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Encyclopedia > Chromosome 16 (human)

Chromosome 16 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 16 spans about 90 million base pairs (the building material of DNA) and represents just under 3 % of the total DNA in cells. Image File history File links Chromosome_16. ... Figure 1: Chromosome. ... Trinomial name Homo sapiens sapiens Linnaeus, 1758 Humans, or human beings, are bipedal primates belonging to the mammalian species Homo sapiens (Latin for wise man or knowing man) under the family Hominidae (known as the great apes). ... In molecular biology, two nucleotides on opposite complementary DNA or RNA strands that are connected via hydrogen bonds are called a base pair (often abbreviated bp). ... Cells in culture, stained for keratin (red) and DNA (green). ...


Identifying genes on each chromosome is an active area of genetic research. Because researchers use different approaches to predict the number of genes on each chromosome, the estimated number of genes varies. Chromosome 16 probably contains between 850 and 1,200 genes. This stylistic schematic diagram shows a gene in relation to the double helix structure of DNA and to a chromosome (right). ...


Genes

The following are some of the genes located on chromosome 16:

  • ABCC6: ATP-binding cassette, sub-family C (CFTR/MRP), member 6
  • CREBBP: CREB binding protein (Rubinstein-Taybi syndrome)
  • COQ7: ubiquitin biosynthesis
  • GAN: giant axonal neuropathy (gigaxonin)
  • LITAF: lipopolysaccharide-induced TNF factor
  • MEFV: Mediterranean fever
  • PKD1: polycystic kidney disease 1 (autosomal dominant)
  • TAT: tyrosine aminotransferase
  • TSC2: tuberous sclerosis 2

The protein encoded by the ABCC6 gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ... The clk-1 (Clock abnormal protein 1) gene encodes an enzyme (demethoxyubiquinone mono-oxygenase) that is necessary for ubiquinone biosynthesis in the worm C. elegans and other eukaryotes. ... Gan can have several meanings: A Romanization of the Chinese character 甘 (Gān), an abbreviation for Gansu Province in the Peoples Republic of China A Romanization of the Chinese character 赣 (Gàn), an abbreviation for: The Gan River Jiangxi Province in the Peoples Republic of China, through which... MEFV (Mediterranean fever) is a human gene that provides instructions for making a protein called pyrin (also known as marenostrin). ... Tat may refer to: The Tats, an Iranian ethnic group from the Caucasus. ...

Diseases

The following diseases are some of those related to genes on chromosome 16:

The foot of a person with Charcot-Marie-Tooth. ... To meet Wikipedias quality standards, this article may require cleanup. ... Familial Mediterranean fever (FMF) is a hereditary inflammatory disorder that affects groups of patients originating from around the Mediterranean Sea (hence its name). ... Giant axonal neuropathy is a rare inherited condition that causes disorganization of neurofilaments. ... Polycystic kidney disease (PKD) is a progressive, genetic disorder of the kidneys. ... Category: ... Rubinstein-Taybi syndrome (also known as Broad Thumb-Hallux syndrome) is a condition characterized by short stature, moderate to severe mental retardation, distinctive facial features, and broad thumbs and first toes. ... Tuberous sclerosis, (meaning hard potatoes), is a rare genetic disorder primarily characterized by a triad of seizures, mental retardation, and skin lesions (called adenoma sebaceum). ... Tyrosinemia (or Tyrosinaemia) is an error of metabolism, usually inborn, in which the body can not effectively break down the amino acid tyrosine, found in most animal and plant proteins. ...

