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Encyclopedia > Detoxification

Detox, short for detoxification, in general is the removal of toxic substances from the body. It is one of the major functions of the liver, lower gastrointestinal tract and kidneys, but can also be achieved artificially by techniques such as dialysis and (in a very limited number of cases) chelation therapy. Toxic redirects here, but this is also the name of a song by Britney Spears; see Toxic (song) Look up toxic and toxicity in Wiktionary, the free dictionary. ... For the bird, see Liver bird. ... The gastrointestinal tract (GI tract), also called the digestive tract, alimentary canal, or gut, is the system of organs within multicellular animals that takes in food, digests it to extract energy and nutrients, and expels the remaining waste. ... Kidneys viewed from behind with spine removed The kidneys are bean-shaped excretory organs in vertebrates. ... In medicine, dialysis is a type of renal replacement therapy which is used to provide an artificial replacement for lost kidney function due to renal failure. ... Chelation therapy is the administration of chelating agents to remove heavy metals from the body. ...


Types of detoxification

Alcohol detoxification

Main article: Alcohol detoxification

Alcohol detoxification is used as a form of drug rehabilitation to treat alcoholism or other drug addiction. The process involves abstinence to clear the drug from the body, accompanied by social and environmental support during the associated physiological and psychological changes. Alcohol detoxification or detox for alcoholics is an abrupt stop of alcohol drinking coupled with the substitution of drugs that have similar effects in order to prevent alcohol withdrawal. ... This article or section does not cite any references or sources. ... Alcoholism is the consumption of, or preoccupation with, alcoholic beverages to the extent that this behavior interferes with the drinkers normal personal, family, social, or work life, and may lead to physical or mental harm. ... Drug addiction, or dependency is the compulsive use of drugs, to the point where the user has no effective choice but to continue use. ...

Metabolic detoxification

An animal's metabolism can produce harmful substances which it can then make less toxic through oxidation, conjugation and excretion of molecules from cells or tissues. Enzymes that are important in detoxification metabolism include cytochrome P450 oxidases,[1] UDP-glucuronosyltransferasess,[2] and glutathione S-transferases.[3] These processes are particularly well-studied as part of drug metabolism, as they influence the pharmacokinetics of a drug in the body. Structure of the coenzyme adenosine triphosphate, a central intermediate in energy metabolism. ... Illustration of a redox reaction Redox (shorthand for oxidation/reduction reaction) describes all chemical reactions in which atoms have their oxidation number (oxidation state) changed. ... Conjugation may refer to: Grammatical conjugation, the modification of runnign a verb from its basic form Latin conjugation, Spanish conjugation and The English verb, each with complex conjugation forms Marriage, relationship between two individuals In mathematics: Complex conjugation, the operation which multiplies the imaginary part of a complex number by... The kidneys are important excretory organs in vertebrates. ... Structure of the coenzyme adenosine triphosphate, a central intermediate in energy metabolism. ... Cytochrome P450 Oxidase (CYP2E1) Cytochrome P450 oxidase (commonly abbreviated CYP) is a generic term for a large number of related, but distinct, oxidative enzymes (EC 1. ... Uridine 5-diphospho-glucuronosyltransferase (UDP-glucuronosyltransferase, UGT) is a naturally-occurring enzyme (EC 2. ... This article or section is in need of attention from an expert on the subject. ... Drug metabolism is the metabolism of drugs, their biochemical modification or degradation, usually through specialized enzymatic systems. ... Pharmacokinetics (in Greek: pharmacon meaning drug, and kinetikos meaning putting in motion) is a branch of pharmacology dedicated to the determination of the fate of substances administered externally to a living organism. ...

Alternative medicine

Certain approaches in alternative medicine claim to remove toxins from the body through herbal, electrical or electromagnetic treatments (such as the Aqua Detox treatment). These toxins are undefined and have little scientific basis, making the validity of such techniques questionable. There is no evidence for toxic accumulation in these cases, as the liver and kidneys automatically detoxify and excrete many toxic materials including metabolic wastes. Under this theory if toxins are too rapidly released without being safely eliminated (such as burning fat that stores toxins) they can damage the body and cause malaise. Alternative medicine is defined as any of various systems of healing or treating disease (as chiropractic, homeopathy, or faith healing) not included in the traditional medical curricula taught in the United States and Britain.[1] Complementary medicine is defined as any of the practices (as acupuncture) of alternative medicine accepted... Aqua Detox is an therapy based on the research of the medical scientist Dr. Royal Rife. ... For other uses, see Toxin (disambiguation). ... Structure of the coenzyme adenosine triphosphate, a central intermediate in energy metabolism. ... Malaise is a feeling of general discomfort or uneasiness, an out of sorts feeling, often the first indication of an infection or other disease. ...

