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Encyclopedia > Chromosome 11 (human)

Chromosome 11 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 11 spans about 134 million base pairs (the building material of DNA) and represents between 4 and 4.5 percent of the total DNA in cells. Figure 1: Chromosome. ... Trinomial name Homo sapiens sapiens Linnaeus, 1758 Humans, or human beings, are biologically classified as bipedal primates belonging to the mammalian species Homo sapiens (Latin for wise man or thinking man) under the family Hominidae (the great apes). ... Headline text this website sucks your mothers dickIn molecular biology, two nucleotides on opposite complementary DNA or RNA strands that are connected via hydrogen bonds are called a base pair (often abbreviated bp). ... The general structure of a section of DNA Deoxyribonucleic acid (DNA) is a nucleic acid —usually in the form of a double helix— that contains the genetic instructions specifying the biological development of all cellular forms of life, and most viruses. ... Cells in culture, stained for keratin (red) and DNA (green). ...


Identifying genes on each chromosome is an active area of genetic research. Because researchers use different approaches to predict the number of genes on each chromosome, the estimated number of genes varies. Chromosome 11 likely contains between 1,300 and 1,700 genes. This stylistic schematic diagram shows a gene in relation to the double helix structure of DNA and to a chromosome (right). ...


Genes

The following are some of the genes located on chromosome 11:

  • ACAT1: acetyl-Coenzyme A acetyltransferase 1 (acetoacetyl Coenzyme A thiolase)
  • ATM: ataxia telangiectasia mutated (includes complementation groups A, C and D)
  • CPT1A: carnitine palmitoyltransferase 1A (liver)
  • DHCR7: 7-dehydrocholesterol reductase
  • HBB: hemoglobin, beta
  • HMBS: hydroxymethylbilane synthase
  • HRAS: v-Ha-ras Harvey rat sarcoma viral oncogene homolog
  • KCNQ1: potassium voltage-gated channel, KQT-like subfamily, member 1
  • MEN1: multiple endocrine neoplasia I
  • MTMR2: myotubularin related protein 2
  • MYO7A: myosin VIIA
  • PTS: 6-pyruvoyltetrahydropterin synthase
  • SAA1: serum amyloid A1
  • SBF2: SET binding factor 2
  • SMPD1: sphingomyelin phosphodiesterase 1, acid lysosomal (acid sphingomyelinase)
  • TECTA: tectorin alpha
  • USH1C: Usher syndrome 1C (autosomal recessive, severe)

Ataxia-telangiectasia mutated kinase is a serine threonine kinase that is recruited and activated by double stranded breaks of DNA and the MRN complex. ... Her Majestys Bahamian (or Bermudan) Ship HMBS (gene) hydroxymethylbilane synthase gene, involved in heme biosynthesis Category: ... HRAS is a human gene that provides instructions for making a protein that is involved in cell division. ...

Diseases

The following diseases are some of those related to genes on chromosome 11:

The porphyrias are inherited or acquired disorders of certain enzymes in the heme biosynthetic pathway (also called porphyrin pathway). ... Ataxia-telangiectasia (AT) (Boder-Sedgwick syndrome or Louis-Bar syndrome) is a primary immunodeficiency disorder that occurs in an estimated incidence of 1 in 40,000 to 1 in 300,000 births (Lederman, 2000). ... Beta-ketothiolase deficiency is an uncommon inherited disorder in which the body cannot properly process the amino acid isolecine or the products of lipid breakdown. ... Thalassemia (American English) (or Thalassaemia in British English) is an inherited disease of the red blood cells, classified as a hemoglobinopathy. ... Cystoscopic view of a papillary bladder tumor (top); the bladder wall is visible on the bottom right Bladder cancer refers to any of several types of malignant growths of the urinary bladder. ... Breast cancer is cancer of breast tissue. ... Carnitine palmitoyltransferase I deficiency is a rare condition that prevents the body from converting certain fats called long-chain fatty acids into energy, particularly during periods without food. ... The foot of a person with Charcot-Marie-Tooth. ... Familial Mediterranean fever (FMF) is a hereditary inflammatory disorder that affects groups of patients originating from around the Mediterranean Sea (hence its name). ... Jervell and Lange-Nielsen syndrome is a condition that causes profound hearing loss and arrhythmia, it is a type of long QT syndrome. ... Multiple endocrine neoplasia type 1 is part of a group of disorders that affect the endocrine system. ... Niemann-Pick disease is an inherited condition involving lipid metabolism (the breakdown and use of fats and cholesterol in the body) in which harmful amounts of lipids accumulate in the spleen, liver, lungs, bone marrow, and brain. ... Nonsyndromic deafness is hearing loss that is not associated with other signs and symptoms. ... For the poem by Robert Browning see Porphyrias Lover. ... Romano-Ward syndrome, is the major variant of long QT syndrome. ... Sickle-shaped red blood cells Sickle cell anemia (American English), sickle cell anaemia (British English) or sickle cell disease is a genetic disease in which red blood cells may change shape under certain circumstances. ... Smith-Lemli-Opitz syndrome is a developmental disorder that affects many parts of the body. ... Tetrahydrobiopterin deficiency (also known as BH4 deficiency) is a rare disorder that increases the blood levels of a substance called phenylalanine. ... Usher syndrome is a genetic disease causing deaf-blindness. ...

