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Encyclopedia > Ciprofloxacin
Ciprofloxacin
Systematic (IUPAC) name
1-cyclopropyl-6-fluoro-4-oxo-
7-piperazin-1-yl-quinoline-3-carboxylic acid
Identifiers
CAS number 85721-33-1
ATC code J01MA02 S01AX13 S03AA07
PubChem 2764
DrugBank APRD00424
Chemical data
Formula C17H18FN3O3 
Mol. mass 331.346
Pharmacokinetic data
Bioavailability 69%[1]
Metabolism Hepatic, including CYP1A2
Half life 4 hours
Excretion Renal
Therapeutic considerations
Pregnancy cat.

B3(AU) C(US) Image File history File links This is a lossless scalable vector image. ... IUPAC nomenclature is a system of naming chemical compounds and of describing the science of chemistry in general. ... CAS registry numbers are unique numerical identifiers for chemical compounds, polymers, biological sequences, mixtures and alloys. ... The Anatomical Therapeutic Chemical Classification System is used for the classification of drugs. ... A section of the Anatomical Therapeutic Chemical Classification System. ... A section of the Anatomical Therapeutic Chemical Classification System. ... A section of the Anatomical Therapeutic Chemical Classification System. ... PubChem is a database of chemical molecules. ... The DrugBank database available at the University of Alberta is a unique bioinformatics and cheminformatics resource that combines detailed drug (i. ... This article or section does not cite any references or sources. ... General Name, symbol, number carbon, C, 6 Chemical series nonmetals Group, period, block 14, 2, p Appearance black (graphite) colorless (diamond) Standard atomic weight 12. ... General Name, Symbol, Number hydrogen, H, 1 Chemical series nonmetals Group, Period, Block 1, 1, s Appearance colorless Atomic mass 1. ... General Name, Symbol, Number fluorine, F, 9 Chemical series halogens Group, Period, Block 17, 2, p Appearance Yellowish brown gas Atomic mass 18. ... General Name, symbol, number nitrogen, N, 7 Chemical series nonmetals Group, period, block 15, 2, p Appearance colorless gas Standard atomic weight 14. ... General Name, Symbol, Number oxygen, O, 8 Chemical series nonmetals, chalcogens Group, Period, Block 16, 2, p Appearance colorless (gas) very pale blue (liquid) Standard atomic weight 15. ... The molecular mass (abbreviated Mr) of a substance, formerly also called molecular weight and abbreviated as MW, is the mass of one molecule of that substance, relative to the unified atomic mass unit u (equal to 1/12 the mass of one atom of carbon-12). ... In pharmacology, bioavailability is used to describe the fraction of an administered dose of unchanged drug that reaches the systemic circulation, one of the principal pharmacokinetic properties of drugs. ... Drug metabolism is the metabolism of drugs, their biochemical modification or degradation, usually through specialized enzymatic systems. ... This page is a candidate for speedy deletion. ... It has been suggested that Effective half-life be merged into this article or section. ... Excretion is the process of eliminating waste products of metabolism and other materials that are of no use. ... The pregnancy category of a pharmaceutical agent is an assessment of the risk of fetal injury due to the pharmaceutical, if it is used as directed by the mother during pregnancy. ... For other uses, see Australia (disambiguation). ... Motto: (Out Of Many, One) (traditional) In God We Trust (1956 to date) Anthem: The Star-Spangled Banner Capital Washington D.C. Largest city New York City None at federal level (English de facto) Government Federal constitutional republic  - President George Walker Bush (R)  - Vice President Dick Cheney (R) Independence from...

Legal status

Prescription Only (S4)(AU) POM(UK) The regulation of therapeutic goods, that is drugs and therapeutic devices, varies by jurisdiction. ... The Standard for the Uniform Scheduling of Drugs and Poisons, abbreviated SUSDP, is a document used in the regulation of drugs and poisons in Australia. ... For other uses, see Australia (disambiguation). ... A prescription drug is a licensed medicine that is regulated by legislation to require a prescription before it can be obtained. ...

