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Encyclopedia > Corticotrope

Corticotropes are cells in the anterior pituitary which produce adrenocorticotrophic hormone.

Endocrine system - Pituitary gland edit (http://en.wikipedia.org/w/index.php?title=Template:Pituitary_gland&action=edit)
Posterior pituitary - Pars nervosa - Median emminence - Infundibular stalk
Anterior pituitary - Pars intermedia - Pars tuberalis - Pars distalis - Somatotropes - Lactotropes - Thyrotropes - Gonadotropes - Corticotropes

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Cushing Diease and Nelson Syndrome (4379 words)
The corticotropic pituitary adenomas responsible for the hypersecretion of ACTH are most often microadenomas averaging 5 mm in diameter.
Although it has been suggested that corticotropic adenomas have a predilection for the central mucoid core of the anterior lobe, they may be located anywhere in the sella.
Microscopically, corticotropic tumors are composed of compact sheets of uniform polygonal cells having round to oval nuclei with prominent nucleoli.
Classification of Pituitary Adenomas (8054 words)
In corticotropic cell adenomas associated with Cushing's disease, bundles of type 1 microfilaments are frequently observed in the cytoplasm, principally adjacent to the nucleus.
They are identical to Crooke's hyaline material noted in nontumorous corticotropic cells in patients treated with pharmacologic doses of cortisol or its derivatives, and in cases of the ectopic ACTH syndrome.
Hence corticotrope adenomas and gonadotrope adenomas, although they secrete more than one hormone, are not regarded as plurihormonal tumors and are not classified as such.
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