The Colton antigen system (Co) is present on the membranes of red blood cells and in the tubules of the kidney and helps determine a person's blood type. The Co antigen is found on a protein called aquaporin-1 which is responsible for water homeostasis and urine concentration. Human red blood cells Red blood cells are the most common type of blood cell and are the vertebrate bodys principal means of delivering oxygen to body tissues via the blood. ... Human kidneys viewed from behind with spine removed The kidneys are bean-shaped excretory organs in vertebrates. ... A total of 29 human blood group systems are recognized by the International Society of Blood Transfusion (ISBT). ... An antigen is a substance that stimulates an immune response, especially the production of antibodies. ... A representation of the 3D structure of myoglobin, showing coloured alpha helices. ... Sideview of Aquaporin 1 (AQP1) Channel Aquaporins are a class of integral membrane proteins that form pores in the membrane of biological cells and selectively conduct water molecules in and out, while preventing the passage of ions and other solutes. ... Homeostasis is the property of an open system, especially living organisms, to regulate its internal environment to maintain a stable, constant condition, by means of multiple dynamic equilibrium adjustments, controlled by interrelated regulation mechanisms. ...
The Co antigen is important in transfusion medicine. 99.8% of people possess the Co(a) allele. Individuals with Co(b) allele or who are missing the Colton antigen are at risk for a transfusion reaction such as hemolytic anemia or alloimmunization. Antibodies against the Colton antigen may also cause hemolytic disease of the newborn, in which a pregnant woman's body creates antibodies against the blood of her fetus, leading to destruction of the fetal blood cells. Transfusion medicine (or transfusiology) is the branch of medicine that is concerned with the transfusion of blood and blood components. ... An allele is any one of a number of viable DNA codings of the same gene (sometimes the term refers to a non-gene sequence) occupying a given locus (position) on a chromosome. ... Hemolytic anemia is anemia due to hemolysis, the abnormal breakdown of red blood cells either in the blood vessels (intravascular hemolysis) or elsewhere in the body (extravascular). ... Alloimmunity is a condition in which the body gains immunity against cells from another individual of the same species. ... Hemolytic disease of the newborn, (also known as HDN) is an alloimmune condition that develops in a fetus when IgG antibodies produced by the mother pass through the placenta and attack the fetuss red blood cells in the fetal circulation. ...
OMIM 110450 OMIM entry for the Colton antigen
^ Denker BM, Smith BL, Kuhajda FP, Agre P. Identification, purification, and partial characterization of a novel Mr 28,000 integral membrane protein from erythrocytes and renal tubules. J Biol Chem 1988;263:15634-15642. PMID 3049610
^ King LS, Choi M, Fernandez PC, Cartron JP, Agre P.Defective urinary-concentrating ability due to a complete deficiency of aquaporin-1. N Engl J Med. 2001 Jul 19;345(3):175-9. PMID 11463012
Categories: Transfusion medicine | Blood antigen systems Transfusion medicine (or transfusiology) is the branch of medicine that is concerned with the transfusion of blood and blood components. ... Blood transfusion is the taking of blood or blood-based products from one individual and inserting them into the circulatory system of another. ... In medicine, Cross-matching refers to the process of performing blood tests to determine the similarity between two different blood types. ... Schematic showing the direct Coombs test and the indirect Coombs test. ... This article is being considered for deletion in accordance with Wikipedias deletion policy. ... The International Society of Blood Transfusion (ISBT) is a scientific society, founded in 1935, which aims to promote the study of blood transfusion, and to spread the know-how about the manner in which blood transfusion medicine and science best can serve the patients interests. ... Plateletpheresis (also called thrombapheresis or thrombocytapheresis) is a special type of blood donation that only extracts platelets, the cells that cause blood clotting, from the blood. ... A total of 29 human blood group systems are recognized by the International Society of Blood Transfusion (ISBT). ... The ABO system is the most important blood type system in human blood transfusion. ... Discovery In 1950 the Duffy antigen was discovered in a multiply transfused hemophiliac in whose serum contained the first example of anti-Fya. ... Blood donation is a process by which a blood donor voluntarily has blood drawn for storage in a blood bank or for subsequent use in a blood transfusion. ... Human blood smear: a - erythrocytes; b - neutrophil; c - eosinophil; d - lymphocyte. ... Blood plasma is the liquid component of blood, in which the blood cells are suspended. ... A 250 ml bag of newly collected platelets. ... Cryoprecipitate is a blood product manufactured by warming frozen plasma. ... Plasmapheresis is the removal of (components of) blood plasma from the circulation. ... Human red blood cells Red blood cells are the most common type of blood cell and are the vertebrate bodys principal means of delivering oxygen from the lungs or gills to body tissues via the blood. ...
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