Thus, specific blockers are known for cholinergic, muscarinic receptors innervated by postganglionic fibers of the parasympathetic division of the autonomic nervous system, for cholinergic, nicotinic receptors in both sympathetic and parasympathetic ganglia, and for cholinergic nicotinic receptors at the myoneural junction (motor end plates) of the somatic nervous system.
Cholinergic tone to the sphincter iridis muscle of the iris tends to contract the pupil.
The cholinergic innervation of the striatum is mostly intrinsic, arising from cholinergic interneurons.
The density of cholinergic innervation is very high in the striatum, high in the subthalamic nucleus and red nucleus, moderate in the globus pallidus and ventral tegmental area, and low in the pars compacta of the substantia nigra.
The majority of the cholinergic innervation for the globus pallidus, especially for its internal sector (which corresponds to the entopeduncular nucleus of nonprimates), however, appears to arise from cholinergic cells outside of the forebrain or from NGFr-negative neurons of the Ch1–Ch4 cell groups.
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