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Encyclopedia > Desipramine

Desipramine chemical structure
Desipramine Image File history File links Desipramine. ...


IUPAC name
CAS number
50-47-5
ATC code
N06AA01
PubChem
2995
DrugBank
APRD00022
Chemical formula C18H22N2
Molecular weight 266.381
Bioavailability 73-92%
Metabolism Hepatic
Elimination half-life 21-23 hours
Excretion Renal
Pregnancy category
Legal status Rx only
Routes of administration oral

Desipramine is a tricyclic antidepressant (TCA) that inhibits the reuptake of norepinephrine. It is sold under the brand names Norpramin® and Pertofrane®. It is used to treat depression, but not considered a first line treatment since the introduction of SSRI antidepressants. Desipramine is an active metabolite of imipramine. IUPAC nomenclature is a system of naming chemical compounds and of describing the science of chemistry in general. ... CAS registry numbers are unique numerical identifiers for chemical compounds, polymers, biological sequences and alloys. ... The Anatomical Therapeutic Chemical Classification System is used for the classification of drugs. ... A section of the Anatomical Therapeutic Chemical Classification System. ... PubChem is a database of chemical molecules . ... DrugBank is a database available at the University of Alberta that provides information about thousands of products. ... A chemical formula (also called molecular formula) is a concise way of expressing information about the atoms that constitute a particular chemical compound. ... The molecular mass of a substance (less accurately called molecular weight and abbreviated as MW) is the mass of one molecule of that substance, relative to the unified atomic mass unit u (equal to 1/12 the mass of one atom of carbon-12). ... In pharmacology, bioavailability is used to describe the fraction of an administered dose of medication that reaches the systemic circulation, one of the principal pharmacokinetic properties of drugs. ... Santorio Santorio (1561-1636) in his steelyard balance, from Ars de statica medecina, first published 1614 Metabolism (from μεταβολισμος (metabolismos)) is the biochemical modification of chemical compounds in living organisms anggjgjhnd cell (b). ... The liver is an organ in vertebrates including humans. ... The elimination half-life of a drug (or any xenobiotic agent) refers to the timecourse necessary for the quantity of the xenobiotic agent in the body (or plasma concentration) to be reduced to half of its original level through various elimination processes. ... Excretion is the biological process by which an organism chemically separates waste products from its body. ... Kidneys viewed from behind with spine removed The kidneys are bean-shaped excretory organs in vertebrates. ... The pregnancy category of a pharmaceutical agent is an assessment of the risk of fetal injury due to the pharmaceutical, if it is used as directed by the mother. ... The regulation of therapeutic goods, that is drugs and therapeutic devices, varies by jurisdiction. ... Chemical structure of the tricyclic antidepressant amitriptyline Tricyclic antidepressants are a class of antidepressant drugs first used in the 1950s. ... Norepinephrine or noradrenaline is a catecholamine and a phenethylamine with chemical formula C8H11NO3. ... Clinical depression is a state of sadness or melancholia that has advanced to the point of being disruptive to an individuals social functioning and/or activities of daily living. ... SSRI is an acronym that stands for several things: It is a class of antidepressants called selective serotonin reuptake inhibitor SSRI also is used as the stock symbol for Silver Standard Resources Inc. ... An antidepressant is a medication used primarily in the treatment of clinical depression. ... A metabolite is the product of metabolism. ... Imipramine (tradenames: Janimine®, Tofranil®) is an antidepressant medication belonging to a class called tricyclic antidepressants of the dibenzazepine group, mainly used in the treatment of clinical depression and enuresis. ...


Along with other tricyclics, desipramine has found use in treating neuropathic pain. The mechanism of action seems to involve the activation, through norepinephrine reuptake inhibition, of descending pathways in the spinal cord that block pain signals from ascending to the brain. Desipramine is one of the most potent and selective medications in this respect. Neuropathy is a disease of the peripheral nervous system. ...


Some evidence suggests that desipramine may help with ADD. ADD can refer to several topics: Attention-deficit hyperactivity disorder - a neuropsychological disorder Attribute Driven Design - a software architecture design method The IATA airport code for Bole International Airport in Addis Ababa, Ethiopia The National Rail code for Adderley Park railway station, United Kingdom. ...


See also

An antidepressant is a medication designed to treat or alleviate the symptoms of clinical depression. ... Chemical structure of the tricyclic antidepressant amitriptyline Tricyclic antidepressants are a class of antidepressant drugs first used in the 1950s. ...

