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Encyclopedia > Carfentanil

Carfentanil chemical structure
Carfentanil Image File history File links Carfentanil molecule. ...

4((1-oxopropyl)phenylamino)-1-
(2-phenylethyl)-4-piperidinecarboxylic acid, methyl ester
CAS number
59708-52-0
ATC code
N/A
Chemical formula C24H30N2O3
Molecular weight 394.512
Bioavailability  ?
Metabolism  ?
Elimination half-life  ?
Excretion  ?
Pregnancy category  ?
Legal status Schedule II (USA)
Routes of administration  ?

Carfentanil, also Carfentanyl, is an analogue of the popular opioid Fentanyl, and is currently the most potent opioid known [Actually Ohmefentanil is 13,000X morphine]. It has a quantitative potency approximately 10,000 times that of morphine and 100 times that of fentanyl (activity in humans starting at about 1 µg). It is marketed under the trade name Wildnil as a tranquilizer for large animals. Carfentanyl is intended for animal use only as its extreme potency makes it inappropriate for use in humans [Actually its short duration is primarily the reason for this]. CAS registry numbers are unique numerical identifiers for chemical compounds, polymers, biological sequences and alloys. ... The Anatomical Therapeutic Chemical Classification System is used for the classification of drugs. ... A chemical formula (also called molecular formula) is a concise way of expressing information about the atoms that constitute a particular chemical compound. ... The molecular mass of a substance (less accurately called molecular weight and abbreviated as MW) is the mass of one molecule of that substance, relative to the unified atomic mass unit u (equal to 1/12 the mass of one atom of carbon-12). ... In pharmacology, bioavailability is used to describe the fraction of an administered dose of medication that reaches the systemic circulation, one of the principal pharmacokinetic properties of drugs. ... The elimination half-life of a drug (or any xenobiotic agent) refers to the timecourse necessary for the quantity of the xenobiotic agent in the body (or plasma concentration) to be reduced to half of its original level through various elimination processes. ... Excretion is the biological process by which an organism chemically separates waste products from its body. ... The pregnancy category of a pharmaceutical agent is an assessment of the risk of fetal injury due to the pharmaceutical, if it is used as directed by the mother. ... The regulation of therapeutic goods, that is drugs and therapeutic devices, varies by jurisdiction. ... An opioid is any agent that binds to opioid receptors found principally in the central nervous system and gastrointestinal tract. ... Fentanyl is an opioid analgesic, first synthesized in Belgium in the late 1950s, with an analgesic potency of about 80 times that of morphine. ... Morphine (INN), the principal active agent in opium, is a powerful opioid analgesic drug. ... The microgram (symbol µg, sometimes mcg) is an SI unit of mass. ... A sedative is a drug that depresses the central nervous system (CNS), which causes calmness, relaxation, reduction of anxiety, sleepiness, slowed breathing, slurred speech, staggering gait, poor judgment, and slow, uncertain reflexes. ...


It is thought (Wax et al 2003) that in the 2002 Moscow theater hostage crisis, Russian military made use of an aerositalized form of carfentanil to subdue Chechen hostage takers [where is your evidence that it was not another fentanyl derivative?]. Its short action, easy reversability and therapeutic index (10600 vs. 300 for fentanyl) would make it a near-perfect agent for this purpose. Wax et al surmise from the evidence available that the Moscow emergency services had not been informed of the use of the agent, and therefore did not have adequate supplies of naloxone or naltrexone (opiate antagonists) to prevent complications in many of the victims. Assuming that carfentanil was the only active constituent (which has not been verified by the Russian military), the primary acute toxic effect to the theatre victims would have been opioid-induced apnea; in this case mechanical ventilation and/or treatment with opioid antagonists would have been life-saving for many or all victims. 2002 (MMII) is a common year starting on Tuesday of the Gregorian calendar. ... The Moscow theater hostage crisis was the October 23, 2002 seizure of a crowded Moscow theatre by Chechen rebels, who took over 700 hostages and demanded the withdrawal of Russian forces from Chechnya. ... The therapeutic index of a medication is a comparison of the amount that causes the therapeutic effect to the amount that causes toxic effects. ... Fentanyl is an opioid analgesic, first synthesized in Belgium in the late 1950s, with an analgesic potency of about 80 times that of morphine. ... Naloxone is a drug used to counter the effects of overdosing on opioids such as heroin and morphine. ... Naltrexone is an opioid receptor antagonist used primarily in the management of alcohol dependence and opioid dependence. ... Apnea (British spelling - apnoea) is the absence of external breathing. ... ventilation balloon In medicine, mechanical ventilation is a method to assist or replace spontaneous breathing. ...


