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Encyclopedia > Chinese Hamster Ovary cell

Chinese Hamster Ovary cells (CHO cells) are a cell line derived from Chinese Hamster ovary cells. They are often used in biological and medical research. They were introduced in the 1960s and are used in a cultured monolayer in culture flasks. They require the amino acid proline in their culture medium; this property makes them ideal for genetics research. CHO cells are used in studies of genetics, toxicity screening, nutrition and gene expression particularly expression of recombinant proteins. Epithelial cells in culture, stained for keratin (red) and DNA (green) Cell culture is the term applied when growing cells in a synthetic environment. ... Binomial name Cricetulus griseus Milne-Edwards, 1867 The Chinese Hamster is a species of hamster, scientific names Cricetulus griseus, which originates in the deserts of northern China and Mongolia. ... Human female internal reproductive anatomy Ovaries are egg-producing reproductive organs found in female organisms. ... Biology studies the variety of life (clockwise from top-left) E. coli, tree fern, gazelle, Goliath beetle Biology (from Greek Βìο meaning life and Λoγος meaning the study of) is the study of life. ... medicines, see medication and pharmacology. ... The 1960s decade refers to the years from January 1, 1960 to December 31, 1969, inclusive. ... A microbiological culture is a way to determine the cause of infectious disease by letting the agent multiply (reproduce) in predetermined media. ... Phenylalanine is one of the standard amino acids. ... L-Proline is one of the twenty proteinogenic units which are used in living organisms as the building blocks of proteins. ... For a non-technical introduction to the topic, please see Introduction to genetics. ... Recombinant proteins are proteins that are produced by different genetically modified organisms following insertion of the relevant DNA into their genome. ...


See also

Epithelial cells in culture, stained for keratin (red) and DNA (green) Cell culture is the term applied when cells are grown in a synthetic environment. ... It has been suggested that this article or section be merged into Pharmacology. ... Activities that need to be performed and results to be obtained a before a clinical trial in humans can begin. ... Caco-2 cell monolayer absorption model Cell-based functional assays, such as the Caco-2 drug transport model for assessing intestinal transport, are extremely valuable for screening lead compounds in drug discovery. ...

Reference

Tjio J. H., Puck T. T., Genetics of somatic mammalian cells. II. chromosomal constitution of cells intissue culture. J. Exp. Med. 1958; 108: 259-271.


External links


  Results from FactBites:
 
Nikon MicroscopyU: Phase Contrast Image Gallery - Chinese Hamster Ovary Cell Culture (239 words)
Commonly, hamsters are thought of as cute, furry, and disposable pets, but the small, rat-like, Chinese hamster serves a totally different function.
The Chinese hamster ovary (often abbreviated CHO) tissue is commonly cultured as individual cells in a monolayer and studied worldwide.
Chinese hamster ovary (CHO) cells were introduced in the early 1960s as a viable epithelial cell line containing twin female X chromosomes.
Chinese hamster - Wikipedia, the free encyclopedia (414 words)
The Chinese hamster is often kept as a pet or (in the past) as a laboratory animal.
Chinese hamsters are not related to the social "dwarf" hamsters.
In the past, Chinese hamsters were commonly used laboratory animals, until they were replaced by the common mouse and rat, which are easier to keep and breed.
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