Routes Oral, intravenous, topical (ear drops, eye drops)

Ciprofloxacin is the generic international name for the synthetic antibiotic manufactured and sold by Bayer Pharmaceutical under the brand names Cipro, Ciproxin and Ciprobay (and other brand names in other markets, e.g. veterinary drugs), belonging to a group called fluoroquinolones. Ciprofloxacin is bactericidal. Its mode of action depends upon blocking bacterial DNA replication by binding itself to an enzyme called DNA gyrase, thereby causing double-stranded breaks in the bacterial choromosome. In pharmacology and toxicology, a route of administration is the path by which a drug, fluid, poison or other substance is brought into contact with the body 1. ... In pharmacology and toxicology, a route of administration is the path by which a drug, fluid, poison or other substance is brought into contact with the body 1. ... Intravenous therapy or IV therapy is the giving of liquid substances directly into a vein. ... In medicine, a topical medication is applied to body surfaces such as the skin or mucous membranes such as the vagina, nasopharynx, or the eye. ... Ear drops are a form of medicine used to treat or prevent ear infections, especially infections of the outer ear and ear canal (Otitis externa). ... Eye drops are saline-containing drops used as a vector to administer medication in the eye. ... Staphylococcus aureus - Antibiotics test plate. ... Bayer may also refer to Bayer Leverkusen. ... Quinolones and fluoroquinolones form a group of broad-spectrum antibiotics. ... A bacteriocide or bactericide is a substance that kills bacteria and, preferably, nothing else. ... In pharmacology, the term mechanism of action refers to the specific biochemical interaction through which a drug substance produces its pharmacological effect. ... The structure of part of a DNA double helix Deoxyribonucleic acid, or DNA, is a nucleic acid molecule that contains the genetic instructions used in the development and functioning of all known living organisms. ... It has been suggested that DNA replicate, Replisome, Replication fork, Lagging strand, Leading strand be merged into this article or section. ... Ribbon diagram of the enzyme TIM, surrounded by the space-filling model of the protein. ... Topoisomerases (Type I: EC 5. ...

Contents

Activity

Ciprofloxacin is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria. It functions by inhibiting DNA gyrase, a type II topoisomerase, which is an enzyme necessary to separate replicated DNA, thereby inhibiting cell division. A broad-spectrum antibiotic is so called due to its activity against a wide range of infectious agents. ... Gram-positive bacteria are those that are stained dark blue or violet by gram staining, in contrast to gram-negative bacteria, which are not affected by the stain. ... Bacteria that are Gram-negative are not stained dark blue or violet by Gram staining, in contrast to Gram-positive bacteria. ... Topoisomerases (Type I: EC 5. ... Topoisomerase I solves the problem caused by tension generated by winding/unwinding of DNA. It wraps around DNA and makes a cut permitting the helix to spin. ...

Weak activity against: Genera see text The Enterobacteriaceae are a large family of bacteria, including many of the more familiar pathogens, such as Salmonella and Escherichia coli. ... Vibrio is a genus of bacteria, included in the gamma subgroup of the Proteobacteria. ... Binomial name Haemophilus influenzae (Lehmann & Neumann 1896) Winslow 1917 Haemophilus influenzae, formerly called Pfeiffers bacillus or Bacillus influenzae, is a non-motile Gram-negative coccobacillus first described in 1892 by Dr. Richard Pfeiffer during an influenza pandemic. ... Binomial name Haemophilus ducreyi A chancroid is an STD characterized by painful sores on the genitalia. ... Binomial name Neisseria gonorrhoeae Zopf, 1885 Neisseria gonorrhoeae is a species of Gram-negative bacteria responsible for the disease gonorrhoea. ... Binomial name Neisseria meningitidis Albrecht & Ghon, 1901 Neisseria meningitidis, also simply known as meningococcus is a gram-negative bacterium best known for its role in meningitis. ... Moraxella catarrhalis is a gram-negative, aerobic, oxidase-positive diplococcus. ... Species B. abortus B. melitensis Brucella is a genus of Gram-negative bacteria. ... Species C. fetus C. jejuni Campylobacter is a genus of Gram-negative bacteria. ... The introduction to this article provides insufficient context for those unfamiliar with the subject matter. ... Species Legionella adelaidensis Legionella anisa Legionella beliardensis Legionella birminghamensis Legionella bozemanii Legionella brunensis Legionella busanensis Legionella cherrii Legionella cincinnatiensis Legionella donaldsonii Legionella drancourtii Legionella drozanskii Legionella erythra Legionella fairfieldensis Legionella fallonii Legionella feeleii Legionella geestiana Legionella gratiana Legionella gresilensis Legionella hackeliae Legionella israelensis Legionella jamestowniensis Legionella jordanis Legionella lansingensis Legionella... Binomial name Pseudomonas aeruginosa (Schroeter 1872) Migula 1900 Synonyms Bacterium aeruginosum Schroeter 1872 Bacterium aeruginosum Cohn 1872 Micrococcus pyocyaneus Zopf 1884 Bacillus aeruginosus (Schroeter 1872) Trevisan 1885 Bacillus pyocyaneus (Zopf 1884) Flügge 1886 Pseudomonas pyocyanea (Zopf 1884) Migula 1895 Bacterium pyocyaneum (Zopf 1884) Lehmann and Neumann 1896 Pseudomonas polycolor... Binomial name Bacillus anthracis Cohn 1872 Bacillus anthracis is a Gram-positive, facultatively anaerobic, rod-shaped bacterium of the genus Bacillus. ... E. coli redirects here. ...

