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Encyclopedia > Biogen Idec
Biogen Idec, Inc.
Type Public (NASDAQBIIB)
Founded 2003
Headquarters Cambridge, Massachusetts
Key people Jim Mullen, CEO
Industry Biotechnology
Products Rituxan, Zevalin, Avonex, Tysabri
Revenue 2.26 billion USD
Employees 4,166
Website http://www.biogenidec.com

Biogen Idec, Inc. (NASDAQBIIB) is a biotechnology company specializing in drugs for neurological disorders, autoimmune disorders and cancer. The company was formed in 2003 by the merger of Cambridge, Massachusetts-based Biogen and San Diego, California-based Idec Pharmaceuticals. Image File history File links Biogen Idec logo. ... This article does not cite any references or sources. ... NASDAQ in Times Square, New York City. ... Year 2003 (MMIII) was a common year starting on Wednesday of the Gregorian calendar. ... Location in Massachusetts Coordinates: , Country United States State Massachusetts County Middlesex County Settled 1630 Incorporated 1636 Government  - Type Mayor-council city  - Mayor Kenneth Reeves (D) Area  - City  7. ... The structure of insulin Biological technology is technology based on biology, especially when used in agriculture, food science, and medicine. ... Rituximab, sold under the trade names Rituxan® and Mabthera®, is a monoclonal antibody used in the treatment of B cell non-Hodgkins lymphoma, a kind of cancer. ... Ibritumomab Tiuxetan , also sold under the trade name Zevalin® is a monoclonal antibody radioimmunotherapy treatment for some forms of non-Hodgkins lymphoma, a myeloproliferative disorder of the lymphatic system. ... Avonex is an interferon drug developed by the Biogen Idec pharmaceutical company for use in the treatment of relapsing/recurring Multiple Sclerosis. ... Tysabri (natalizumab), co-marketed by Biogen Idec and Elan, is a monoclonal antibody that has proven efficacy in the treatment of two serious autoimmune disorders: Multiple Sclerosis (MS) and Crohns Disease (CD). ... Look up revenue in Wiktionary, the free dictionary. ... The United States dollar is the official currency of the United States. ... For the album by the Kaiser Chiefs see Employment (album) Employment is a contract between two parties, one being the employer and the other being the employee. ... A website (alternatively, Web site or web site) is a collection of Web pages, images, videos and other digital assets that is hosted on one or several Web server(s), usually accessible via the Internet, cell phone or a LAN. A Web page is a document, typically written in HTML... NASDAQ in Times Square, New York City. ... The structure of insulin Biological technology is technology based on biology, especially when used in agriculture, food science, and medicine. ... Neurology is a branch of medicine dealing with disorders of the nervous system. ... Autoimmune diseases arise from an overactive immune response of the body against substances and tissues normally present in the body. ... Cancer is a class of diseases or disorders characterized by uncontrolled division of cells and the ability of these to spread, either by direct growth into adjacent tissue through invasion, or by implantation into distant sites by metastasis (where cancer cells are transported through the bloodstream or lymphatic system). ... Year 2003 (MMIII) was a common year starting on Wednesday of the Gregorian calendar. ... The phrase mergers and acquisitions or M&A refers to the aspect of corporate finance strategy and management dealing with the merging and acquiring of different companies as well as assets. ... Location in Massachusetts Coordinates: , Country United States State Massachusetts County Middlesex County Settled 1630 Incorporated 1636 Government  - Type Mayor-council city  - Mayor Kenneth Reeves (D) Area  - City  7. ... Nickname: Location of San Diego within San Diego County Coordinates: , Country United States State California County San Diego Founded July 16, 1769 Incorporated March 27, 1850 Government  - Mayor Jerry Sanders  - City Attorney Michael Aguirre  - City Council Scott Peters Kevin Faulconer Toni Atkins Tony Young Brian Maienschein Donna Frye Jim Madaffer...

