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Encyclopedia > Cell mediated immunity

Cell-mediated immunity is an immune response that does not involve antibodies but rather involves the activation of macrophages and NK-cells, the production of antigen-specific cytotoxic T-lymphocytes, and the release of various cytokines in response to an antigen. Cellular immunity protects the body by:

  1. activating antigen-specific cytotoxic T-lymphocytes that are able to lyse body cells displaying epitopes of foreign antigen on their surface, such as virus-infected cells, cells with intracellular bacteria, and cancer cells displaying tumor antigens;
  2. activating macrophages and NK cells, enabling them to destroy intracellular pathogens; and
  3. stimulating cells to secrete a variety of cytokines that influence the function of other cells involved in adaptive immune responses and innate immune responses.

Cell-mediated immunity is directed primarily microbes that survive in phagocytes and microbes that infect non-phagocytic cells. It is most effective in removing virus-infected cells, but also participates in defending against fungi, protozoans, cancers and intracellular bacteria. It also plays a major role in transplant rejection.



Immune system
Humoral immune system - Cellular immune system - Lymphatic system
White blood cells - B cells - Antibodies - Antigen (MHC)
Lymphocytes: T cells (Cytotoxic & Helper) - B cells (Plasma cells & Memory B cells)



  Results from FactBites:
 
Cell-mediated immunity - Wikipedia, the free encyclopedia (231 words)
Humoral immunity, for which the protective function of immunization could be found in the humor (cell-free bodily fluid or serum), 2.
Cellular immunity, for which the protective function of immunization was associated with cells.
Cell-mediated immunity is directed primarily at microbes that survive in phagocytes and microbes that infect non-phagocytic cells.
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