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Encyclopedia > Caffeine citrate
Image:Caffeine citrate.png
Caffeine citrate
Systematic (IUPAC) name
2-hydroxypropane-1,2,3-tricarboxylic acid; 1,3,7-trimethylpurine-2,6-dione
CAS number 69-22-7
ATC code  ?
PubChem 6241
Chemical data
Formula C14H18N4O9
Mol. weight 386.31
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

? IUPAC nomenclature is a systematic way of naming organic chemical compounds. ... CAS registry numbers are unique numerical identifiers for chemical compounds, polymers, biological sequences and alloys. ... The Anatomical Therapeutic Chemical Classification System is used for the classification of drugs. ... PubChem is a database of chemical molecules . ... A chemical formula (also called molecular formula) is a concise way of expressing information about the atoms that constitute a particular chemical compound. ... The molecular mass of a substance (less accurately called molecular weight and abbreviated as MW) is the mass of one molecule of that substance, relative to the unified atomic mass unit u (equal to 1/12 the mass of one atom of carbon-12). ... In pharmacology, bioavailability is used to describe the fraction of an administered dose of medication that reaches the systemic circulation, one of the principal pharmacokinetic properties of drugs. ... Santorio Santorio (1561-1636) in his steelyard balance, from Ars de statica medecina, first published 1614 Metabolism (from μεταβολισμος (metabolismos)) is the biochemical modification of chemical compounds in living organisms anggjgjhnd cell (b). ... The elimination half-life of a drug (or any xenobiotic agent) refers to the timecourse necessary for the quantity of the xenobiotic agent in the body (or plasma concentration) to be reduced to half of its original level through various elimination processes. ... Excretion is the biological process by which an organism chemically separates waste products from its body. ... The pregnancy category of a pharmaceutical agent is an assessment of the risk of fetal injury due to the pharmaceutical, if it is used as directed by the mother during pregnancy. ...

Legal status
Routes Oral, i.v.

Caffeine citrate (Cafcit®) is a citrate salt of caffeine, sometimes used in medical treatment, including short-term treatment of lack of breathing in premature infants: apnea of prematurity. The regulation of therapeutic goods, that is drugs and therapeutic devices, varies by jurisdiction. ... In pharmacology and toxicology, a route of administration is the path by which a drug, fluid, poison or other substance is brought into contact with the body 1. ... Chemical strucutre of citric acid. ... For other uses, see Caffeine (disambiguation). ... Apnea (British spelling - apnoea) (Greek απνοια, from α-, privative, πνεειν, to breathe) is a technical term for suspension of external breathing. ... Premature birth (also known as preterm birth, or premie) is defined medically as childbirth occurring earlier than 37 completed weeks of gestation. ... Apnea of prematurity is defined as cessation of breathing that lasts for more than 15 seconds and is accompanied by hypoxia or bradycardia. ...

The drug is prepared simply by combining anhydrous caffeine with citric acid monohydrate and sodium citrate dihydrate. In method of action, the prepartation is exactly identical to that of caffeine base as the citrate counter ion dissociates in water. Doses of caffeine citrate, due to the added weight of the citrate moiety, are understandably higher than with caffeine base. The ratio of therapeutic doses of caffeine base to its citrate salt is typically 1:2.

External links

  • Caffiene citrate entry in the NCI Metathesaurus -- warning: even though hosted at a .gov site, this may not be public domain material
  • Drugs.com: Caffeine citrate
  • Link page to external chemical sources.



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