Biogen Idec stock is a component of several stock indices such as the S&P 500, S&P 1500, and NASDAQ-100. It employs a little over 4,000 employees. The S&P 500 is an index containing the stocks of 500 Large-Cap corporations, most of which are American. ... The S&P 1500, or S&P 1500 Composite Index, is a stock market index of US stocks made by Standard & Poors. ... The NASDAQ-100 is a stock market index of 100 of the largest domestic and international non-financial companies listed on the NASDAQ stock exchange based on market capitalization. ...


Locations of operation

Biogen Idec is headquartered in Kendall Square in Cambridge, Massachusetts, and operates research and development facilities in Cambridge and San Diego. Biogen Idec operates manufacturing facilities in Kendall Square, in Research Triangle Park, North Carolina, and Hoofddorp, Netherlands. The company is also building a Large Scale Manufacturing plant in Hillerod, Denmark, which is expected to go online in 2008. Kendall Square is a neighborhood in Cambridge, Massachusetts, located at the intersection of Main Street, Broadway, Wadsworth Street, and Third Street (known as Kendall Square). It may also refer to the broad business district that is west of Portland Street, east of Charles River, north of MIT and south of... The phrase research and development (also R and D or R&D) has a special commercial significance apart from its conventional coupling of scientific research and technological development. ... Kendall Square is a neighborhood in Cambridge, Massachusetts, located at the intersection of Main Street, Broadway, Wadsworth Street, and Third Street (known as Kendall Square). It may also refer to the broad business district that is west of Portland Street, east of Charles River, north of MIT and south of... Research Triangle Park, or RTP is a research park near Raleigh, Durham, and Chapel Hill, in the Research Triangle region of North Carolina. ...

Biogen Idec maintains its international headquarters in Zug, Switzerland, and operates an International regulatory & clinical center of excellence in Maidenhead, UK. In Europe, Biogen Idec has direct commercial affiliates in Germany, France, Spain/Portugal, UK/Ireland, the Benelux, Sweden, Denmark, Norway, Finland, and Austria. In Italy and in Switzerland, Biogen Idec markets its products through two joint venture companies set up with the privately held Italian company Dompe Biotec. Biogen Idec also has offices in Canada, Australia, and Japan.  , capital of the Swiss canton of that name, is a picturesque little town at the northeastern corner of the lake of Zug, and at the foot of the Zugerberg (992 m (3255 ft. ... Location of Benelux in Europe Official languages Dutch and French Membership  Belgium  Netherlands  Luxembourg Website http://www. ...


Biogen Idec's principal competitors include Teva, Serono, and Schering AG/Berlex. Teva Pharmaceutical Industries Ltd. ... Serono is a biotechnology company headquartered in Geneva, Switzerland. ... Schering AG (FWB: SCH, (NYSE: SHR)) is a research-centered pharmaceutical company founded in 1851. ... // Berlex Laboratories, Incorporated is a research-based pharmaceutical company headquartered in Montville, New Jersey with operations in Wayne, New Jersey; Bothell, Washington; Seattle, Washington; and Richmond, California. ...

As of 2004, Biogen Idec derives most of its income from sales of multiple sclerosis treatment Avonex and from partnership royalties on Rituxan from Genentech, which markets Rituxan in the US. Roche markets Rituxan outside the US as MabThera. 2004 is a leap year starting on Thursday of the Gregorian calendar. ... Interferon beta-1a is a drug in the interferon family used to treat multiple sclerosis. ... Genentech, Inc. ... Rituximab, sold under the trade names Rituxan® and MabThera®, is a monoclonal antibody used in the treatment of B cell non-Hodgkins lymphoma, B cell leukemia, and some autoimmune disorders. ...


BIIB is managed day-to-day by an executive group composed of nine officers. As customary for a publicly-traded company, BIIB is also overseen by a board of directors that votes on important company decisions. The executive chairman and chief executive officer both hold positions on the board of directors.