No activity against: Binomial name (Klein 1884) Chester 1901 Streptococcus pneumoniae, or pneumococcus, is a Gram-positive, alpha-hemolytic diplococcus bacterium and a member of the genus Streptococcus. ... Binomial name Chlamydia trachomatis Busacca, 1935 Chlamydia trachomatis is a species of the chlamydiae, a group of obligately intracellular bacteria. ... Binomial name Chlamydia pneumoniae Chlamydia pneumoniae is a obligate intracellular bacterium. ...

  • and others

The major adverse effect seen with use is gastrointestinal irritation, common with many antibiotics. Because of its general safety, potency and broad spectrum activity, ciprofloxacin was initially reserved as a drug of last resort for use on difficult and antibiotic-resistant infections. As with any antibiotic, however, increasing time and usage has led to an increase in ciprofloxacin-resistant infections, mainly in the hospital setting. Also implicated in the rise of resistant bacteria is the use of lower-cost, less potent fluoroquinolones, and the widespread addition of ciprofloxacin and other antibiotics to the feed of farm animals, which leads to greater and more rapid weight gain, for reasons which are not clear. Species etc. ... Burkholderia cepacia complex or simply Burkholderia cepacia is a group of catalase-producing, non-lactose-fermenting Gram-negative bacteria composed of at least seven different species, including Burkholderia multivorans, Burkholderia vietnamiensis, Burkholderia stabilis, and Burkholderia ambifaria. ... Enterococcus faecium is a gram positive bacterium in the genus Enterococcus. ... Binomial name Ureaplasma urealyticum Shepard et al. ... Binomial name Streptococcus pyogenes Rosenbach 1884 Streptococcus pyogenes is a Gram-positive coccus that grows in long chains depending on the culture method. ... In medicine, an Adverse effect is an abnormal, harmful, undesired and/or unintended side-effect, although not necessarily unexpected, which is obtained as a result of a therapy or other medical intervention, such as drug/chemotherapy, physical therapy, surgery, medical procedure, use of a medical device, etc. ... Upper and Lower gastrointestinal tract The gastrointestinal tract (GI tract), also called the digestive tract, or the alimentary canal, is the system of organs within multicellular animals that takes in food, digests it to extract energy and nutrients, and expels the remaining waste. ... An antibiotic is a drug that kills or slows the growth of bacteria. ... The term broad-spectrum antibiotic refers to an antibiotic with activity against a wide range of disease-causing bacteria. ... Drugs of last resort are drugs with the most potent antibiotic, antiviral, or anticancer effect, and for which no (or for cancer, very few) resistant strains are known. ... Antibiotic resistance is the ability of a micro-organism to withstand the effects of an antibiotic. ... Staphylococcus aureus - Antibiotics test plate. ... For the record label, see Hospital Records. ... Antibiotic resistance is the ability of a micro-organism to withstand the effects of an antibiotic. ... Quinolones and fluoroquinolones form a group of broad-spectrum antibiotics. ...


In cell culture it is used to treat infection with mycoplasma. Species M. genitalium M. hominis M. pneumoniae etc. ...


Label information

The drug is available for oral, parenteral and topical use. It is used in lower respiratory infections (pneumonias), urinary tract infections, STDs, septicemias, Legionellosis and atypical Mycobacterioses. Dosage in respiratory infections is 500-1500 mg a day in 2 doses. In pharmacology and toxicology, a route of administration is the path by which a drug, fluid, poison or other substance is brought into contact with the body 1. ... While often used as a synonym for pneumonia, the rubric of lower respiratory tract infection can also be applied to other types of infection including lung abscess, acute bronchitis, and empyema. ... This article is about human pneumonia. ... A urinary tract infection (UTI) is a bacterial infection that affects any part of the urinary tract. ... A sexually transmitted disease (STD) is an illness caused by an infectious pathogen that has a significant probability of transmission between humans by means of sexual contact, including vaginal intercourse, oral sex, and anal sex. ... Sepsis (in Greek Σήψις) is a serious medical condition caused by a severe systemic infection leading to a systemic inflammatory response. ... Legionellosis is an infection caused by the genus of Gram negative bacteria Legionella, notably Legionella pneumophila. ...