Reference

  • Wax PM, Becker CE, Curry SC. Unexpected "gas" casualties in Moscow: a medical toxicology perspective. Ann Emerg Med 2003;41:700-5. PMID 12712038.


Analgesics edit

{Paracetamol (acetaminophen)} {NSAIDs} {Opiates} {Tetrahydrocannabinol} {Ketamine} An analgesic (colloquially known as painkiller) is any member of the diverse group of drugs used to relieve pain and to achieve analgesia. ... Paracetamol (INN) or acetaminophen (USAN) is a popular analgesic and antipyretic drug that is used for the relief of fever, headaches, and other minor aches and pains. ... Wikipedia does not yet have an article with this exact name. ... An opioid is any agent that binds to opioid receptors found principally in the central nervous system and gastrointestinal tract. ... Tetrahydrocannabinol, also known as THC, Δ9-THC, Δ9-tetrahydrocannabinol (delta-9-tetrahydrocannabinol), Δ1-tetrahydrocannabinol (using an older numbering scheme), or dronabinol. ... Ketamine is a general dissociative anaesthetic for human and veterinary use. ...

NSAIDs edit

{Acetaminophen} {Aspirin} {Celecoxib} {Diclofenac} {Ibuprofen} {Ketoprofen} {Ketorolac} {Meloxicam} {Naproxen} {Rofecoxib} {Indomethacin} Non-steroidal anti-inflammatory drugs, usually abbreviated to NSAIDs, are drugs with analgesic, antipyretic and anti-inflammatory effects - they reduce pain, fever and inflammation. ... Acetaminophen (USAN) or paracetamol (INN), is a popular analgesic and antipyretic drug that is used for the relief of fever, headaches, and other minor aches and pains. ... Aspirin or acetylsalicylic acid is a drug in the family of salicylates, often used as an analgesic (against minor pains and aches), antipyretic (against fever), and anti-inflammatory. ... Celecoxib is a non-steroidal anti-inflammatory drug (NSAID) used in the treatment of osteoarthritis, rheumatoid arthritis, acute pain, painful menstruation and menstrual symptoms, and to reduce numbers of colon and rectum growths polyps in patients with familial adenomatous polyposis. ... Diclofenac (marketed as Voltaren®, Voltarol® and Cataflam®) is a non-steroidal anti-inflammatory drug (NSAID) taken to reduce inflammation, such as in arthritis or acute injury. ... Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) widely marketed under various trademarks including Act-3, Advil, Brufen, Motrin, Nuprin, and Nurofen; a standing joke about some athletes regular use has produced Vitamin I as a slang term for it. ... Ketoprofen, 2-(3-benzoylphenyl)-propionic acid (chemical formula C12H12O2) is one of the propionic acid class of non-steroidal anti-inflammatory drug (NSAID) with additional analgesic and anti-pyretic effects. ... Ketorolac or ketorolac tromethamine (marketed as Toradol® - generics have been approved) is a non-steroidal anti-inflammatory drug (NSAID) in the family of propionic acids, often used as an analgesic, antipyretic (fever reducer), and anti-inflammatory. ... Meloxicam is a nonsteroidal anti-inflammatory drug used to relieve the symptoms of arthritis, primary dysmenorrhoea, pyrexia; and as an analgesic, especially where there is an inflammatory component. ... Naproxen (trade names: Aleve, Anaprox, Naprosyn, Naprelan) is a non-steroidal anti-inflammatory drug (NSAID) commonly used for the reduction of mild to moderate pain, fever, inflammation and stiffness caused by conditions such as osteoarthritis, rheumatoid arthritis, psoriatic arthritis, gout, ankylosing spondylitis, injury, menstrual cramps, tendinitis, bursitis, and the treatment... Rofecoxib is a nonsteroidal anti-inflammatory drug (NSAID) that was used in the treatment of osteoarthritis, acute pain conditions, and dysmenorrhoea. ... Indomethacin (also indometacin) is a non-steroidal anti-inflammatory drug commonly used to reduce fever, pain, stiffness, and swelling. ...