References

  • Taylor TD, Noguchi H, Totoki Y, Toyoda A, Kuroki Y, Dewar K, Lloyd C, Itoh T, Takeda T, Kim DW, She X, Barlow KF, Bloom T, Bruford E, Chang JL, Cuomo CA, Eichler E, FitzGerald MG, Jaffe DB, LaButti K, Nicol R, Park HS, Seaman C, Sougnez C, Yang X, Zimmer AR, Zody MC, Birren BW, Nusbaum C, Fujiyama A, Hattori M, Rogers J, Lander ES, Sakaki Y (2006). "Human chromosome 11 DNA sequence and analysis including novel gene identification". Nature 440 (7083): 497-500. PMID 16554811.
  • Gilbert F (2000). "Disease genes and chromosomes: disease maps of the human genome". Genet Test 4 (4): 409-26. PMID 11216668.
Human chromosomes

{1} {2} {3} {4} {5} {6} {7} {8} {9} {10} {11} {12} {13} {14} {15} {16} {17} {18} {19} {20} {21} {22} {X} {Y} Figure 1: Chromosome. ... Chromosome 1 is one of the 23 pairs of chromosomes in humans. ... Chromosome 2 is one of the 23 pairs of chromosomes in humans. ... Chromosome 3 is one of the 23 pairs of chromosomes in humans. ... Chromosome 4 is one of the 23 pairs of chromosomes in humans. ... Chromosome 5 is one of the 23 pairs of chromosomes in humans. ... Chromosome 6 is one of the 23 pairs of chromosomes in humans. ... Chromosome 7 is one of the 23 pairs of chromosomes in humans. ... Chromosome 8 is one of the 23 pairs of chromosomes in humans. ... Chromosome 9 is one of the 23 pairs of chromosomes in humans. ... Chromosome 10 is one of the 23 pairs of chromosomes in humans. ... Chromosome 12 is one of the 23 pairs of chromosomes in humans. ... Chromosome 13 is one of the 23 pairs of chromosomes in humans. ... Chromosome 14 is one of the 23 pairs of chromosomes in humans. ... Chromosome 15 is one of the 23 pairs of chromosomes in humans. ... Chromosome 16 is one of the 23 pairs of chromosomes in humans. ... Chromosome 17 is one of the 23 pairs of chromosomes in humans. ... Chromosome 18 is one of the 23 pairs of chromosomes in humans. ... Chromosome 19 is one of the 23 pairs of chromosomes in humans. ... Chromosome 20 is one of the 23 pairs of chromosomes in humans. ... A common disease due to 3 of such chromosomes instead of the normal 2 is called Down syndrome. ... Chromosome 22 is one of the 23 pairs of chromosomes in humans. ... The X chromosome is one of the two sex chromosomes in mammals (the other is the Y chromosome). ... The human Y chromosome is one of two sex chromosomes, it contains the genes that cause testis development, thus determining maleness. ...


  Results from FactBites:
 
Chromosome 11 - Genetics Home Reference (389 words)
Chromosome 11 is one of the 23 pairs of chromosomes in humans.
Chromosome 11 spans about 134 million base pairs (the building material of DNA) and represents between 4 and 4.5 percent of the total DNA in cells.
Genes on chromosome 11 are among the estimated 20,000 to 25,000 total genes in the human genome.
  More results at FactBites »

 
 

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