It is contraindicated in children, pregnancy, and in patients with epilepsy. Dose adjustment or avoidance may be necessary with liver or renal failure. A pregnant woman near the end of her term Pregnancy is the carrying of one or more offspring in an embryonal or fetal stage of development by female mammals, including humans, inside their bodies, between the stages of conception and birth. ... Liver failure is the final stage of liver disease. ... Renal failure is the condition in which the kidneys fail to function properly. ...


Ciprofloxacin can cause photosensitivity reactions and can elevate plasma theophylline levels to toxic values. It can also cause constipation and sensitivity to caffeine. Ciprofloxacin is also known to cause swelling of joints and cartilage, and cause tendon rupture and chronic pain. Photosensitivity is the amount to which an object reacts upon receiving photons of light. ... Theophylline is a methylxanthine drug used in therapy for respiratory diseases such as COPD or asthma under a variety of brand names. ... Constipation or irregularity, is a condition of the digestive system where a person (or animal) experiences hard feces that are difficult to egest; it may be extremely painful, and in severe cases (fecal impaction) lead to symptoms of bowel obstruction. ... Caffeine is a xanthine alkaloid compound that acts as a stimulant in humans. ...


Interactions

Quercetin, a flavonoid occasionally used as a dietary supplement may interact with fluoroquinolones, as quercetin competitively binds to bacterial DNA gyrase. Some foods such as garlic and apples contain high levels of quercetin. Whether this inhibits or enhances the effect of fluoroquinolones is not entirely clear.[2] Quercetin is a flavonoid that forms the backbone for many other flavonoids, including the citrus flavonoids rutin, hesperidin, naringin and tangeritin. ... Molecular structure of flavone The term flavonoid refers to a class of plant secondary metabolites based around a phenylbenzopyrone structure. ... A dietary supplement is intended to supply nutrients, (vitamins, minerals, fatty acids or amino acids) that are missing or not consumed in sufficient quantity in a persons diet. ...


Contraindications

Metal cations such as aluminium, magnesium, calcium, ferrous sulphate, and zinc are thought to form chelation complexes with fluoroquinolone antibiotics and prevent the drugs from being absorbed. Because of this, avoid taking ciprofloxacin with antacids which contain aluminium, magnesium or calcium. Sucralfate, which has a high aluminium content, also reduces the bioavailability of ciprofloxacin to approximately 4%.[3] Ciprofloxacin may be taken with meals or on an empty stomach. Ciprofloxacin should not be taken with dairy products or calcium-fortified juices alone, but may be taken with a meal that contains these products.[4] General Name, symbol, number aluminium, Al, 13 Chemical series poor metals Group, period, block 13, 3, p Appearance silvery Standard atomic weight 26. ... General Name, symbol, number magnesium, Mg, 12 Chemical series alkaline earth metals Group, period, block 2, 3, s Appearance silvery white solid at room temp Standard atomic weight 24. ... General Name, Symbol, Number calcium, Ca, 20 Chemical series alkaline earth metals Group, Period, Block 2, 4, s Appearance silvery white Standard atomic weight 40. ... Iron(II) sulfate (FeSO4) is an example of an ionic compound. ... General Name, Symbol, Number zinc, Zn, 30 Chemical series transition metals Group, Period, Block 12, 4, d Appearance bluish pale gray Standard atomic weight 65. ... A bottle of antacid tablets An antacid is any substance, generally a base, which counteracts stomach acidity. ... Sucralfate is a prescription medication used to treat peptic ulcers. ...


Heavy exercise is discouraged, as achilles tendon rupture has been reported in patients taking ciprofloxacin. Achilles tendon rupture due to ciprofloxacin use is typically associated with renal failure. Achilles tendon rupture commonly occurs as an acceleration injury e. ... Chronic renal failure (CRF, or chronic kidney failure, CKF, or chronic kidney disease, CKD) is a slowly progressive loss of renal function over a period of months or years and defined as an abnormally low glomerular filtration rate, which is usually determined indirectly by the creatinine level in blood serum. ...


