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Encyclopedia > Chromosome 9 (human)

Chromosome 9 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 9 spans about 136 million base pairs (the building material of DNA) and represents between 4 and 4.5 percent of the total DNA in cells. Figure 1: Chromosome. ... Binomial name Homo sapiens Linnaeus, 1758 Subspecies Homo sapiens idaltu(extinct) Homo sapiens sapiens Homo (genus). ... In molecular biology, two nucleotides on opposite complementary DNA or RNA strands that are connected via hydrogen bonds are called a base pair (often abbreviated bp). ... Space-filling model of a section of DNA molecule Deoxyribonucleic acid (DNA) is a nucleic acid that contains the genetic instructions specifying the biological development of all cellular forms of life (and most viruses). ... Cells in culture, stained for keratin (red) and DNA (green) The cell is the structural and functional unit of all living organisms, and are sometimes called the building blocks of life. ...


Identifying genes on each chromosome is an active area of genetic research. Because researchers use different approaches to predict the number of genes on each chromosome, the estimated number of genes varies. Chromosome 9 likely contains between 800 and 1,200 genes. This stylistic schematic diagram shows a gene in relation to the double helix structure of DNA and to a chromosome (right). ...


Genes

The following are some of the genes located on chromosome 9:

  • ADAMTS13: ADAM metallopeptidase with thrombospondin type 1 motif, 13
  • ALAD: aminolevulinate, delta-, dehydratase
  • ALS4: amyotrophic lateral sclerosis 4
  • ASS: argininosuccinate synthetase
  • COL5A1: collagen, type V, alpha 1
  • ENG: endoglin (Osler-Rendu-Weber syndrome 1)
  • FXN: frataxin
  • GALT: galactose-1-phosphate uridylyltransferase
  • GRHPR: glyoxylate reductase/hydroxypyruvate reductase
  • IKBKAP: inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
  • TMC1: transmembrane channel-like 1
  • TSC1: tuberous sclerosis 1

ADAMTS13 (A Disintegrin And Metalloproteinase with a ThromboSpondin type 1 motif, member 13) is a zinc-containing metalloprotease enzyme that cleaves von Willebrand factor (vWf), a large protein involved in blood clotting. ... ASS or ass has several meanings: In zoology, an ass was the original word for donkey. ... #REDIRECT Electronic news gathering ... Galt is the name of some places in the United States of America: Galt, California Galt, Illinois Galt, Iowa Galt, Kansas Galt, Maryland Galt, Missouri Galt, Nevada The former city of Galt, Ontario, Canada, is now part of Cambridge. ...

Diseases

The following diseases are some of those related to genes on chromosome 9:

Motor Neurone Disease (MND) is a term used to cover a number of illnesses of the motor neurone. ... Citrullinemia s an inherited disorder that causes ammonia and other toxic substances to accumulate in the blood. ... Ehlers-Danlos syndrome is a group of rare (1 in 250,000 altogether) genetic disorders that diminish the bodys ability to make connective tissues. ... Familial dysautonomia, or FD, is a disorder of the autonomic nervous system resulting in variable syptoms including insensivity to pain, inability to produce tears, poor growth, and labile blood pressure. ... Friedreichs ataxia is rare, although it is one of the most common forms of autosomal recessive ataxia. ... Galactosemia is a rare genetic metabolic disorder which affects an individuals ability to properly digest the sugar galactose. ... In medicine, hereditary hemorrhagic telangiectasia (HHT), also known as Rendu-Osler-Weber syndrome, is a genetic disorder that leads to vascular malformations. ... Nonsyndromic deafness is hearing loss that is not associated with other signs and symptoms. ... This article is about the disease. ... Thrombotic thrombocytopenic purpura (TTP or Moschcowitz disease) is a rare disorder of the blood coagulation system that in most cases arises from the deficiency or inhibition of the enzyme responsible for cleaving von Willebrand factor. ... Tuberous sclerosis, (meaning hard potatoes), also known as Bourneville disease, is a rare genetic disorder primarily characterized by a triad of seizures, mental retardation, and skin lesions (called adenoma sebaceum). ...

