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Encyclopedia > Degradative enzyme
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CHEM – 527 Introductory Biochemistry (439 words)
Assuming that there was a primordial set of enzymes with dual substrate specificity that synthesized both glutamate and leucine, give at least two good reasons for the evolution of two separate sets of enzymes.
The biosynthetic enzyme is inhibited by isoleucine and the degradative enzyme is activated by AMP [J. Biol.
Enzyme bound indole is an intermediate in this reaction and the enzyme has two non-identical subunits.
Nucleotide Metabolism (3070 words)
Clinical manifestations of abnormal purine catabolism arise from the insolubility of the degradation byproduct, uric acid.
SCID is caused by a deficiency in the enzyme adenosine deaminase (
This is the enzyme responsible for converting adenosine to inosine in the catabolism of the purines.
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