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Encyclopedia > CYP2C9

Cytochrome P450 2C9 (abbreviated CYP2C9), a member of the cytochrome P450 mixed-function oxidase system, is involved in the metabolism of xenobiotics in the body. It is involved in the metabolism of several important groups of drugs including many non-steroidal anti-inflammatory drugs (NSAIDs) and sulfonylureas. Cytochrome P450 Oxidase (CYP2E1) Cytochrome P450 oxidase (commonly abbreviated CYP) is a generic term for a large number of related, but distinct, oxidative enzymes (EC 1. ... A xenobiotic is a chemical which is found in an organism but which is not normally produced or expected to be present in it. ... Non-steroidal anti-inflammatory drugs, usually abbreviated to NSAIDs, are drugs with analgesic, antipyretic and anti-inflammatory effects - they reduce pain, fever and inflammation. ... Sulfonylurea derivatives are a class of antidiabetic drugs that are used in the management of diabetes mellitus type 2 (adult-onset). They act by increasing insulin release from the beta cells in the pancreas. ...


Genetic polymorphism exists for CYP2C9 expression, with approximately 1–3% of Caucasian populations being poor metabolisers with no CYP2C9 function. Look up Caucasian in Wiktionary, the free dictionary Caucasian was originally a geographical term, meaning relative or pertaining to the Caucasus region (Caucasia) of central Eurasia. ...


CYP2C9 Ligands

Selected inducers, inhibitors and substrates of CYP2C91
Type Agent
inducers rifampicin, secobarbital
inhibitors amiodarone, fenofibrate, fluconazole, fluvastatin, fluvoxamine, isoniazid, lovastatin, probenecid, sertraline, sulfamethoxazole, teniposide, voriconazole, zafirlukast
substrates amitriptyline, certain angiotensin II receptor antagonists (losartan, irbesartan), fluoxetine, fluvastatin, NSAIDs (incl. celecoxib, diclofenac, ibuprofen, meloxicam, naproxen, piroxicam), phenytoin, rosiglitazone, sulfonylureas (incl. glibenclamide, glipizide, glimepiride, tolbutamide), tamoxifen, warfarin
Notes:
  1. Where classes of agents are listed, there may be exceptions within the class.

Rifampicin (INN) (IPA: ) or rifampin (USAN) is a bacteriocidal antibiotic drug of the rifamycin group. ... Secobarbital is a Barbiturate and is available as either a free acid or a sodium salt. ... Amiodarone belongs to a class of drugs called Vaughan-Williams Class III antiarrhythmic agent. ... Fenofibrate is a drug of the fibrate class. ... To meet Wikipedias quality standards, this article or section may require cleanup. ... Categories: Stub | Hypolipidemic agents ... Fluvoxamine maleate (sold under the brand-names Luvox® and Faverin®) is a selective serotonin reuptake inhibitor. ... Isoniazid is a first-line antituberculous medication used in the prevention and treatment of tuberculosis. ... Categories: Stub | Hypolipidemic agents ... Probenecid is a uricosuric drug, primarily used in treating gout or hyperuricemia, that increases uric acid removal in the urine. ... Sertraline hydrochloride (Zoloft®, Sertralin®, Lustral®, Apo-Sertral®, Asentra®, Gladem®, Serlift®, Stimuloton®, Xydep®, Serlain®, Concorz®) is an orally administered antidepressant of the selective serotonin reuptake inhibitor (SSRI) type. ... Sulfamethoxazole is a sulfonamide antibiotic. ... Teniposide is a prescribed medication mainly used to treat childhood acute lymphocytic leukemia. ... Voriconazole Voriconazole (Vfend®, Pfizer) is a triazole antifungal medication used to treat serious fungal infections. ... Zafirlukast is an oral leukotriene receptor antagonist (LTRA) for the maintenance treatment of asthma. ... Amitriptyline hydrochloride is an antidepressant drug from the tricyclic antidepressant group, which is sold under the trade names Elavil®, Tryptanol® or Endep®. It is a white, odorless, crystalline compound which is freely soluble in water. ... Angiotensin II receptor antagonists, also known as angiotensin receptor blockers (ARBs) or AT1-receptor antagonists, are a group of pharmaceuticals which modulate the renin-angiotensin-aldosterone system. ... Losartan is a drug used to treat high blood pressure (hypertension). ... Irbesartan is an angiotensin II receptor antagonist used mainly for the treatment of hypertension. ... Fluoxetine hydrochloride is an antidepressant drug used medically in the treatment of depression, obsessive-compulsive disorder, bulimia nervosa, premenstrual dysphoric disorder and panic disorder. ... Categories: Stub | Hypolipidemic agents ... Non-steroidal anti-inflammatory drugs, usually abbreviated to NSAIDs, are drugs with analgesic, antipyretic and anti-inflammatory effects - they reduce pain, fever and inflammation. ... Celecoxib is a non-steroidal anti-inflammatory drug (NSAID) used in the treatment of osteoarthritis, rheumatoid arthritis, acute pain, painful menstruation and menstrual symptoms, and to reduce numbers of colon and rectum growths polyps in patients with familial adenomatous polyposis. ... Diclofenac (marketed as Voltaren®, Voltarol®, Diclon® and Cataflam®) is a non-steroidal anti-inflammatory drug (NSAID) taken to reduce inflammation, such as in arthritis or acute injury. ... Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) widely marketed under various trademarks including Act-3, Advil, Brufen, Motrin, Nuprin, and Nurofen. ... Meloxicam is a nonsteroidal anti-inflammatory drug used to relieve the symptoms of arthritis, primary dysmenorrhoea, pyrexia; and as an analgesic, especially where there is an inflammatory component. ... Naproxen (trade names: Aleve, Anaprox, Naprogesic, Naprosyn, Naprelan) is a non-steroidal anti-inflammatory drug (NSAID) commonly used for the reduction of mild to moderate pain, fever, inflammation and stiffness caused by conditions such as osteoarthritis, rheumatoid arthritis, psoriatic arthritis, gout, ankylosing spondylitis, injury, menstrual cramps, tendinitis, bursitis, and the... Piroxicam (US trade name Feldene) is a nonsteroidal anti-inflammatory drug used to relieve the symptoms of arthritis, primary dysmenorrhoea, pyrexia; and as an analgesic, especially where there is an inflammatory component. ... Phenytoin sodium (marketed as Dilantin® in the USA and as Epanutin® in the UK, by Parke-Davis, now part of Pfizer) is a commonly used antiepileptic. ... Rosiglitazone is an anti-diabetic drug from the thiazolidinedione class. ... Sulfonylurea derivatives are a class of antidiabetic drugs that are used in the management of diabetes mellitus type 2 (adult-onset). They act by increasing insulin release from the beta cells in the pancreas. ... Glibenclamide is a class of drug known as sulphonylureas. ... Glipizide is an oral medium-to-long acting anti-diabetic drug from the sulfonylurea class. ... Glimepiride is a medium-to-long acting sulfonylurea anti-diabetic drug. ... Tolbutamide is a sulfonylurea oral hypoglycemic drug sold under the brand name Orinase. ... Tamoxifen:chemical structure Tamoxifen is an oral selective estrogen receptor modulator which is used in breast cancer treatment, and is currently the worlds largest selling breast cancer treatment. ... Warfarin (also known under the brand names of Coumadin® and Marevan®) is an anticoagulant medication that is administered orally. ...

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