Chairman of the Board: Bruce R. Ross
President, Chief Executive Officer: James C. Mullen
President, Research and Development: Cecil B. Pickett
Executive Vice President, Development: Burt A. Adelman
Executive Vice President, New Ventures: John M. Dunn
Executive Vice President, Finance and Chief Financial Officer: Paul Clancy
Executive Vice President, Corporate Strategy and Communication: Connie L. Matsui
Executive Vice President, Human Resources: Craig Eric Schneier, Ph.D.
Executive Vice President, Business Development: Mark Wiggins
Directors: Alan Belzer, Lawrence C. Best, Alan B. Glassberg, Mary L. Good, Thomas F. Keller, Robert W. Pangia, Bruce R. Ross, The Honorable Lynn Schenk, Phillip A. Sharp, Willian D. Young

Company Perspectives:

Birth of a Biotech Pioneer

Biogen is considered one of the pioneers of the biotechnology industry. It got its start in 1978 when Walter H. Gilbert, a Nobel prize-winning biologist who was teaching at Harvard at the time, decided to try developing his research into marketable products. Biotechnology, as it was known in the mid-1970s, was still in its infancy. The discovery of the structure of DNA, which led to the understanding of the process by which proteins are produced by cells, had occurred in 1953. But it was not until the early 1970s that more rapid progress ensued. Significantly, in 1973 two U.S. scientists discovered the process of recombinant DNA, whereby a piece of DNA is snipped from one gene and spliced into another gene. The significance of that discovery was that it proved that scientists could genetically alter microorganisms and, particularly important, produce mass amounts of proteins that naturally occurred only in small quantities.

Walter Gilbert had been a major contributor to the development of recombinant DNA technology during the 1970s, and he had earned his Nobel prize as a result of his research in that area. Subsequent related breakthroughs during the middle and late 1970s indicated that scientists would eventually be able to use gene-splicing and cloning techniques to create various 'wonder' drugs and products that could, among other benefits, cure cancer and many other diseases or create perfect produce and livestock with fantastic characteristics. Despite the promise of the technology, a recognizable industry that could develop such drugs and take them to market was slow to form. Before 1980, in fact, only a few significant biotech start-ups had appeared: Cetus (founded in 1971); Genentech (1976); Genex (1977); Biogen (1978); Centocor (1979); and Amgen (1980).

Biogen, like its biotech peers, was able to capitalize on the belief of some investors during the late 1970s that biotechnology was going to radically impact many areas of industry, medicine, food, energy, and agriculture. Although Biogen and some other companies made significant contributions to the burgeoning field of biotech, it was not until the 1980s that the industry boomed. The growth was in large part the result of a U.S. Supreme Court ruling that genetically engineered bacterium could be patented. For many, that ruling suggested the possibility of unimaginable wealth for biotech innovators. As a result, millions of dollars poured into the industry, primarily through venture capital but also through the sale of publicly traded stock. Companies that showed promise, such as Biogen, benefited the most.

Biogen launched a number of research initiatives during the late 1970s and early 1980s related to a variety of healthcare drugs. Some efforts fizzled, but, unlike many other biotech start-ups, Biogen eventually succeeded in generating some marketable products. The two biggest winners were a hepatitis B vaccine and alpha interferon. The hepatitis B vaccine was, as its name implies, a vaccine for hepatitis B, a blood-borne disease that causes a serious infection of the liver and substantially increases the risk of liver cancer; more than 250 million people worldwide still suffered from chronic hepatitis B virus infections in the early 1990s. Biogen eventually obtained patents in several countries related to its hepatitis B antigens produced by genetic engineering techniques, and the drug--marketed by SmithKline Beecham plc and Merck & Co., Inc.--became a big seller. In many countries, in fact, infants were commonly vaccinated against hepatitis B using Biogen's drug.