The toxicity of drugs that are metabolised by the cytochrome P450 system is enhanced by concomitant use of some quinolones. They may also interact with the GABA A receptor and cause neurological symptoms; this is further augmented by certain non-steroidal anti-inflammatory drugs.[5] The GABAA receptor is one of the three ligand-gated ion channels responsible for mediating the effects of Gamma-AminoButyric Acid (GABA), the major inhibitory neurotransmitter in the brain. ... Non-steroidal anti-inflammatory drugs, usually abbreviated to NSAIDs, are drugs with analgesic, antipyretic and anti-inflammatory effects - they reduce pain, fever and inflammation. ...


Fluoroquinolones are increasingly contraindicated for patients who have been to S.E. Asia due to the growing prevalence of antibiotic resistance to the class of antibiotics in that region.[6]


Side Effects

In 2005 the FDA changed the package insert for Cipro [7] to acknowledge the tendon ruptures and the development of irreversable neurological conditions.


The incidence of side effects for ciprofloxacin is acceptable and relatively safe. Approximately 9% of patients taking the medication experience side effects ranging from mild to moderate, with the vast majority of those relating to metabolic-nutritional problems and the central nervous system.[8] Compared to other Fluoroquinolones the incidence and severity of side effects from ciprofloxacin is low.[9]


Dosing

Ciprofloxacin is available in oral tablets (250, 500, 750, and 1000 mg), as well as ready-made infusion bottles (200 and 400 mg). A combination preparation of ciprofloxacin 500 mg and tinidazole 600 mg is marketed under the name Ciplox-TZ® for infections where anaerobes or protozoa together with ciprofloxacin-sensitive aerobes are likely. Tinidazole is an anti-parasitic drug used against protozoan infections. ...


Due to its elimination half-life, ciprofloxacin is administered twice daily. No dose adjustments are generally required for mild to moderate renal impairment.

Cipro® brand ciprofloxacin 500mg tablets
Cipro® brand ciprofloxacin 500mg tablets

Image File history File links Metadata Size of this preview: 596 × 600 pixelsFull resolution (1200 × 1208 pixel, file size: 139 KB, MIME type: image/jpeg) File historyClick on a date/time to view the file as it appeared at that time. ... Image File history File links Metadata Size of this preview: 596 × 600 pixelsFull resolution (1200 × 1208 pixel, file size: 139 KB, MIME type: image/jpeg) File historyClick on a date/time to view the file as it appeared at that time. ...

Business aspects

The neutrality of this section is disputed.
Please see the discussion on the talk page.

The discovery and development of ciprofloxacin is that rare case of an actual groundbreaking new drug development, opening up an entire new class of antibiotics for further research, development, and marketing. Even more remarkable, it seems to be a case where the first drug discovered of this class remains the 'gold standard' in terms of efficacy, with the other drugs developed by other pharmaceutical companies relegated to 'me-too' status and forced to compete on the basis of lower cost. Image File history File links Unbalanced_scales. ... A pharmaceutical company is a licensed drug company, licensed to discover, develop, markets and distribute drugs. ...


Encouraged by the magnitude of this success, as well as the influx of cash, Bayer Pharmaceutical embarked on a plan to remake itself from a minor pharmaceutical manufacturer into a major player in the international pharmaceutical business, with a lock on the antibiotic field. Unfortunately, a combination of the tendency for antibiotics to be viewed as a commodity and prescribed on the basis of lowest cost, Bayer's inability to follow up with another 'blockbuster' discovery, and a general downturn in the international pharmaceutical business forced Bayer into a major downsizing in 2000-2001. Faced with the imminent expiry of its patent rights to ciprofloxacin in the early 2000s and the predictable loss of market share to generic ciprofloxacin, Bayer has resorted to the usual strategy of pharmaceutical companies in such a situation; focus on the development and patenting of new variations of the old drug (i.e. pediatric ciprofloxacin, intravenous ciprofloxacin, once-a-day ciprofloxacin, etc.), which will have the side effect of extending the patent on the original drug. Bayer may also refer to Bayer Leverkusen. ... Staphylococcus aureus - Antibiotics test plate. ... An antibiotic is a drug that kills or slows the growth of bacteria. ... Bayer AG (IPA pronunciation //) (ISIN: DE0005752000, NYSE: BAY, TYO: 4863 ) is a German chemical and pharmaceutical company founded in Barmen, Germany in 1863. ... Bayer AG (IPA pronunciation //) (ISIN: DE0005752000, NYSE: BAY, TYO: 4863 ) is a German chemical and pharmaceutical company founded in Barmen, Germany in 1863. ... A patent is a set of exclusive rights granted by a government to an inventor or applicant for a limited amount of time (normally maximum 20 years from the filing date, depending on extension). ... Bayer AG (IPA pronunciation //) (ISIN: DE0005752000, NYSE: BAY, TYO: 4863 ) is a German chemical and pharmaceutical company founded in Barmen, Germany in 1863. ... A pharmaceutical company is a licensed drug company, licensed to discover, develop, markets and distribute drugs. ...