References

  • Gilbert F, Kauff N (2001). Disease genes and chromosomes: disease maps of the human genome. Chromosome 9. Genet Test 5 (2): 157-74. PMID 11551106
  • Humphray SJ, Oliver K, Hunt AR, Plumb RW, Loveland JE, Howe KL, Andrews TD, Searle S, Hunt SE, Scott CE, Jones MC, Ainscough R, Almeida JP, Ambrose KD, Ashwell RI, Babbage AK, Babbage S, Bagguley CL, Bailey J, Banerjee R, Barker DJ, Barlow KF, Bates K, Beasley H, Beasley O, Bird CP, Bray-Allen S, Brown AJ, Brown JY, Burford D, Burrill W, Burton J, Carder C, Carter NP, Chapman JC, Chen Y, Clarke G, Clark SY, Clee CM, Clegg S, Collier RE, Corby N, Crosier M, Cummings AT, Davies J, Dhami P, Dunn M, Dutta I, Dyer LW, Earthrowl ME, Faulkner L, Fleming CJ, Frankish A, Frankland JA, French L, Fricker DG, Garner P, Garnett J, Ghori J, Gilbert JG, Glison C, Grafham DV, Gribble S, Griffiths C, Griffiths-Jones S, Grocock R, Guy J, Hall RE, Hammond S, Harley JL, Harrison ES, Hart EA, Heath PD, Henderson CD, Hopkins BL, Howard PJ, Howden PJ, Huckle E, Johnson C, Johnson D, Joy AA, Kay M, Keenan S, Kershaw JK, Kimberley AM, King A, Knights A, Laird GK, Langford C, Lawlor S, Leongamornlert DA, Leversha M, Lloyd C, Lloyd DM, Lovell J, Martin S, Mashreghi-Mohammadi M, Matthews L, McLaren S, McLay KE, McMurray A, Milne S, Nickerson T, Nisbett J, Nordsiek G, Pearce AV, Peck AI, Porter KM, Pandian R, Pelan S, Phillimore B, Povey S, Ramsey Y, Rand V, Scharfe M, Sehra HK, Shownkeen R, Sims SK, Skuce CD, Smith M, Steward CA, Swarbreck D, Sycamore N, Tester J, Thorpe A, Tracey A, Tromans A, Thomas DW, Wall M, Wallis JM, West AP, Whitehead SL, Willey DL, Williams SA, Wilming L, Wray PW, Young L, Ashurst JL, Coulson A, Blocker H, Durbin R, Sulston JE, Hubbard T, Jackson MJ, Bentley DR, Beck S, Rogers J, Dunham I (2004). DNA sequence and analysis of human chromosome 9. Nature 429 (6990): 369-74. PMID 15164053
Human chromosomes edit

{1} {2} {3} {4} {5} {6} {7} {8} {9} {10} {11} {12} {13} {14} {15} {16} {17} {18} {19} {20} {21} {22} {X} {Y} Figure 1: Chromosome. ... Chromosome 1 is one of the 23 pairs of chromosomes in humans. ... Chromosome 2 is one of the 23 pairs of chromosomes in humans. ... Chromosome 3 is one of the 23 pairs of chromosomes in humans. ... Chromosome 4 is one of the 23 pairs of chromosomes in humans. ... Chromosome 5 is one of the 23 pairs of chromosomes in humans. ... Chromosome 6 is one of the 23 pairs of chromosomes in humans. ... Chromosome 7 is one of the 23 pairs of chromosomes in humans. ... Chromosome 8 is one of the 23 pairs of chromosomes in humans. ... Chromosome 10 is one of the 23 pairs of chromosomes in humans. ... Chromosome 11 is one of the 23 pairs of chromosomes in humans. ... Chromosome 12 is one of the 23 pairs of chromosomes in humans. ... Chromosome 13 is one of the 23 pairs of chromosomes in humans. ... Chromosome 14 is one of the 23 pairs of chromosomes in humans. ... Chromosome 15 is one of the 23 pairs of chromosomes in humans. ... Chromosome 16 is one of the 23 pairs of chromosomes in humans. ... Chromosome 17 is one of the 23 pairs of chromosomes in humans. ... Chromosome 18 is one of the 23 pairs of chromosomes in humans. ... Chromosome 19 is one of the 23 pairs of chromosomes in humans. ... Chromosome 20 is one of the 23 pairs of chromosomes in humans. ... A common disease due to 3 of such chromosomes instead of the normal 2 is called Down syndrome. ... Chromosome 22 is one of the 23 pairs of chromosomes in humans. ... The human X chromosome, is is one of the two chromosomes involved in the XY sex-determination system. ... The human Y chromosome is one of two sex chromosomes, it contains the genes that cause testis development, thus determining maleness. ...


  Results from FactBites:
 
Human chromosomes 9 and 10 completed (500 words)
Chromosome 9 harbours four genes that can cause sex-reversal, all the human interferon type 1 genes (interferon is important in suppressing cancer development and in resisting virus infection), a gene implicated in neurodegenerative disease (CHAC), as well as a gene (abl) that is involved in 90 per cent of chronic myeloid leukaemia (CML) cases.
The two chromosome sequences point to the rich variety in our genome: chromosome 9 is peppered with regions copied from elsewhere in the genome; chromosome 10 is rich in overlapping genes.
On chromosome 9, genes such as IL11RA, a gene involved in the immune response, and C9orf37 (a gene identified using the newly available finished sequence) showed a significant difference at the sequence level.
  More results at FactBites »

 
 

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