Alpha interferon was an even bigger source of revenue for Biogen. Alpha interferon is a naturally occurring protein produced by normal white blood cells. Biogen developed and patented a process of producing vast amounts of the protein using recombinant DNA techniques. Its alpha interferon compound became the first genetically engineered drug to receive market approval in the United States. Biogen's alpha interferon, also known as Intron A, was eventually being sold by licensee Schering-Plough Corporation in more than 60 countries to treat a variety of conditions including hepatitis B, hepatitis C, genital warts, Kaposi's sarcoma (an AIDS-related cancer), and hairy-cell leukemia.

== 1980s: Near Bankruptcy, Then Recovery ==

Biogen racked up major points in the research and development game during the early 1980s, and positive press brought tens of millions of dollars into its coffers. Like most biotechnology companies, though, Biogen was burning through the cash as fast, or faster, than it poured in (the company went public in 1983). CEO Gilbert, in his quest for new genetically engineered drugs, established a global research and development network during the early 1980s that sported operations in Zurich, Geneva, Belgium, Germany, and the United States. Although impressive and sometimes effective, the organization eventually became unwieldy and lacked focus. Some critics charged that despite his scientific prowess, Gilbert lacked business skills. The company was a great place to do research, but it had yet to show a profit. By 1984, in fact, Biogen had racked up a stunning $100 million in losses and was teetering on the edge of bankruptcy.

Gilbert managed to keep Biogen afloat during the early 1980s by licensing other companies to manufacture, market, and distribute its drugs. To make ends meet, he also started selling Biogen's patents. Some criticized the move as representing a sellout of the company's technological achievements; Biogen's original goal, in fact, had been both to develop and manufacture its inventions. Instead, the company had essentially become a research boutique that supplied drug companies in Europe, Japan, and the United States with technology. In the end, however, Gilbert's licensing and selling was credited with saving the company from total bankruptcy. Indeed, many of Biogen's scientifically savvy biotech start-up peers were effectively forced out of business--often through merger or acquisition--because of financial difficulties.

By 1985 Biogen was using an estimated $100,000 each day in research costs. Furthermore, royalty revenues had slid to less than $20 million annually because the company had sold some of its patents. Biogen investors were fed up; the company's directors had already, in fact, pulled Gilbert from the chief executive slot and had been searching for a replacement for more than a year. Finally, in 1985, they hired James L. Vincent. Vincent graduated from Duke University, where he had been recruited to play football but did not because of a neck injury. He earned his M.B.A. at Wharton before joining Bell Telephone Company of Pennsylvania. From there he served in various positions including president of Texas Instruments-Asia, chief operating officer at Abbott Laboratories, and president of Allied Health and Scientific Products Company. He was known as a hard-charging, imposing, and capable manager.

Biogen began a radical restructuring and turnaround under Vincent's command. Soon after arriving at Biogen, Vincent sold or closed the European operations and brought in some new managers. Significantly, he also began working to recover some of the patents that the company had sold off during the early 1980s. By the time Vincent arrived, in fact, Biogen had sold off nearly 90 percent of its patents. Vincent succeeded in negotiating with companies to get or buy back most of those patents. By 1989 Biogen had regained control of 90 percent of all of its original patents. As Vincent got back the rights to the company's technology, he started licensing them to other manufacturers. The result was that the company's royalty revenues increased and Biogen's balance sheet gradually began to move back toward solvency.

The impact of Vincent's efforts was slow to materialize. Biogen lost more than $70 million between 1985 and 1988, and gross revenues actually plummeted to a low of about $8.5 million in 1987 after net income dipped to a $28 million deficit in 1986. But Biogen started to spring back in the late 1980s. Sales reached $28.5 million in 1989, and the company posted its first-ever profit--a $3.2 million surplus. Revenues surpassed $50 million in 1990 and then hit $61 million in 1991, by which time the company was generating net income of more than $7 million annually. That growth was in part attributable to new additions to Biogen's product line. By 1991 the company was selling through licensees several different drugs that were generating global sales of about $600 million annually: Intron A Alpha Interferon, Hepatitis B vaccine, Hepatitis B diagnostics, and Gamma Interferon (used to treat renal cell carcinoma).