External links

  • Desipramine - medicinenet.com
  • Desipramine - medlineplus.org


Antidepressants (ATC N06A) edit
Monoamine oxidase inhibitors: {Harmaline} {Nialamide} {Selegiline} {Isocarboxazid} {Iproniazid} {Iproclozide} {Moclobemide} {Phenelzine} {Toloxatone} {Tranylcypromine}

Dopamine reuptake inhibitors: {Bupropion} {Amineptine} {Methylphenidate} {Phenmetrazine} {Vanoxerine} An antidepressant is a medication designed to treat or alleviate the symptoms of clinical depression. ... A section of the Anatomical Therapeutic Chemical Classification System. ... Monoamine oxidase inhibitors (MAOIs) are a class of antidepressant drugs prescribed for the treatment of depression. ... Harmala, also known at various times as Telepathine and Banisterine, is a blanket term for a group of naturally occurring beta-carbolines including harmine, harmaline, and others. ... Nialamide (Espril®, Niamid®, Niaquitil®, Nuredal®, Nyazin®, and Psicodisten®) was one of the first MAOI (monoamine oxidase inhibitor) antidepressants. ... Selegiline (l-deprenyl, Eldepryl® or Anipryl® [veterinary]) is a drug used for the treatment of early-stage Parkinsons disease and senile dementia. ... Isocarboxazid is a nonselective hydrazine-derived monoamine oxidase inhibitor used in treatment resistant depression. ... Iproniazid is a monamine oxidase inhibitor (MAOI) that was developed as the first anti-depressant (Also first psychiatric drug). ... Moclobemide (sold as Aurorix®, Manerix®) is a psychiatric drug primarily used to treat depression and social anxiety. ... Phenelzine (brand name Nardil) is an antidepressant drug that belongs to the monoamine oxidase inhibitor (MAOI) class of drugs. ... Tranylcypromine is an antidepressant drug. ... Dopamine Reuptake Inhibitors or Dopamine Uptake Inhibitors are compounds that inhibit the reuptake of the neurotransmitter dopamine after it is released and used at the synapse. ... Bupropion (amfebutamone) (brand names Wellbutrin and Zyban) is an antidepressant of the aminoketone class, chemically unrelated to tricyclics or selective serotonin reuptake inhibitors (SSRIs). ... Amineptine is an atypical tricyclic antidepressant that selectively inhibits the reuptake of dopamine and to a lesser extent norepinephrine, thus exerting a powerful and fast-acting antidepressant effect. ... Methylphenidate (MPH) is an amphetamine-like prescription stimulant commonly used to treat Attention Deficit Hyperactivity Disorder (ADHD) in children and adults. ... Phenmetrazine is an amphetamine-like drug. ... Vanoxerine, also known as GBR-12909, is a piperazine derivative which is a potent and selective dopamine reuptake inhibitor. ...


Norepinephrine reuptake inhibitors: {Atomoxetine} {Reboxetine} {Viloxazine} {Maprotiline} Norepinephrine reuptake inhibitors (NRIs) are compounds that increase amounts of the neurotransmitter norepinephrine in the brain by inhibiting its reuptake at synapses. ... Atomoxetine is a drug used in the treatment of attention-deficit hyperactivity disorder (ADHD). ... Reboxetine is an antidepressant drug used in the treatment of clinical depression, panic disorder and ADD/ADHD. Its mesilate ( methanesulfonate) salt is sold under tradenames including Edronax®, Norebox®, Prolift®, Solvex® or Vestra®. Reboxetine has two chiral centers, but it only exists as two enantiomers, (R,R)-(-)- and (S,S)-(+)-reboxetine. ... Viloxazine is a bicyclic antidepressants[2] that inhibits the reuptake of serotonin, and to a lesser extent, dopamine and norepinephrine. ... To meet Wikipedias quality standards, this article may require cleanup. ...


Serotonin-norepinephrine reuptake inhibitors: {Desipramine} {Duloxetine} {Milnacipran} {Nefazodone} {Venlafaxine} Serotonin-norepinephrine reuptake inhibitors (SNRIs) are a class of antidepressant used in the treatment of clinical depression and other affective disorders. ... Duloxetine hydrochloride (brand names: Cymbalta/Yentreve) is a medically used drug that primarily targets major depressive disorders (MDD), pain related to diabetic peripheral neuropathy and stress urinary incontinence (SUI). ... Milnacipran is an antidepressant of the serotonin-norepinephrine reuptake inhibitor class. ... // Introduction Serzone (nefazodone) Serzone ( Nefazodone HCl ) is an antidepressant drug formerly marketed by Bristol-Myers Squibb. ... Venlafaxine hydrochloride is a synthetic derivative of phenethylamine and a prescription antidepressant first introduced by Wyeth in 1993, and marketed under the trade names Effexor® for tablets and Effexor XR® for extended-release capsules. ...


