until repeated doesages are achieved. To increase the rate at which the diflunisal plasma levels become steady, a loading dose is usually used. It is primarily used to treat symptoms of arthritis. A generic drug (pl. ... Non-steroidal anti-inflammatory drugs, usually abbreviated to NSAIDs, are drugs with analgesic, antipyretic and anti-inflammatory effects - they reduce pain, fever and inflammation. ... A prostaglandin is any member of a group of lipid compounds that are derived from fatty acids and have important functions in the animal body. ... For other uses of painkiller, see painkiller (disambiguation) An analgesic (colloquially known as painkiller) is any member of the diverse group of drugs used to relieve pain. ... Arthritis (from Greek arthro-, joint + -itis, inflammation) is a group of conditions that affect the health of the bone joints in the body. ...


Deaths that have occurred from Diflunisal usually involved mixed drugs and or extremely high dosages. The oral LD50 is 500mg/kg. Symptoms of overdose include, coma, tachycardia, stupor, and vomiting. The lowest dose without the presence of other medicines which caused death was 15 grams. Mixed with other medicines, a death at 7.5 grams has also occurred. Diflunisal usually comes in 250 or 500mg, thus it is relatively hard to overdose by accident. An LD50 test being administered In toxicology, the LD50 or colloquially semilethal dose of a particular substance is a measure of how much constitutes a lethal dose. ... Tachycardia is an abnormally rapid beating of the heart, defined as a resting heart rate of over 100 beats per minute. ...

External Links

  • http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a684037.html
  • http://www.medsafe.govt.nz/Profs/Datasheet/discontinued/ansaltab.htm

Analgesics edit

{Paracetamol (acetaminophen)} {NSAIDs} {Opiates} {Tetrahydrocannabinol} {Ketamine} An analgesic (colloquially known as painkiller) is any member of the diverse group of drugs used to relieve pain and to achieve analgesia. ... Paracetamol (INN) or acetaminophen (USAN) is a popular analgesic and antipyretic drug that is used for the relief of fever, headaches, and other minor aches and pains. ... Wikipedia does not yet have an article with this exact name. ... An opioid is any agent that binds to opioid receptors found principally in the central nervous system and gastrointestinal tract. ... THC can also refer to the Thermohaline circulation Tetrahydrocannabinol, also known as THC, Δ9-THC, Δ9-tetrahydrocannabinol (delta-9-tetrahydrocannabinol), Δ1-tetrahydrocannabinol (using an older numbering scheme), or dronabinol, is the main psychoactive substance found in the Cannabis plant. ... Ketamine is a general dissociative anaesthetic for human and veterinary use. ...

NSAIDs edit

{Aspirin} {Celecoxib} {Diclofenac} {Diflunisal} {Ibuprofen} {Ketoprofen} {Ketorolac} {Meloxicam} {Naproxen} {Rofecoxib} {Indomethacin} Non-steroidal anti-inflammatory drugs, usually abbreviated to NSAIDs, are drugs with analgesic, antipyretic and anti-inflammatory effects - they reduce pain, fever and inflammation. ... Aspirin or acetylsalicylic acid is a drug in the family of salicylates, often used as an analgesic (against minor pains and aches), antipyretic (against fever), and anti-inflammatory. ... Celecoxib is a non-steroidal anti-inflammatory drug (NSAID) used in the treatment of osteoarthritis, rheumatoid arthritis, acute pain, painful menstruation and menstrual symptoms, and to reduce numbers of colon and rectum growths polyps in patients with familial adenomatous polyposis. ... Diclofenac (marketed as Voltaren®, Voltarol® and Cataflam®) is a non-steroidal anti-inflammatory drug (NSAID) taken to reduce inflammation, such as in arthritis or acute injury. ... Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) widely marketed under various trademarks including Act-3, Advil, Brufen, Motrin, Nuprin, and Nurofen; a standing joke about some athletes regular use has produced Vitamin I as a slang term for it. ... Ketoprofen, 2-(3-benzoylphenyl)-propionic acid (chemical formula C12H12O2) is one of the propionic acid class of non-steroidal anti-inflammatory drug (NSAID) with additional analgesic and anti-pyretic effects. ... Ketorolac or ketorolac tromethamine (marketed as Toradol® - generics have been approved) is a non-steroidal anti-inflammatory drug (NSAID) in the family of propionic acids, often used as an analgesic, antipyretic (fever reducer), and anti-inflammatory. ... Meloxicam is a nonsteroidal anti-inflammatory drug used to relieve the symptoms of arthritis, primary dysmenorrhoea, pyrexia; and as an analgesic, especially where there is an inflammatory component. ... Naproxen (trade names: Aleve, Anaprox, Naprosyn, Naprelan) is a non-steroidal anti-inflammatory drug (NSAID) commonly used for the reduction of mild to moderate pain, fever, inflammation and stiffness caused by conditions such as osteoarthritis, rheumatoid arthritis, psoriatic arthritis, gout, ankylosing spondylitis, injury, menstrual cramps, tendinitis, bursitis, and the treatment... Rofecoxib is a nonsteroidal anti-inflammatory drug (NSAID) that was used in the treatment of osteoarthritis, acute pain conditions, and dysmenorrhoea. ... Indomethacin (also indometacin) is a non-steroidal anti-inflammatory drug commonly used to reduce fever, pain, stiffness, and swelling. ...