1990s and Beyond: Moving from Licensor to Manufacturer and Marketer

Biogen benefited in 1992 from heady gains in sales of several of its drugs, particularly alpha interferon. The company stunned analysts, in fact, by reporting revenues of $123.8 million for the year and an increase of more than 500 percent in its net income to $38.3 million. The company expected those gains to continue in the near future. Furthermore, Biogen had several new products in its research and development pipeline that had the potential to add big sums to its bottom line. The most promising of its drugs going into the mid-1990s was Hirulog, a blood thinner derived from leeches. Hirulog, which acted as a direct inhibitor of Thrombin (the main enzyme that coagulates blood), was designed to provide immediate relief to people with severe and sudden chest pains, and to prevent clotting complications after veins were opened up through balloon angioplasty or coronary bypass surgery. Biogen had invested heavily in Hirulog and was trying to gain Food and Drug Administration (FDA) approval to market it.

The Hirulog project represented Biogen's drive to become a manufacturer and marketer, rather than just a developer and licensor, of drugs. Simultaneously, Biogen was seeking approval for a drug that it had developed and wanted to manufacture called interferon beta-1a (the trade name of which was Avonex), designed as a treatment for relapsing multiple sclerosis. Both drugs were in the final stages of clinical testing in mid-1994. If approved, they would usher Biogen into a new era as a full-fledged pharmaceutical company that developed and sold its own drugs and products. Moreover, Vincent had been beefing up Biogen's management and sales force to prepare for their approval. To that end, in January 1994 he had conducted a major coup by recruiting James R. Tobin to Biogen's management ranks to serve in the newly created position of president and chief operating officer.

The 49-year-old Tobin had previously spent 21 years at pharmaceutical giant Baxter International Inc., where he rose from a financial analyst to president of the company. Tobin received his master's degree from Harvard Business School before joining Baxter. He was apparently being groomed to assume the chief executive position at Baxter when he decided that he was looking for a different kind of challenge. Tobin was considered a heavy hitter in the pharmaceutical industry, and his move to Biogen gave that company a new respect in the industry. Tobin's job at Biogen would be to shepherd the company from a licensor to a manufacturer and marketer of drugs. Shortly before he arrived, Biogen posted record revenues of $136.5 million for the year and net income of about $32.5 million.

Biogen entered 1994 with high hopes. Its dreams were temporarily stalled, however, by a string of setbacks. In the fall of 1994, Biogen announced that it was discontinuing its efforts to bring Hirulog to market because of disappointing test results. That news was greeted by shareholder lawsuits alleging securities violations for stopping work on the drug. Then, early in January 1995, news came that German pharmaceutical giant Schering AG (since World War II, not affiliated with Schering-Plough and now called Bayer Schering Pharma) announced plans to produce interferon beta-1b (unlike Avonex, which Biogen "acquired" from its joint venture with Rentschler, nonglycosylated), Biogen's other breakthrough drug, using a bacterial expression system instead of hamster cells as used by Biogen. Biogen, however, maintained that it had access to all patents necessary to market Avonex interferon beta-1a, even though the protein was not similar to the protein that had been tested clinically by Biogen and Rentschler. Nevertheless, the news sent Biogen's stock price tumbling by only $7 to $35.37, which was down from a high of $55.75 before the Hirulog setback.

In large part because of writeoffs related to Hirulog, Biogen posted a net loss of $4.9 million from revenues of $156.34 million. The company's problems were exacerbated early in 1995 when pricing changes in Japan of the alpha interferon that Biogen developed and licensed to Schering-Plough Corp. contributed to a significant reduction in first-quarter profits. However, that news only marginally affected the company's stock price, as Biogen's balance sheet easily withstood the hit. Indeed, Biogen's gains during the early 1990s had put it in excellent financial shape. The company entered the mid-1990s cash-rich and among the healthiest biotechnology companies in the country. It was still generating revenues from licensing its marketable drugs, and some of those products were positioned well to benefit from market changes. It also had a number of promising products in development, although they had not yet progressed past the clinical, or final, stage of premarket testing.

