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Encyclopedia > C fiber

C-fibers are unmyeliniated and as a result, have a slower conduction velocity, lower than 2 m/s. These fibers are associated with chronic or dull pain. C-fibers are associated with sensations of cold, as well as mechanical and chemical stimuli. The density for cold receptors in the skin is greater than the density of warm-receptors (by a factor of 5). It is thought that most or all C fibers are nociceptors (responding only to noxious stimuli). Chronic pain was originally defined as pain that has lasted 6 months or longer. ... A nociceptor is a sensory receptor that sends signals that cause the perception of pain in response to potentially damaging stimulus. ...


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Triple C Syndrome (164 words)
The Triple C Syndrome occurs when the C fiber, by reflex becomes super sensitive to an underlying injury of the "A delta" nerve fiber.
Since the C fiber is trying to limit the effect of this injury, it intensely fires, causing vasoconstriction.
Sympathetic blockade is fruitless as once the block wears off, the C fiber remains hyperactive in response to the underlying A delta injury.
Dimethyl Sulfoxide (DMSO) Blocks Conduction in Peripheral Nerve C Fibers: a Possible Mechanism of Analgesia (2471 words)
C fiber responses were identified by their slower conduction velocity, smaller amplitude and higher stimulus threshold compared to A fibers.
A fiber responses at the beginning of the record are distorted because of the high gain (which saturates the signal averager) and slow timebase needed to demonstrate C responses.
C fiber compound action potential amplitude (most positive point minus most negative point) and latency (to most positive point) were measured.
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