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Encyclopedia > Chemogenomics

Chemogenomics can be defined as a genomic response to chemical compounds. The goal is the rapid identification of novel drugs and drug targets embracing multiple early phase drug discovery technologies ranging from target identification and validation, over compound design and chemical synthesis to biological testing and ADME profiling. Genomics is the study of an organisms genome and the use of the genes. ... A chemical compound is a chemical substance formed from two or more elements, with a fixed ratio determining the composition. ... Oral medication Caffeine is the most widely used psychoactive substance in the world. ... It has been suggested that this article or section be merged into Pharmacology. ... In chemistry, the phrase chemical synthesis appears to have one of two meanings. ... ADME is an acronym for Absorption, Distribution, Metabolization, and Excretion, and describes the effectiveness of a pharmaceutical compound within an organism. ...


See also

Genomics is the study of an organisms genome and the use of the genes. ... Structural genomics or structural bioinformatics refers to the analysis of macromolecular structure particularly proteins. ... The terms pharmacogenomics and pharmacogenetics tend to be used interchangeably, and a precise, consensus definition of either remains elusive. ... Pharmacogenomics is the branch of pharmaceutics which deals with the influence of genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with a drugs efficacy or toxicity. ... Toxicogenomics is a form of analysis by which the activity of a particular toxin or chemical substance on living tissue can be identified based upon a profiling of its known effects on genetic material. ... Making sense of the huge amounts of DNA data (pictured) produced by gene sequencing projects is just one of the tasks faced by bioinformatics. ... Cheminformatics is the use of computer and informational techniques, applied to a range of problems in the field of chemistry. ... Computational chemistry is a branch of chemistry that uses the results of theoretical chemistry incorporated into efficient computer programs to calculate the structures and properties of molecules and solids, applying these programs to real chemical problems. ... The factual accuracy of this article is disputed. ... QSAR (Quantitative Structure-Activity Relationship, sometimes the A stands also for Affinity=reactivity) is the quantitative correlation of the biological (ecological, toxicological or pharmacological) activity to the structure of chemical compounds, which allows the prediction of the so-called drug efficacy of a structurally related compound. ...

References

  • Chemogenomics in Drug Discovery: A Medicinal Chemistry Perspective, H. Kubinyi (Editor), G. Müller (Editor), R. Mannhold (Series Editor), G. Folkers (Series Editor), Wiley-VCH, 2004.ISBN 3-527-30987-X

External links

  • Kubinyi's slides
  • Nature chemical genomics gateway
Genomics topics
Genome project | Glycomics | Human Genome Project | Proteomics
Chemogenomics | Structural genomics | Pharmacogenetics | Pharmacogenomics | Toxicogenomics
Bioinformatics | Cheminformatics | Systems biology

 
 

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