In May 1996, in a key event in the company's history, Biogen announced that the FDA had unanimously approved Biogen's Avonex interferon beta-1a drug for treating relapsing forms of multiple sclerosis. Studies had found that Avonex was, in the words of Biogen CEO Vincent, 'the first and only drug to show in a blinded clinical trial that it slows the progression of [MS] disability as well as reduces the frequency of exacerbations.' Thanks to 18 months of planning following the preliminary FDA approval, Biogen began marketing Avonex in the United States within 35 hours of final FDA approval. A successful launch was jeopardized, however, by a lawsuit filed by Schering AG, which had begun selling its beta interferon drug in the United States in 1995 under the name Betaseron. When approving it in 1993, the FDA had given Schering rights to exclusivity vis-à-vis Betaseron under the federal Orphan Drug Act (so-called 'orphan drug status'); in an unprecedented move three years later, however, the agency gave parallel orphan drug status to Avonex because of the latter's method of injection, which reduced skin side effects. Schering sued the FDA, but in October 1996 a federal judge dismissed the suit, agreeing with the FDA that Avonex was 'clinically superior' to Betaseron and, therefore, deserving of parallel protection, as stipulated in the Orphan Drug Act. By late 1996 Avonex was outselling Betaseron in the United States, with more than 60 percent of new prescriptions being written for the Biogen treatment.

The launch of Avonex helped increase sales at Biogen from $134.7 million in 1995 to $259.7 million in 1996, an increase of nearly 93 percent. Net income was a record $40.5 million. In early 1997 Tobin was promoted to president and CEO, with Vincent remaining chairman. That year, the company began marketing Avonex in the European Union, despite its loss in a patent battle with Schering in Europe. Litigation between Biogen and Schering over their beta interferon products continued into the early 21st century, clouding Biogen's future. Also hanging over Biogen was a lack of new products in the pipeline for introduction by 1998 and 1999 as well as the potential for falling income from royalties starting in 2000. Partly in response, Biogen entered into an agreement with Merck to develop small molecule inhibitors for the treatment of asthma and other diseases. As part of the deal, Merck agreed to pay Biogen as much as $145 million over several years, representing a significant cash infusion.

Biogen was a 1998 recipient of the National Medal of Technology, so honored for developing pharmaceuticals 'designed to treat large, previously underserved patient populations throughout the world'--and particularly for its development of hepatitis B vaccines, which were the first vaccines using recombinant DNA technology. Soon after the announcement of this prestigious award, however, the company was rocked by the sudden departure of Tobin. The president and CEO had clashed with Vincent and had demanded a freer hand from the company board. The board refused, leading to Tobin's resignation. Vincent was named interim CEO, and James C. Mullen, a ten-year company veteran who had been in charge of European operations, was promoted to president and COO in February 1999. Meantime, Biogen recorded record net income of $138.7 million on record revenues of $557.6 million. Sales of Avonex were $394 million, or more than 70 percent of the total.

With Avonex's orphan drug status set to expire in 2003 and Serono Laboratories about to bring a more effective interferon-beta-1a to market in the United States, Biogen needed to bring additional products to market. The company suffered a setback in late 1999 when it halted trials of Antova, an immune system regulator, after some patients participating in the trials developed blood clots. Proceeding more smoothly through the approval process, however, was Amevive, a drug to treat the skin disease psoriasis. Biogen hoped to get FDA approval by early 2002. Also in the pipeline was a congestive heart failure treatment called Adentri. The company was investigating other potential uses of its blockbuster Avonex drug, the sales of which reached $621 million in 1999 in part because of geographic market expansion. In early 2000 Biogen announced that Avonex had proven effective in delaying the development of multiple sclerosis in people showing early signs of the disease. The company immediately moved to gain approval from the FDA and other regulatory agencies worldwide to expand the drug's prescription labeling to include these potential new patients. In June 2000 Mullen was promoted to president and CEO, with Vincent continuing as chairman. Mullen, therefore, assumed the important responsibility for shepherding the follow-up to Avonex through the pipeline.