Opioids edit

{Alfentanil} {Buprenorphine} {Carfentanil} {Codeine} {Codeinone} {Dextropropoxyphene} {Dihydrocodeine} {Fentanyl} {Heroin} {Hydrocodone} {Hydromorphone} {Methadone} {Morphine} {Morphinone} {Oxycodone} {Oxymorphone} {Pethidine (Meperidine)} {Remifentanil} {Sufentanil} {Tramadol} An opioid is any agent that binds to opioid receptors found principally in the central nervous system and gastrointestinal tract. ... Alfentanil (Alfenta) is a parenteral short-acting opioid painkiller, used for anaesthesia in surgery. ... Buprenorphine, also colloquially referred to as bupe, is an opioid drug with partial agonist and antagonist actions. ... Carfentanil, also Carfentanyl, is an analogue of the popular opioid Fentanyl, and is currently the most potent opioid known [Actually Ohmefentanil is 13,000X morphine]. It has a quantitative potency approximately 10,000 times that of morphine and 100 times that of fentanyl (activity in humans starting at about 1... Codeine (INN) is an opioid used for its analgesic, antitussive and antidiarrheal properties. ... Codeinone is a strong Opiod. ... Dextropropoxyphene is an analgesic in the opioid category. ... penis ... Fentanyl is an opioid analgesic, first synthesized in Belgium in the late 1950s, with an analgesic potency of about 80 times that of morphine. ... Heroin or diacetylmorphine (INN) is an semi-synthetic opioid. ... Hydrocodone or dihydrocodeinone (marketed as Vicodin, Anexsia, Dicodid, Hycodan, Hycomine, Lorcet, Lortab, Norco, Tussionex, Vicoprofen) is an opioid derived from either of the naturally occurring opiates - codeine or thebaine. ... // Overview Hydromorphone is a drug used to relieve moderate to severe pain. ... Methadone is a synthetic opioid analgesic synthesized in 1937 by German scientists Max Bockmühl and Gustav Ehrhart at IG Farben (Hoechst-Am-Main) who were searching for an analgesic that would be easier to use during surgery and also have low addiction potential. ... Morphine (INN), the principal active agent in opium, is a powerful opioid analgesic drug. ... Morphinone is a very strong Opiod. ... Oxycodone is a very powerful and potentially addictive opioid analgesic medication synthesized from thebaine. ... Oxymorphone is a powerful synthetic narcotic analgesic drug that is similar to morphine. ... Pethidine (INN) or meperidine (USAN) (also referred to as: isonipecaine; lidol; operidine; pethanol; piridosal; Algil®; Alodan®; Centralgin®; Demerol®; Dispadol®; Dolantin®; Dolestine®; Dolosal®; Dolsin®; Mefedina®) is a fast-acting opioid analgesic drug. ... Remifentanil is a short-acting opioid analgesic drug, given to patients during surgery to relieve pain and as a complement to an anaesthetic. ... Sufentanil is a drug that belongs to the class of drugs known as the opioid analgesic drugs. ... Tramadol is an opioid used as an analgesic for treating moderate to severe pain. ...

  Results from FactBites:
diflunisal - Arthritis and arthritic conditions, medications, and treatment on MedicineNet.com (619 words)
PRESCRIBED FOR: Diflunisal is used for the treatment of inflammation and pain that results from many forms of arthritis, including rheumatoid arthritis and osteoarthritis, as well as soft tissue injuries, such as tendinitis, and bursitis.
Diflunisal is immediately released into the blood and is also used for rapid relief of mild to moderate pain and menstrual cramps.
Diflunisal is generally used with caution in patients taking blood thinning medications (anticoagulants), such as warfarin (Coumadin), because of increased risk of bleeding.
Diflunisal patient advice including side effects (787 words)
Diflunisal, a nonsteroidal anti-inflammatory drug, is used to treat mild to moderate pain and relieve the inflammation, swelling, stiffness, and joint pain associated with rheumatoid arthritis and osteoarthritis (the most common form of arthritis).
Diflunisal should be taken with food or food together with an antacid, and with a full glass of water or milk.
Diflunisal may cause you to become drowsy or less alert; therefore, driving or operating dangerous machinery or participating in any hazardous activity that requires full mental alertness is not recommended.
  More results at FactBites »



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