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Encyclopedia > Bursa of Fabricius

In birds, the bone marrow is the site of hematopoiesis and the bursa of Fabricius (Latin: Bursa cloacalis or Bursa fabricii) is a specialized organ that, as first demonstrated by Bruce Glick and later by Max Cooper and Robert Good, is necessary for B cell development. Mammals generally do not have an equivalent organ; the bone marrow is often both the site of hematopoesis and B cell development. Orders Many - see section below. ... Bone marrow (or medulla ossea) is the tissue comprising the center of large bones. ... Haematopoiesis is the formation of blood cellular components. ... Latin is an Indo-European language originally spoken in the region around Rome called Latium. ... In biology, an organ (Latin: organum, instrument, tool) is a group of tissues, which perform a specific function or group of functions. ... Orders Subclass Multituberculata (extinct) Plagiaulacida Cimolodonta Subclass Palaeoryctoides (extinct) Subclass Triconodonta (extinct) Subclass Placentalia Afrosoricida Artiodactyla Carnivora Cetacea Chiroptera Cimolesta (extinct) Creodonta (extinct) Condylarthra (extinct) Dermoptera Desmostylia (extinct) Embrithopoda (extinct) Hyracoidea Insectivora Lagomorpha Litopterna (extinct) Macroscelidea Mesonychia (extinct) Notoungulata (extinct) Perissodactyla Pholidota Plesiadapiformes (extinct) Primates Proboscidea Rodentia Scandentia Sirenia Taeniodonta...


The ‘B’ in ‘B cell’ refers to bursa-derived. This is simply because during the 1960s B cells were first defined (and distinguished from thymus-derived T cells) in birds, which have a bursa. A decade later, after examining almost every other organ including the appendix, researchers finally discovered that mammalian B cells develop in the bone marrow. The fact that ‘bone marrow’, like bursa, starts with a ‘B’ is a (fortunate?) coincidence.


  Results from FactBites:
 
ON USE OF SIZE OF THE BURSA OF FABRICIUS AS AN INDEX OF AGE AND DEVELOPMENT (2187 words)
For bursa and gonad dimensions, I measured length and width using dial calipers and I measured wing lengths by centimeter ruler.
Chronological study of bursa involution in each species must be made before the size of the bursa of Fabricius is used to quantify specimen age.
The bursa of Fabricius ("bursa") is a dorsal diverticulum of the cloaca, has a lympho-epithelial origin, and functions as an early immunosup- pressive organ (Glick 1983).
Perinatal Deletion of B Cells Expressing Surface Ig Molecules That Lack V(D)J-Encoded Determinants in the Bursa of ... (5678 words)
The bursa of Fabricius is the primary lymphoid organ responsible
the lymphoid follicles of the bursa (33, 34, 35, 36).
Because bursal follicles in the embryonic bursa are oligoclonal,
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