FACTOID # 29: 73.3% of America's gross operating surplus in motion picture and sound recording industries comes from California.
 
 Home   Encyclopedia   Statistics   States A-Z   Flags   Maps   FAQ   About 
   
 
WHAT'S NEW
 

SEARCH ALL

FACTS & STATISTICS    Advanced view

Search encyclopedia, statistics and forums:

 

 

(* = Graphable)

 

 


Encyclopedia > Borna disease


Borna disease virus
Virus classification
Group: Group V ((-)RNA)
Order: Mononegavirales
Family: Bornaviridae
Genus: Bornavirus
Species: Borna disease virus

Borna disease is an infectious neurological syndrome of warm-blooded animals, which causes abnormal behaviour and fatality. Originally identified in sheep and horses in Europe, it has since been found to occur in a wide range of warm-blooded animals including birds, cattle, cats and primates and has been found in animals in Europe, Asia, Africa and North America. The name is derived from the town of Borna in Saxony, Germany, which suffered an epidemic of the disease in horses in 1885.


Borna disease in sheep and horses arises after a four week incubation period followed by the development of immune-mediated meningitis and encephalomyelitis. Clinical manifestations vary but may include excited or depressed behaviour, ataxia, ocular disorders and abnormal posture and movement. Mortality rates are 80-100% in horses and greater than 50% in sheep.


The causative agent of Borna disease, Borna disease virus (BDV) is a neurotropic virus and is the sole member of the Bornaviridae family within the Mononegavirales order. It has the smallest genome (8.9 kilobases) of any Mononegavirales species and is unique within that order in its ability to replicate within the host cell nucleus.


The mode of transmission of BDV is unclear but probably occurs through intranasal exposure to contaminated saliva or nasal secretions. Following infection, individuals may develop Borna disease, or may remain subclinical, possibly acting as a carrier of the virus.


BDV also infects humans and is therefore considered to be a zoonotic agent. The role of BDV in human illness is controversial and it is yet to be established whether BDV causes any overt disease in humans. However, correlative evidence exists linking BDV infection with neuropsychiatric disorders such as bipolar disorder.


References

Koprowski, H. and Lipkin, W. I. (Eds) (1995). Borna disease. Springer-Verlag.




  Results from FactBites:
 
APHIS | News (754 words)
Borna disease is a sporadic, transmissible, progressive neurologic disease of horses, cats, cattle, and sheep.
Borna disease is a subacute, viral encephalomyelitis, which is a type of brain infection.
Microscopically, the disease is characterized by an inflammation of nerve cells in the brain.
  More results at FactBites »

 
 

COMMENTARY     


Share your thoughts, questions and commentary here
Your name
Your comments

Want to know more?
Search encyclopedia, statistics and forums:

 


Press Releases |  Feeds | Contact
The Wikipedia article included on this page is licensed under the GFDL.
Images may be subject to relevant owners' copyright.
All other elements are (c) copyright NationMaster.com 2003-5. All Rights Reserved.
Usage implies agreement with terms, 1022, m