Selective serotonin reuptake inhibitors: {Alaproclate} {Etoperidone} {Citalopram} {Escitalopram} {Fluoxetine} {Fluvoxamine} {Paroxetine} {Sertraline} {Zimelidine} Selective serotonin reuptake inhibitors (SSRIs) are a class of antidepressants for treating depression, anxiety disorders and some personality disorders. ... Citalopram or nitalapram is an antidepressant drug used to treat the depression associated with mood disorders. ... Escitalopram is a medication developed by the Danish pharmaceutical company Lundbeck, that acts as a selective serotonin reuptake inhibitor or SSRI. It is typically used as an antidepressant to treat depression associated with mood disorders although also may be used in the treatment of body dysmorphic disorder and anxiety. ... Fluoxetine hydrochloride is an antidepressant drug used medically in the treatment of depression, obsessive-compulsive disorder, bulimia nervosa, premenstrual dysphoric disorder and panic disorder. ... Fluvoxamine maleate (sold under the brand-names Luvox® and Faverin®) is a selective serotonin reuptake inhibitor. ... Paroxetine or paroxetine hydrochloride (sold as Paxil® in the United States and Canada; Seroxat® in Austria, Poland, the UK and China; Aropax® in Australia, New Zealand and Brazil; Pondera® in Brazil; Deroxat® in Switzerland and France; Paroxat® in Germany, and Cebrilin in Latin America) is a selective serotonin reuptake inhibitor... Sertraline hydrochloride (Zoloft®, Sertralin®, Lustral®, Apo-Sertral®, Asentra®, Gladem®, Serlift®, Stimuloton®, Xydep®, Serlain®, Concorz®) is an orally administered antidepressant of the selective serotonin reuptake inhibitor (SSRI) type. ... // General Remars and History Zimelidine is a pyridylallylamine and has a structure different from other antidepressants. ...


Selective serotonin reuptake enhancers: {Tianeptine} Tianeptine (INN) (Stablon®, Coaxil®, Tatinol®), is structurally similar to the tricyclic antidepressants. ... Tianeptine (INN) (Stablon®, Coaxil®), is structurally similar to the tricyclic antidepressants. ...


Tricyclic antidepressants: {Amitriptyline} {Clomipramine} {Desipramine} {Dothiepin} {Doxepin} {Imipramine} {Lofepramine} {Nortriptyline} {Protriptyline} {Trimipramine} {Iprindole} {Opipramol} Chemical structure of the tricyclic antidepressant amitriptyline Tricyclic antidepressants are a class of antidepressant drugs first used in the 1950s. ... Amitriptyline hydrochloride is an antidepressant drug from the tricyclic antidepressant group, which is sold under the trade names Elavil®, Tryptanol® or Endep®. It is a white, odorless, crystalline compound which is freely soluble in water. ... Clomipramine (brand-name Anafranil®) is a tricyclic antidepressant. ... dothiepin hydrochloride ... Doxepin is a tricyclic antidepressant, known under many brand-names such as Aponal®, the original preparation by Boehringer-Ingelheim, now part of the Roche group; Adapine®, Sinquan® and Sinequan® (Pfizer Inc. ... Imipramine (tradenames: Janimine®, Tofranil®) is an antidepressant medication belonging to a class called tricyclic antidepressants of the dibenzazepine group, mainly used in the treatment of clinical depression and enuresis. ... Nortriptyline is a tricyclic antidepressant marketed under the tradenames Aventyl® and Pamelor®. It is used to treat depression. ... Trimipramine is an tricyclic antidepressant with sedative and anxiolytic properties. ...


Tetracyclic antidepressants: {Maprotiline} {Mianserin} {Mirtazapine} {Amoxapine}{Trazodone}{Nefazodone} The structure of the tetracyclic antidepressant mirtazapine A tetracyclic antidepressant is an antidepressant drug from the tetracyclic drug group. ... To meet Wikipedias quality standards, this article may require cleanup. ... Mianserin is a tetracyclic antidepressant that has an antihistaminic and hypnosedative, but almost no anticholinergic effect. ... Mirtazapine is a prescription antidepressant introduced by Organon International in 1996. ... Amoxapine (Asendin®; Asendis®; Defanyl®; Demolox®; Moxadil®) is a tricyclic antidepressant of the dibenzoxazepine class. ... Trazodone (Desyrel®, Trittico®, Thombran®, Trialodine®) is a psychoactive compound with sedative, anxiolytic, and antidepressant properties. ... // Introduction Serzone (nefazodone) Serzone ( Nefazodone HCl ) is an antidepressant drug formerly marketed by Bristol-Myers Squibb. ...


  Results from FactBites:
 
desipramine - Depression symptoms, causes, and treatments including clinical and manic depression. (605 words)
Desipramine elevates mood and relieves depression by raising the levels of neurotransmitters in the brain.
Desipramine also is responsible for the antidepressant effects of another TCA, imipramine (TOFRANIL), since imipramine is converted by the body to desipramine.
Desipramine and other TCAs should not be used with monoamine oxidase inhibiting drugs, for example, isocarboxazid (Marplan), phenelzine (Nardil), tranylcypromine (Parnate), and procarbazine (Matulane) since high fever, convulsions and even death can occur when these drugs are used together.
ACS :: Cancer Drug Guide: desipramine hydrochloride (816 words)
Desipramine hydrochloride is used to reduce anxiety and depression and belongs to a general class of drugs called tricyclic antidepressants.
Desipramine hydrochloride works by increasing the amount of serotonin and norepinephrine in the brain so that the feeling of depression is prevented or relieved.
Since desipramine hydrochloride affects the central nervous system (CNS), it is important not to take other drugs or substances that are known CNS depressants such as alcohol, sedatives, and hypnotics.
  More results at FactBites »

 
 

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