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Encyclopedia > Cancer procoagulant

Cancer procoagulant is a hypothesised protein, most likely a cysteine protease enzyme (EC 3.4.22.26 (http://www.expasy.org/cgi-bin/nicezyme.pl?3.4.22.26)), that occurs only in fetal and malignant cells. Its activity appears to be the activation of factor X, one of the coagulation factors, and would account for the increased incidence of thrombosis in cancer patients. Tissue factor (TF) is also known to be present at increased levels around malignant cells. A representation of the 3D structure of myoglobin, showing coloured alpha helices. ... Neuraminidase ribbon diagram An enzyme (in Greek en = in and zyme = leaven) is a protein, or protein complex, that catalyzes a chemical reaction and also controls the 3D orientation of the catalyzed substrates. ... EC numbers (Enzyme Commission numbers) are a numerical classification scheme for enzymes, based on the chemical reactions they catalyze. ... Fetus at eight weeks A fetus (alternatively foetus or fœtus) is an embryo in later stages of development, from the third month of pregnancy until birth in humans. ... When normal cells are damaged or old they undergo apoptosis; cancer cells, however, avoid apoptosis. ... Factor X, also known by the eponym Stuart-Prower factor or as thrombokinase, is an enzyme ( EC 3. ... The coagulation of blood is a complex process during which blood forms solid clots. ... Thrombosis is the formation of a clot or thrombus inside a blood vessel, obstructing the flow of blood through the circulatory system. ...


Reference

  • De Cicco M. The prothrombotic state in cancer: pathogenic mechanisms. Crit Rev Oncol Hematol 2004;50:187-96. PMID 15182825.

  Results from FactBites:
 
Cancer procoagulant in acute non lymphoid leukemia: relationship of enzyme detection to disease activity. (220 words)
Cancer procoagulant in acute non lymphoid leukemia: relationship of enzyme detection to disease activity.
Cancer procoagulant in acute non lymphoid leukemia: relationship of enzyme detection to disease activity.Blast cell extracts from patients with acute non lymphoid leukemia (ANLL) express cancer procoagulant (CP).
The procoagulant activity in either the presence or absence of F VII and sensitivity to cysteine proteinase inhibitors were tested on cell extracts.
Cancer and the prothrombotic state - Gregory YH Lip, Bernard SP Chin , and Andrew D Blann (5408 words)
The many signs and symptoms of the prothrombotic state in cancer range from asymptomatic basic abnormal coagulation tests to massive clinical thromboembolism, when the patient may be gravely ill. Many procoagulant factors, such as tissue factor and cancer procoagulant, are secreted by or are expressed at the cell surface of many tumours.
Some cancers are more likely to be prothrombotic than others, but this feature is also influenced by disease staging, immobility, and being in hospital, as well as by interventions such as chemotherapy or surgery.
Cancer procoagulant is a cysteine proteinase growth factor, consisting of a calcium-dependent, manganese stimulated enzyme.
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