References

  • Gilbert F (1999). "Disease genes and chromosomes: disease maps of the human genome. Chromosome 16". Genet Test 3 (2): 243-54. PMID 10464676.
  • Martin J, Han C, Gordon LA, Terry A, Prabhakar S, She X, Xie G, Hellsten U, Chan YM, Altherr M, Couronne O, Aerts A, Bajorek E, Black S, Blumer H, Branscomb E, Brown NC, Bruno WJ, Buckingham JM, Callen DF, Campbell CS, Campbell ML, Campbell EW, Caoile C, Challacombe JF, Chasteen LA, Chertkov O, Chi HC, Christensen M, Clark LM, Cohn JD, Denys M, Detter JC, Dickson M, Dimitrijevic-Bussod M, Escobar J, Fawcett JJ, Flowers D, Fotopulos D, Glavina T, Gomez M, Gonzales E, Goodstein D, Goodwin LA, Grady DL, Grigoriev I, Groza M, Hammon N, Hawkins T, Haydu L, Hildebrand CE, Huang W, Israni S, Jett J, Jewett PB, Kadner K, Kimball H, Kobayashi A, Krawczyk MC, Leyba T, Longmire JL, Lopez F, Lou Y, Lowry S, Ludeman T, Manohar CF, Mark GA, McMurray KL, Meincke LJ, Morgan J, Moyzis RK, Mundt MO, Munk AC, Nandkeshwar RD, Pitluck S, Pollard M, Predki P, Parson-Quintana B, Ramirez L, Rash S, Retterer J, Ricke DO, Robinson DL, Rodriguez A, Salamov A, Saunders EH, Scott D, Shough T, Stallings RL, Stalvey M, Sutherland RD, Tapia R, Tesmer JG, Thayer N, Thompson LS, Tice H, Torney DC, Tran-Gyamfi M, Tsai M, Ulanovsky LE, Ustaszewska A, Vo N, White PS, Williams AL, Wills PL, Wu JR, Wu K, Yang J, Dejong P, Bruce D, Doggett NA, Deaven L, Schmutz J, Grimwood J, Richardson P, Rokhsar DS, Eichler EE, Gilna P, Lucas SM, Myers RM, Rubin EM, Pennacchio LA (2004). "The sequence and analysis of duplication-rich human chromosome 16". Nature 432 (7020): 988-94. PMID 15616553.
Human chromosomes

{1} {2} {3} {4} {5} {6} {7} {8} {9} {10} {11} {12} {13} {14} {15} {16} {17} {18} {19} {20} {21} {22} {X} {Y} The human genome is the genome of Homo sapiens. ... Chromosome 1 is, by convention, the designation for the largest human chromosome. ... Chromosome 2 is one of the 23 pairs of chromosomes in humans. ... Chromosome 3 is one of the 23 pairs of chromosomes in humans. ... Chromosome 4 is one of the 23 pairs of chromosomes in humans. ... Chromosome 5 is one of the 23 pairs of chromosomes in humans. ... Chromosome 6 is one of the 23 pairs of chromosomes in humans. ... Chromosome 7 is one of the 23 pairs of chromosomes in humans. ... Chromosome 8 is one of the 23 pairs of chromosomes in humans. ... Chromosome 9 is one of the 23 pairs of chromosomes in humans. ... Chromosome 10 is one of the 23 pairs of chromosomes in humans. ... Chromosome 11 is one of the 23 pairs of chromosomes in humans. ... Chromosome 12 is one of the 23 pairs of chromosomes in humans. ... Chromosome 13 is one of the 23 pairs of chromosomes in humans. ... Chromosome 14 is one of the 23 pairs of chromosomes in humans. ... Chromosome 15 is one of the 23 pairs of chromosomes in humans. ... Chromosome 17 is one of the 23 pairs of chromosomes in humans. ... Chromosome 18 is one of the 23 pairs of chromosomes in humans. ... Chromosome 19 is one of the 23 pairs of chromosomes in humans. ... Chromosome 20 is one of the 23 pairs of chromosomes in humans. ... A common disease due to 3 of such chromosomes instead of the normal 2 is called Down syndrome. ... Chromosome 22 is one of the 23 pairs of chromosomes in humans. ... The X chromosome is one of the two sex chromosomes in mammals (the other is the Y chromosome). ... The human Y chromosome is one of two sex chromosomes, it contains the genes that cause testis development, thus determining maleness. ...


 
 

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