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Encyclopedia > Calbindin
calbindin 1, 28kDa
Identifiers
Symbol(s) CALB1 CALB
Entrez 793
OMIM 114050
RefSeq NM_004929
UniProt P05937
Other data
Locus Chr. 8 p11
calbindin 2, 29kDa (calretinin)
Identifiers
Symbol(s) CALB2
Entrez 794
OMIM 114051
RefSeq NM_001740
UniProt P22676
Other data
Locus Chr. 16 q22.1

Calbindin describes calcium binding proteins first described as the vitamin D-dependent calcium binding proteins in intestine and kidney. Calbindin-D9k is present in mammalian intestinal epithelial cells (enterocytes) and mediates the transport of calcium across the enterocytes from the apical side, where entry is regulated by the calcium channel TRPV6, to the basolateral side, where calcium pumps such as PMCA1 utilize intracellular ATP to pump calcium into the blood. Calbindin-D28k performs as similar role in the intestine in birds and in the mammalian kidney; it is also found in a number of other neuroendocrine cells, particularly in the cerebellum. Calbindin-D9k can also be found in the kidney and uterus in some mammalian species. Apart from their calcium binding domains, EF-hands, of which calbindin-D9k has two, and calbindin-D28k four, there is no homology between these proteins. Hugo is a masculine name. ... The Entrez Global Query Cross-Database Search System allows access to databases at the National Center for Biotechnology Information (NCBI) website. ... The Mendelian Inheritance in Man project is a database that catalogues all the known diseases with a genetic component, and - when possible - links them to the relevant genes in the human genome. ... The National Center for Biotechnology Information (NCBI) is part of the US National Library of Medicine (NLM), which is a branch of the US National Institutes of Health. ... Swiss-Prot is a curated biological database of protein sequences created in 1986 by Amos Bairoch during his PhD and developed by the Swiss Institute of Bioinformatics and the European Bioinformatics Institute. ... In biology and evolutionary computation, a locus is the position of a gene (or other significant sequence) on a chromosome. ... Chromosome 8 is one of the 23 pairs of chromosomes in humans. ... Hugo is a masculine name. ... The Entrez Global Query Cross-Database Search System allows access to databases at the National Center for Biotechnology Information (NCBI) website. ... The Mendelian Inheritance in Man project is a database that catalogues all the known diseases with a genetic component, and - when possible - links them to the relevant genes in the human genome. ... The National Center for Biotechnology Information (NCBI) is part of the US National Library of Medicine (NLM), which is a branch of the US National Institutes of Health. ... Swiss-Prot is a curated biological database of protein sequences created in 1986 by Amos Bairoch during his PhD and developed by the Swiss Institute of Bioinformatics and the European Bioinformatics Institute. ... In biology and evolutionary computation, a locus is the position of a gene (or other significant sequence) on a chromosome. ... Chromosome 16 is one of the 23 pairs of chromosomes in humans. ... General Name, Symbol, Number calcium, Ca, 20 Chemical series alkaline earth metals Group, Period, Block 2, 4, s Appearance silvery white Atomic mass 40. ... A representation of the 3D structure of myoglobin, showing coloured alpha helices. ...


The transport of calcium across the enterocyte cytoplasm appears to be rate-limiting for calcium absorption in the intestine; the presence of calbindin increases the amount of calcium crossing the cell without raising the free concentration. Calbindin-D9k may also stimulate the basolateral calcium-pumping ATPases. Expression of calbindin-D9k and calbindin-D28k are both stimulated by the active vitamin D metabolite, calcitriol although the precise mechanisms are still controversial. In mice in which the vitamin D-receptor expression is abolished, calbindin-D9k is reduced but not absent. Vitamin D is a fat soluble vitamin that contributes to the maintenance of normal levels of calcium and phosphorus in the bloodstream. ...


Calbindin describes calcium binding proteins first described as the vitamin D-dependent calcium binding proteins in intestine and kidney. Calbindin-D9k is present in mammalian intestinal epithelial cells (enterocytes) and mediates the transport of calcium across the enterocytes from the apical side, where entry is regulated by the calcium channel TRPV6, to the basolateral side, where calcium pumps such as PMCA1 utilize intracellular ATP to pump calcium into the blood. Calbindin-D28k performs as similar role in the intestine in birds and in the mammalian kidney; it is also found in a number of other neuroendocrine cells, particularly in the cerebellum. Calbindin-D9k can also be found in the kidney and uterus in some mammalian species. Apart from their calcium binding domains, EF-hands, of which calbindin-D9k has two, and calbindin-D28k four, there is no homology between these proteins.


The transport of calcium across the enterocyte cytoplasm appears to be rate-limiting for calcium absorption in the intestine; the presence of calbindin increases the amount of calcium crossing the cell without raising the free concentration. Calbindin-D9k may also stimulate the basolateral calcium-pumping ATPases. Expression of calbindin-D9k and calbindin-D28k are both stimulated by the active vitamin D metabolite, calcitriol although the precise mechanisms are still controversial. In mice in which the vitamin D-receptor expression is abolished, calbindin-D9k is reduced but not absent.


Prounciation


Calbindin is pronounced as "cal bind in" with a "i" sound as in "bind". It is also pronounced as "cal bin din" with an "i" sound as in "bin". What is the correct pronunciation? Given the derivation of the name from calcium binding, the former is technically correct. ==See also==

  • Vitamin D-dependent calcium-binding protein

  Results from FactBites:
 
Schizophrenia Daily News Blog: Calbindin-Immunoreactive Interneurons in Schizophrenia (289 words)
Calbindin is a "calcium binding protein" found mainly in that area of the brain.
Reductions of calbindin proteins in schizophrenia patients have been shown before in other brain regions, such as the prefrontal cortex, anterior cingulate, and hippocampus.
The authors of the current study suggested that reduced calbindin (and consequently, less inhibition of the pyramidal brain cells in the temporal lobe) may have something to do with the auditory and language processing deficits often experienced by people with schizophrenia.
  More results at FactBites »

 
 

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