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Encyclopedia > Carbimazole
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Carbimazole is used to treat hyperthyroidism. It prevents the peroxidase enzyme from coupling and iodinating the tyrosine residues on thyroglobulin, hence reducing the T3/T4.

See propylthiouracil Propylthiouracil is a a drug used to treat hyperthyroidism. ...

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Carbimazole and the Thioamide/Thioureylene family (709 words)
The antithyroidal drugs Carbimazole, Methimazole and Propylthiouracil all contain a thioamide group which is essential for antithyroid action.
Carbimazole, which is converted to Methimazole in the body is widely used in the UK.
Carbimazole is rapidly converted to Methimazole, which is pharmacologically active.
Graves’ Disease (1250 words)
Start carbimazole 20 mg twice a day, and arrange for the free T4 and TSH to be measured 4 to 6 weeks later.
I don’t believe it is worthwhile persevering with carbimazole for a year in these cases, and once the patient is euthyroid I recommend surgery or radioactive iodine.
Carbimazole has been associated with a aplasia cutis, but titrated dose carbimazole is safe during pregnancy.
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