 * 2007: Biogen Idec acquires Syntonix Pharmaceuticals adding hematology programs to the pipeline. Syntonix is operated as a wholly-owned subsidiary of Biogen Idec. * 2006: European Commission approves TYSABRI® (natalizumab) for the treatment of relapsing forms of multiple sclerosis (MS). FDA approves the reintroduction of TYSABRI® for the treatment of relapsing forms of MS. Biogen Idec acquires Fumapharm AG and consolidates control of an oral immunomodulatory compound. Biogen Idec acquires Conforma Therapeutics and expands oncology pipeline and research capabilities. Biogen Idec sells the worldwide rights to AMEVIVE® (alefacept) to Astellas Pharma US. FDA approves RITUXAN® for the treatment of moderate-to-severe rheumatoid arthritis (RA). * 2005: Biogen Idec and PDL BioPharma form global alliance to develop three Phase II antibody products. Biogen Idec and Elan voluntarily suspend the marketing and commercial distribution of TYSABRI® and inform physicians to suspend dosing until further notification. The companies also suspend dosing in all ongoing clinical trials. * 2004: Construction of the San Diego Research and Corporate Campus completed. FDA grants accelerated approval for TYSABRI® for relapsing forms of MS. The approval was based on Priority Review of one-year data from two Phase III studies. * 2003: In June 2003, Biogen and IDEC Pharmaceuticals announce their agreement to merge. This merger is finalized in November 2003, creating Biogen Idec (NASDAQ:BIIB), a global biotechnology leader with products and capabilities in oncology, neurology and immunology. FDA approves AMEVIVE® (alefacept) for the treatment of adult patients with moderate-to-severe chronic plaque psoriasis. Biogen breaks ground on a large-scale manufacturing plant in Denmark. * 2002: Biogen's 90,000-liter large-scale manufacturing plant in Research Triangle Park, N.C., becomes operational. FDA approves ZEVALIN® for the treatment of certain types of B-cell NHL - the first radioimmunotherapy to gain approval as a cancer therapeutic. * 2000: Biogen and Elan Corporation, plc announce collaboration on development and commercialization of the drug candidate ANTEGREN® (natalizumab) in MS and Crohn's disease indications. This product later becomes known as TYSABRI®. * 1999: Development of Antova, an immune system regulator, is halted. * 1997: European marketing of Avonex begins. * 1996: Biogen begins marketing Avonex in the United States. * 1995: FDA approves Avonex for the treatment of relapsing forms of multiple sclerosis. * 1994: James R. Tobin is hired as president and COO; development of Hirulog is halted and the resulting write offs lead to net loss of $4.9 million. * 1989: Company has regained control of 90 percent of its original patents; first full-year profit is posted. * 1985: James L. Vincent is hired as CEO and launches a radical restructuring. * 1984: Company posts $100 million in losses and nears bankruptcy; Gilbert exits from CEO position. * 1983: Biogen goes public. * Early 1980s:Company establishes a global R & D network with operations in Zurich, Geneva, Belgium, Germany, and the United States. * 1978: Walter H. Gilbert founds Biogen Inc. 



On June 7, 2007 - Biogen Idec (NASDAQ: BIIB) announced today that Marijn E. Dekkers, Ph.D., President and Chief Executive Officer (CEO) of Thermo Fisher Scientific, has been elected to the Biogen Idec Board of Directors. The election took place at the company's annual shareholder meeting on May 31, 2007.

On June 3, 2007 - Biogen Idec (NASDAQ: BIIB) announced today that data presented at the 43rd American Society of Clinical Oncology (ASCO) annual meeting showed that adding Zevalin® (Ibritumomab tiuxetan) radioimmunotherapy to a short course first-line treatment followed by rituximab weekly for four weeks doubled the rate of complete response in patients with follicular lymphoma, from 44 percent with a standard treatment regimen to 88 percent. Additionally, the response rate (complete and partial responses) for patients in the study was 100 percent based on PET scan assessment. June 3 is the 154th day of the year (155th in leap years) in the Gregorian calendar. ...