Opioids edit

{Alfentanil} {Buprenorphine} {Carfentanil} {Codeine} {Codeinone} {Dextropropoxyphene} {Dihydrocodeine} {Fentanyl} {Heroin} {Hydrocodone} {Hydromorphone} {Methadone} {Morphine} {Morphinone} {Oxycodone} {Oxymorphone} {Pethidine (Meperidine)} {Remifentanil} {Sufentanil} {Tramadol} An opioid is any agent that binds to opioid receptors found principally in the central nervous system and gastrointestinal tract. ... Alfentanil (Alfenta) is a parenteral short-acting opioid painkiller, used for anaesthesia in surgery. ... Buprenorphine, also colloquially referred to as bupe, is an opioid drug with partial agonist and antagonist actions. ... Codeine (INN) is an opioid used for its analgesic, antitussive and antidiarrheal properties. ... Codeinone is a strong Opiod. ... Dextropropoxyphene is an analgesic in the opioid category. ... penis ... Fentanyl is an opioid analgesic, first synthesized in Belgium in the late 1950s, with an analgesic potency of about 80 times that of morphine. ... Heroin or diacetylmorphine (INN) is an alkaloid opioid. ... Hydrocodone or dihydrocodeinone (marketed as Vicodin, Anexsia, Dicodid, Hycodan, Hycomine, Lorcet, Lortab, Norco, Tussionex, Vicoprofen) is an opioid derived from either of the naturally occurring opiates - codeine or thebaine. ... // Overview Hydromorphone is a drug used to relieve moderate to severe pain. ... Methadone is a synthetic opioid analgesic synthesized in 1937 by German scientists Max Bockmühl and Gustav Ehrhart at IG Farben (Hoechst-Am-Main) who were searching for an analgesic that would be easier to use during surgery and also have low addiction potential. ... Morphine (INN), the principal active agent in opium, is a powerful opioid analgesic drug. ... Morphinone is a very strong Opiod. ... Oxycodone is a very powerful and potentially addictive opioid analgesic medication synthesized from thebaine. ... Oxymorphone is a powerful synthetic narcotic analgesic drug that is similar to morphine. ... Pethidine (INN) or meperidine (USAN) (also referred to as: isonipecaine; lidol; operidine; pethanol; piridosal; Algil®; Alodan®; Centralgin®; Demerol®; Dispadol®; Dolantin®; Dolestine®; Dolosal®; Dolsin®; Mefedina®) is a fast-acting opioid analgesic drug. ... Some factual claims in this article or section need to be verified. ... Sufentanil is a drug that belongs to the class of drugs known as the opioid analgesic drugs. ... Tramadol is an opioid used as an analgesic for treating moderate to severe pain. ...


  Results from FactBites:
 
Carfentanil - Drug information from Medic8.com (353 words)
Carfentanil or Carfentanyl is an analogue of the popular synthetic opioid analgesic fentanyl, and is one of the most potent opioids known (also the most potent opioid used commercially).
Carfentanil is intended for animal use only as its extreme potency makes it inappropriate for use in humans.
Assuming that carfentanil was the only active constituent (which has not been verified by the Russian military), the primary acute toxic effect to the theatre victims would have been opioid-induced apnoea; in this case mechanical ventilation and/or treatment with opioid antagonists would have been life-saving for many or all victims.
Carfentanil - Wikipedia, the free encyclopedia (345 words)
Carfentanil or Carfentanyl (R33799) is an analogue of the popular synthetic opioid analgesic fentanyl, and is one of the most potent opioids known (also the most potent opioid used commercially).
It is thought that in the 2002 Moscow theater hostage crisis, the Russian military made use of an aerosol form of carfentanil to subdue Chechen hostage takers.
Assuming that carfentanil was the only active constituent (which has not been verified by the Russian military), the primary acute toxic effect to the theatre victims would have been opioid-induced apnea; in this case mechanical ventilation and/or treatment with opioid antagonists would have been life-saving for many or all victims.
  More results at FactBites »

 
 

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