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Encyclopedia > César Milstein

César Milstein (1927-2002) was born in Bahia Blanca, Argentina. He graduated from the University of Buenos Aires and obtained a PhD under Professor Stoppani (Professor of Biochemistry) in the Medical School on kinetic studies with the enzyme aldehyde dehydrogenase. In 1958, funded by the British Council, he joined the Biochemistry Department at the University of Cambridge to work for a PhD under Malcolm Dixon on the mechanism of metal activation of the enzyme phosphoglucomutase. During this work he collaborated with Frederick Sanger whose group he joined with a short-term Medical Research Council appointment. 1927 was a common year starting on Saturday (link will take you to calendar). ... 2002 is a common year starting on Tuesday of the Gregorian calendar. ... Bah a Blanca is a city in eastern Argentina in Buenos Aires Province and a seaport at the head of the Bah Blanca (White Bay - an arm of the Atlantic Ocean). ... The Universidad de Buenos Aires (UBA) is the biggest university in Argentina, founded on August 12, 1821 in the city of Buenos Aires. ... Doctor of Philosophy (Ph. ... A professor is a senior teacher and researcher, usually in a college or university. ... Biochemistry is the chemistry of life. ... Medical school generally refers to a tertiary educational institution (or part of such an institution) which is involved in the education of future medical practitioners (medical doctors). ... Figure 1: Diagram of a catalytic reaction, showing the energy needed at each stage of the reaction. ... Neuraminidase ribbon diagram An enzyme (in Greek en = in and zyme = leaven) is a protein, or protein complex, that catalyzes a chemical reaction and also controls the 3D orientation of the catalyzed substrates. ... 1958 was a common year starting on Wednesday (link will take you to calendar). ... The British Council is a partly UK Government_funded cultural relations organisation and a registered charity in the UK. It aims to build mutually beneficial cultural and educational relationships between people in the UK and in other countries, and increase appreciation of the UKs creative ideas and achievements. ... Biochemistry is the chemistry of life. ... The University of Cambridge is the second-oldest university in the English-speaking world. ... Phosphoglucomutase (EC 5. ... This article or section should be merged with Fred Sanger Frederick Sanger OM (born August 13, 1918) is a British molecular biologist who was working on problems related to the determination of the structure of proteins. ... Current MRC logo The Medical Research Council (MRC) is a UK organisation dedicated to promot[ing] the balanced development of medical and related biological research in the UK. Organisation The MRC is one of seven Research Councils and is answerable to, although politically independent from, the Office of Science and...


In 1975, Milstein and Köhler described the hybridoma technique for producing monoclonal antibodies. They immortalised antibody producing cells by fusing them with tumour cells. The resulting antibody cell and all its daughter cells produce identical antibody molecules. The method allows unlimited production of monoclonal antibodies with predetermined specificity. In recognition of this, he won a Nobel Prize in Medicine and Physiology in 1984 (shared with Georges J.F. Köhler and Niels Kaj Jerne), "for work on the immune system and the production of monoclonal antibodies". 1975 was a common year starting on Wednesday (the link is to a full 1975 calendar). ... Monoclonal antibodies (mAb) are antibodies that are identical because they were produced by one type of immune cell, all clones of a single parent cell. ... Monoclonal antibodies (mAb) are antibodies that are identical because they were produced by one type of immune cell, all clones of a single parent cell. ... Schematic of antibody binding to an antigen An antibody is a protein used by the immune system to identify and neutralize foreign objects like bacteria and viruses. ... List of Nobel Prize laureates in Physiology or Medicine from 1901 to the present day. ... 1984 is a leap year starting on Sunday of the Gregorian calendar. ... Georges Jean Franz Köhler (March 17, 1946 in Munich - March 7, 1995 in Freiburg im Breisgau) was a German biologist. ... Niels Kaj Jerne (December 23, 1911 - October 7, 1994) was a British-Danish-Swedish (English-born) immunologist. ... The immune system is the organ system that protects an organism from outside biological influences. ... Monoclonal antibodies (mAb) are antibodies that are identical because they were produced by one type of immune cell, all clones of a single parent cell. ...


He was elected a Fellow of the Royal Society in 1975 and became a Companion of Honour in 1995. The Royal Society of London is claimed to be the oldest learned society still in existence and was founded in 1660. ... 1975 was a common year starting on Wednesday (the link is to a full 1975 calendar). ... The Order of the Companions of Honour is a British and Commonwealth Order (decoration). ... 1995 was a common year starting on Sunday of the Gregorian calendar. ...


César Milstein died in March 2002 in Cambridge, United Kingdom, aged 74. The city of Cambridge is an old English university town and the regional centre of the county of Cambridgeshire. ...

  • theories concerning the specificity in development and control of the immune system and the discovery of the principle for production of monoclonal antibodies. (http://okilpob.tripod.com/mkdir/milstein-press.html)

 
 

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