On May 29, 2007 -- Biogen Idec Inc. (NASDAQ: BIIB) today announced that its Board of Directors has authorized a $3 billion share repurchase through a modified "Dutch Auction" tender offer. The offer, which commences tomorrow, for approximately 57 million shares represents about 16% of Biogen Idec's currently outstanding common stock. May 29 is the 149th day of the year (150th in leap years) in the Gregorian calendar. ...

On March 29, 2006, Biogen Idec and Elan announced that they had re-initiated clinical dosing of TYSABRI monotherapy in a safety extension study program in multiple sclerosis (MS). Patients who previously participated in the Phase III MS trials and subsequent safety evaluation are eligible to be screened for entry in this open label multi-center study. is the 88th day of the year (89th in leap years) in the Gregorian calendar. ... Year 2006 (MMVI) was a common year starting on Sunday (link displays full 2006 calendar) of the Gregorian calendar. ...

On March 8, 2006, the Peripheral and Central Nervous System Drugs Advisory Committee of the FDA voted unanimously to recommend reintroduction of TYSABRI as a treatment for relapsing forms of MS. is the 67th day of the year (68th in leap years) in the Gregorian calendar. ... Year 2006 (MMVI) was a common year starting on Sunday (link displays full 2006 calendar) of the Gregorian calendar. ...

On February 28, 2005, Biogen Idec and marketing partner Elan Pharmaceuticals voluntarily suspended marketing of their product TYSABRI (natalizumab), and also suspended dosing in all ongoing clinical trials. TYSABRI had been approved in the US in November 2004 for treatment of patients with relapsing remitting multiple sclerosis (MS). February 28 is the 59th day of the year in the Gregorian calendar. ... Year 2005 (MMV) was a common year starting on Saturday (link displays full calendar) of the Gregorian calendar. ... Élan Corporation plc (NYSE: ELN), (LSE: ELA) is a major drugs firm based in Athlone, County Westmeath, Ireland. ...

The two companies announced the suspension after two participants involved in one study were diagnosed with a severe brain condition, progressive multifocal leukoencephalopathy (PML), after two years of combination therapy with AVONEX, another Biogen Idec product. One of those two patients died. Subsequently, another patient who had previously died in a separate clinical trial of TYSABRI in patients with Crohns Disease was re-evaluated as having had PML. In total, 3 cases of PML were identified, of which 2 cases were fatal. PML may refer to: Piss Myself Laughing, a slang term used on the internet and text talk. ... Crohns disease is a chronic inflammatory disease of the alimentary tract and it can involve any part of it - from the mouth to the anus. ...

Biogen Idec stock lost more than 40% of its value when the drug suspension news was released on February 28, 2005.

External links

  Results from FactBites:
Biogen Idec - Wikipedia, the free encyclopedia (760 words)
Biogen Idec is a member of the SandP 500, SandP 1500, and NASDAQ-100.
Biogen is headquartered in Kendall Square in Cambridge, Massachusetts, and operates research and development facilities in Cambridge and San Diego.
Biogen Idec maintains its international headquarters in Zug, Switzerland, and operates an International regulatory and clinical center of excellence in Maidenhead, UK.
Biogen Idec profits drop 26% - The Boston Globe (455 words)
Biogen Idec Inc.'s third-quarter profits dropped 26 percent compared to the previous year amid charges from its 2003 merger and expenses from a layoff begun in September.
Biogen and its Irish partner, Elan Corp., withdrew Tysabri and disclosed the drug may heighten the risk of contracting a rare disease of the central nervous system.
Biogen Idec predicted it would generate earnings per share next year, excluding unusual items, of $1.95 to $2.10, compared to a consensus of Wall Street analysts that predicts the company to generate $1.63 for the current year.
  More results at FactBites »



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