Chinese Hamster Ovary cells (CHO cells) are a cell line derived from Chinese Hamsterovary cells. They are often used in biological and medical research. They were introduced in the 1960s and are used in a cultured monolayer in culture flasks. They require the amino acidproline in their culture medium; this property makes them ideal for genetics research. CHO cells are used in studies of genetics, toxicity screening, nutrition and gene expression particularly expression of recombinant proteins. Epithelial cells in culture, stained for keratin (red) and DNA (green) Cell culture is the term applied when growing cells in a synthetic environment. ... Binomial name Cricetulus griseus Milne-Edwards, 1867 The Chinese Hamster is a species of hamster, scientific names Cricetulus griseus, which originates in the deserts of northern China and Mongolia. ... Human female internal reproductive anatomy Ovaries are egg-producing reproductive organs found in female organisms. ... Biology studies the variety of life (clockwise from top-left) E. coli, tree fern, gazelle, Goliath beetle Biology (from Greek ÎÃ¬Î¿ meaning life and ÎoÎ³Î¿Ï meaning the study of) is the study of life. ... medicines, see medication and pharmacology. ... The 1960s decade refers to the years from January 1, 1960 to December 31, 1969, inclusive. ... A microbiological culture is a way to determine the cause of infectious disease by letting the agent multiply (reproduce) in predetermined media. ... Phenylalanine is one of the standard amino acids. ... L-Proline is one of the twenty proteinogenic units which are used in living organisms as the building blocks of proteins. ... For a non-technical introduction to the topic, please see Introduction to genetics. ... Recombinant proteins are proteins that are produced by different genetically modified organisms following insertion of the relevant DNA into their genome. ...
Epithelial cells in culture, stained for keratin (red) and DNA (green) Cell culture is the term applied when cells are grown in a synthetic environment. ... It has been suggested that this article or section be merged into Pharmacology. ... Activities that need to be performed and results to be obtained a before a clinical trial in humans can begin. ... Caco-2 cell monolayer absorption model Cell-based functional assays, such as the Caco-2 drug transport model for assessing intestinal transport, are extremely valuable for screening lead compounds in drug discovery. ...
Tjio J. H., Puck T. T., Genetics of somatic mammalian cells. II. chromosomal constitution of cells intissue culture. J. Exp. Med. 1958; 108: 259-271.
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