Diet detoxification

Main article: Detox diet

Certain diets have an underlying assumption that the body accumulates toxins that must be removed, especially after periods of over-eating or the consumption of non-nutritious and processed foods. As with alternative medicine, the 'toxins' removed are undefined and are ascribed to foods, the environment and the body's own wastes. A detox diet is a dietary regimen involving a change in consumption habits in an attempt to detoxify the body by removal of toxins or other contaminants. ... Measuring body weight on a scale Dieting is the practice of ingesting food in a regulated fashion to achieve a particular objective. ... For other uses, see Toxin (disambiguation). ... The Nutrition Facts table indicates the amounts of nutrients which experts recommend you limit or consume in adequate amounts. ... Food processing is the set of methods and techniques used to transform raw ingredients into food for consumption by humans or animals. ...

Evian and marketing

In 2004, Evian began to use the term 'detox' to market and sell their bottled water. Taglines included "Detox with Evian," "Evian. Detox," "Evian - Your natural detox," and "Drink at least 1.5L of Evian every day to help cleanse your system inside out." The marketing campaign has included a five-step process aimed at personal health. Although the first step advocates drinking any kind of water, the company claimed their particular water was particularly efficacious because it was filtered through a "mineral-rich Alpine region." There is no consensus among health experts that Evian is healthier than any other type of processed potable water.[citation needed] Country France Source Évian-les-Bains Type still pH 7. ... A tagline is a variant of a branding slogan typically used in marketing materials and advertising. ... Alpine may refer to: Alpine, a breed of goat. ... Drinking water Mineral Water Drinking water is water that is intended to be ingested by humans. ...

Methods of detoxification

Drug detox is performed in many different ways depending on where one decides to receive treatment. Most drug detox centers simply provide treatment to avoid physical withdrawal to alcohol & other drugs. Ideally, a trained detox facility will incorporate counseling and therapy during detox to help with the psychological distress that the individual may experience as well. Less conventional methods for eliminating toxic substances from the body include the modification of the diet and addition of certain herbs and rituals such as colon hydrotherapy, body cleansing, juice fasting, and saunas. Colon hydrotherapy, also known as colonic irrigation, is an alternative medicine form of body cleansing, sometimes associated with naturopathy. ... Body cleansing or detoxification underpins many alternative medical treatments. ... A sauna, the wet version also called steam bath, is a small room or house designed as a place to experience dry or wet/dry heat sessions, or an establishment with one or more of these and auxiliary facilities, or the act of using a sauna. ...

See also

Body cleansing or detoxification underpins many alternative medical treatments. ... Water fasting is a type of fasting in which the practitioner consumes only water when they are thirsty. ... A xenobiotic is a chemical which is found in an organism but which is not normally produced or expected to be present in it. ...


  1. ^ Danielson P (2002). "The cytochrome P450 superfamily: biochemistry, evolution and drug metabolism in humans". Curr Drug Metab 3 (6): 561-97. PMID 12369887. 
  2. ^ King C, Rios G, Green M, Tephly T (2000). "UDP-glucuronosyltransferases". Curr Drug Metab 1 (2): 143-61. PMID 11465080. 
  3. ^ Sheehan D, Meade G, Foley V, Dowd C (2001). "Structure, function and evolution of glutathione transferases: implications for classification of non-mammalian members of an ancient enzyme superfamily". Biochem J 360 (Pt 1): 1–16. PMID 11695986. 

  Results from FactBites:
Alcohol Detoxification. Alcoholism. Detoxification Center (1346 words)
However, for individuals with physiologic substance dependence, detoxification is usually related to withdrawal syndrome, that is, the predictable constellation of signs and symptoms following abrupt discontinuation of, or rapid decrease in, intake of a substance that has been used consistently for a period of time.
Advantages of inpatient detoxification are that (1) the patient is in a protected setting where access to substances of abuse is restricted, (2) the management and monitoring of neural recovery eliminates craving, and allows a detoxification without withdrawal, and (3) detoxification can be accomplished more rapidly than it can in an outpatient setting.
Besides, detoxification with hospitalization prepares the patient for ongoing treatment of his or her dependence on alcohol or other drugs.
  More results at FactBites »



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