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Encyclopedia > Deoxyguanosine

Guanosine is a molecule (known as a nucleoside) that is formed when guanine is attached to a ribose ring (also known as a ribofuranose) via a β-N9-glycosidic bond.


Guanosine can be phosphorylated to become GDP (guanosine diphosphate) and GTP (guanosine triphosphate) among other things.


If guanine is attached to a deoxyribose ring, it is known as a deoxyguanosine.


  Results from FactBites:
 
Arch Neurol -- Hepatocerebral Mitochondrial DNA Depletion Syndrome Caused by Deoxyguanosine Kinase (DGUOK) Mutations, ... (2558 words)
The deoxyguanosine kinase gene is mutated in individuals with depleted hepatocerebral mitochondrial DNA [letter].
A novel mutation in the deoxyguanosine kinase gene causing depletion of mitochondrial DNA.
Deoxyguanosine kinase mutations and combined deficiencies of the mitochondrial respiratory chain in patients with hepatic involvement.
Guanine nucleosides and Jurkat cell death: roles of ATP depletion and accumulation of deoxyribonucleotides -- Batiuk ... (4365 words)
Jurkat cells were incubated with 500 µM guanosine or deoxyguanosine for 8, 16, or 24 h.
Cells treated with guanosine or deoxyguanosine showed a mixture of necrotic features (yellow stain indicating inability to exclude propidium iodide due to damaged cell membrane, arrowheads) and apoptotic features (exclusion of propidium iodide and condensed and fragmented nuclei staining green with Hoechst 33343, arrows).
Effects of 8-aminoguanosine on the toxicity of guanosine and deoxyguanosine for malignant and normal lymphoid cells.
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