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Encyclopedia > Bile acid sequestrant

In Pharmacology (in Greek: pharmacon is drug, and logos is science) is the study of how chemical substances interfere with living systems. If these substances have medicinal properties, they are referred to as pharmaceuticals. The field encompasses drug composition, drug properties, interactions, toxicology, and desirable effects that can be used in... pharmacology, bile acid sequestrants a group of medication used for binding Bile is also another name for Belenus, a god in Brythonic mythology. Bile (or gall) is a bitter, greenish-yellow alkaline fluid secreted by the liver of many vertebrates. It is stored in the gallbladder between meals and upon eating is discharged into the duodenum where it aids the process... bile in the For the Physics term GUT, please refer to Grand unification theory The gastrointestinal or digestive tract, also referred to as the GI tract or the alimentary canal or the gut, is the system of organs within multicellular animals which takes in food, digests it to extract energy and nutrients, and... gastrointestinal tract. Its uses are the treatment of Hypercholesterolemia (literally: high blood cholesterol) is the presence of high levels of cholesterol in the blood. It is not a disease but a metabolic derangement that can be secondary to many diseases and can contribute to many forms of disease, most notably cardiovascular disease. Signs and symptoms Elevated cholesterol does... hypercholesterolemia and prevention of An itch (Latin: pruritus) is a sensation felt on an area of skin that makes a person or animal want to scratch it. Mechanism The central chemical in itch is histamine, a molecule released by mast cells in the skin. Histamine is the chemical that causes the itch and reddening... pruritus (itch) in patients with chronic The liver is an organ in vertebrates including humans. It plays a major role in metabolism and has a number of functions in the body including detoxification, glycogen storage and plasma protein synthesis. It also produces bile which is important for digestion. Medical terms related to the liver often start... liver disease or Diarrhea in American English, (spelled diarrhoea elsewhere) is a condition in which the sufferer has frequent and watery bowel movements (from the ancient Greek word διαρροή = leakage). This condition can be a symptom of injury, disease or foodborne illness and is usually accompanied by... diarrhea.


Two drugs are members of this class; both are synthetic resins:

  • Cholestyramine (Questran®, Questran Light®) is a bile acid sequestrant, which binds bile in the gastrointestinal tract to prevent its reabsorption. It is primarily used to treat hypercholesterolemia, but can also used to treat the pruritus, or itching, that often occurs during liver failure due to the livers... Cholestyramine (Questran®)
  • Colestipol (Colestid®)

Use of these agents has decreased markedly since the introduction of Lovastatin, the first statin to be marketed The statins form a class of hypolipidemic agents. They are used as pharmaceuticals to lower cholesterol levels in patients at risk for cardiovascular disease because of hypercholesterolemia. Members The statins are (brand names in countries other than the US can be different): atorvastatin... statins. They are occasionally used as an adjunctive to statins, as the combination of Lovastatin, the first statin to be marketed The statins form a class of hypolipidemic agents. They are used as pharmaceuticals to lower cholesterol levels in patients at risk for cardiovascular disease because of hypercholesterolemia. Members The statins are (brand names in countries other than the US can be different): atorvastatin... statins and In pharmacology, the fibrates are a class of amphipathic carboxylic acids. They are used for a range of metabolic disorders, mainly hypercholesterolemia (high cholesterol), and are therefore hypolipidemic agents. Members Fibrates prescribed commonly are: Clofibrate (largely obsolete due to side-effect profile, e.g. gallstones) Gemfibrozil (e.g. LopidŽ) Fenofibrate... fibrates is thought to increase the likelihood of developing Rhabdomyolysis is the breakdown of skeletal muscle due to injury. The injury can be from physical damage to the muscle, but significant cases of rhabdomyolysis are more commonly due to high fever or hyperthermia, metabolic disorders, excessive exertion, convulsions, choreoathetosis, muscle trauma, flow of electric current through the body or... rhabdomyolysis.


  Results from FactBites:
 
Bile Acid Sequestrants, medications to lower cholesterol on MedicineNet.com (524 words)
Bile acid sequestrants such as cholestyramine (Questran), colestipol (Colestid), and colesevelam (Welchol) are medications for lowering LDL cholesterol.
Bile acid sequestrants bind bile acids in the intestine and cause more of the bile acids to be excreted in the stool.
Therefore, bile acid sequestrants used alone are not as effective as statins in lowering LDL cholesterol.
Bile - Wikipedia, the free encyclopedia (375 words)
salts are steroid compounds (deoxycholic and cholic acid), often conjugated with glycine and taurine, and act to some extent as a detergent, helping to emulsify fats (increasing surface area to help enzyme action), and thus aid in their absorption in the small intestine.
Since bile increases the absorption of fats, it is an important part of the absorption of the fat-soluble vitamins: A, D, E, and K.
Yellow bile and fl bile were two of the four vital fluids or humours of ancient and medieval medicine; for example, melancholia was believed to be caused by a bodily surplus of fl bile.
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