"Cipro" became a household word during the 2001 anthrax attacks. (Redirected from 2001 anthrax attack) A letter sent to Senate Majority Leader Tom Daschle containing weaponised anthrax powder caused the deaths of two postal workers. ...


The panic reactions after 9/11 led to mass deployment and may well be the most signifigant factor in the decreased effectiveness of ciproflaxin by promoting the survival of resistant strains of bacteria.


Generic ciprofloxacin is now available in many markets around the world including the USA. In addition two new once daily formulations have been launched in the USA. Bayer have marketed Cipro XR® which is an extended release formulation. Meanwhile Depomed have developed ProQuin XR® another once daily formulation of ciprofloxacin which uses a gastric retention polymer technology to slow the release of ciprofloxacin into the blood.


Footnotes

  1. ^ Drusano GL, Standiford HC, Plaisance K, Forrest A, Leslie J, Caldwell J. Absolute oral bioavailability of ciprofloxacin. Antimicrob Agents Chemother 1986;30:444-6. PMID 3777908.
  2. ^ Hilliard JJ, Krause HM, Bernstein JI, Fernandez JA, Nguyen V, Ohemeng KA, Barrett JF. 'A comparison of active site binding of 4-quinolones and novel flavone gyrase inhibitors to DNA gyrase. Adv Exp Med Biol. 1995;390:59-69. PMID 8718602.
  3. ^ Spivey JM, Cummings DM, Pierson NR. Failure of prostatitis treatment secondary to probable ciprofloxacin-sucralfate drug interaction. Pharmacotherapy 1996;16:314-6. PMID 8820479.
  4. ^ Drug effects of Ciprofloxacin
  5. ^ Brouwers JR. Drug interactions with quinolone antibacterials. Drug Saf 1992;7:268-81. PMID 1524699.
  6. ^ Fluoroquinolone Resistance in Neisseria gonorrhoeae -- Colorado and Washington, 1995 [1]
  7. ^ Cipro package insert. Page 7 Warning of tendon ruptures and irreversable neurological conditions.
  8. ^ Schacht P. (1989). Safety of oral ciprofloxacin. An update based on clinical trial results. American Journal of Medcine: Nov 30;87(5A):98S-102S.
  9. ^ Rubinstein, E. (2001). History of Quinolones and Their Side Effects. Chemotherapy. 47:3-8 (DOI: 10.1159/000057838)

External links

  • Data sheet for Cipro
  • Fluoroquinolone Toxicity Research Foundation querying the overall safety of fluoroquinolones
  • Fluoroquinolone-Induced Tendinopathy: What do we know? Richard M. Harrell, MD.
  • Emergency Medicine Magzine a review of ciprofloxacin in relation to other fluoroquinolones
  • How Stuff Works - Cipro

  Results from FactBites:
 
Cipro (Ciprofloxacin Tablets / Oral Suspension) drug description - prescription drugs and medications at RxList (317 words)
CIPRO (ciprofloxacin hydrochloride) Tablets and CIPRO (ciprofloxacin*) Oral Suspension are synthetic broad spectrum antimicrobial agents for oral administration.
Ciprofloxacin hydrochloride, USP, a fluoroquinolone, is the monohydrochloride monohydrate salt of 1-cyclopropyl-6-fluoro-1, 4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid.
Ciprofloxacin Oral Suspension is a white to slightly yellowish suspension with strawberry flavor which may contain yellow-orange droplets.
MedlinePlus Drug Information: Ciprofloxacin (1725 words)
Ciprofloxacin is also used to treat or prevent anthrax in people who may have been exposed to anthrax germs in the air.
In the event of biological warfare, ciprofloxacin may be used to treat and prevent dangerous illnesses that are deliberately spread such as plague, tularemia, and anthrax of the skin or mouth.
Ciprofloxacin should not normally be given to children younger than 18 years old unless they have certain serious infections that cannot be treated with other antibiotics or they have been exposed to anthrax in the air.
  More results at FactBites »

 
 

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