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Encyclopedia > Bemegride
Bemegride
Systematic (IUPAC) name
4-Ethyl-4-methyl-2,6-piperidinedione
Identifiers
CAS number 64-65-3
ATC code  ?
PubChem  ?
Chemical data
Formula C8H13NO2 
Mol. mass 155.20
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

? Image File history File links No higher resolution available. ... IUPAC nomenclature is a system of naming chemical compounds and of describing the science of chemistry in general. ... CAS registry numbers are unique numerical identifiers for chemical compounds, polymers, biological sequences, mixtures and alloys. ... The Anatomical Therapeutic Chemical Classification System is used for the classification of drugs. ... PubChem is a database of chemical molecules. ... A chemical formula (also called molecular formula) is a concise way of expressing information about the atoms that constitute a particular chemical compound. ... General Name, Symbol, Number carbon, C, 6 Chemical series nonmetals Group, Period, Block 14, 2, p Appearance black (graphite) colorless (diamond) Standard atomic weight 12. ... General Name, Symbol, Number hydrogen, H, 1 Chemical series nonmetals Group, Period, Block 1, 1, s Appearance colorless Atomic mass 1. ... General Name, Symbol, Number nitrogen, N, 7 Chemical series nonmetals Group, Period, Block 15, 2, p Appearance colorless gas Standard atomic weight 14. ... General Name, Symbol, Number oxygen, O, 8 Chemical series nonmetals, chalcogens Group, Period, Block 16, 2, p Appearance colorless (gas) very pale blue (liquid) Standard atomic weight 15. ... The molecular mass (abbreviated MM) of a substance, formerly also called molecular weight and abbreviated as MW, is the mass of one molecule of that substance, relative to the unified atomic mass unit u (equal to 1/12 the mass of one atom of carbon-12). ... In pharmacology, bioavailability is used to describe the fraction of an administered dose of medication that reaches the systemic circulation, one of the principal pharmacokinetic properties of drugs. ... Drug metabolism is the metabolism of drugs, their biochemical modification or degradation, usually through specialized enzymatic systems. ... It has been suggested that Effective half-life be merged into this article or section. ... Excretion is the process of eliminating waste products of metabolism and other materials that are of no use. ... The pregnancy category of a pharmaceutical agent is an assessment of the risk of fetal injury due to the pharmaceutical, if it is used as directed by the mother during pregnancy. ...

Legal status
Routes  ?

Bemegride is a CNS stimulant and antidote for barbiturate poisoning. As a stimulant is approximately as potent as phendimetrazine or pemoline. The regulation of therapeutic goods, that is drugs and therapeutic devices, varies by jurisdiction. ... In pharmacology and toxicology, a route of administration is the path by which a drug, fluid, poison or other substance is brought into contact with the body 1. ... Phendimetrazine (Bontril®) is a weight loss medication. ... Pemoline is a medication for Attention-deficit hyperactivity disorder (ADHD). ...


Bemegride is also known as Megimide.


John Bodkin Adams case

For more details, please see - John_Bodkin_Adams#Gertrude_Hullett.

Bemegride is noted in legal history as the drug suspected serial killer John Bodkin Adams failed to prescribe to his patient Gertrude Hullett. She died of a barbiturate overdose on 23 July 1956. John Bodkin Adams, (January 21, 1899–July 4, 1983) was a general practitioner in Eastbourne cleared of murdering one of his patients. ... Serial killers are individuals who have a history of multiple slayings of victims who were usually unknown to them beforehand. ... John Bodkin Adams, (January 21, 1899–July 4, 1983) was a general practitioner in Eastbourne cleared of murdering one of his patients. ... Gertrude Bobby Hullett (?? ?? 1906 - 23 July 1956), was a resident of Eastbourne and patient of the suspected serial killer John Bodkin Adams. ... July 23 is the 204th day (205th in leap years) of the year in the Gregorian calendar, with 161 days remaining. ... 1956 (MCMLVI) was a leap year starting on Sunday of the Gregorian calendar. ...


  Results from FactBites:
 
Discriminative stimulus properties of pentylenetetrazol and bemegride: some generalization and antagonism tests. (279 words)
The bemegride discriminative stimulus generalized to PTZ (20mg/kg) and was antagonized by chlordiazepoxide (10 mg/kg).
Bemegride and cocaine generalized to the PTZ discriminative stimulus in a dose-dependent manner, but d-amphetamine, methylphenidate, and nicotine did not.
Since bemegride and PTZ are convulsants at higher doses, the discriminative stimulus properties of these drugs might be based on a subtle convulsive brain state.
[EEG activation with bemegride in epilepsy diagnosis. 1: Literature review] (281 words)
The administration of bemegride intends the activation of epileptiform discharges in the EEG of patients with a disposition for epilepsy.
The result of the bemegride test is influenced by sex, type of seizures, age and alcohol intake.
In our opinion, the bemegride test is contraindicated in patients with established epilepsy (epileptic seizures respectively) or in cases in whom the occurrence of epileptic seizures is probable.
  More results at FactBites »

 
 

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