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Encyclopedia > Basophil granulocyte
Basophil granulocyte
Basophil granulocyte
Basophil
Basophil

Basophils are the least common of the granulocytes, representing about 0.01% to 0.3% of circulating leukocytes (white blood cells). They contain large cytoplasmic granules which obscure the cell nucleus under the microscope. However, when unstained, the nucleus is visible and it usually has 2 lobes. The mast cell, a cell in tissues, has many similar characteristics. For example, both cell types store histamine, a chemical that is secreted by the cells when stimulated in certain ways (histamine causes some of the symptoms of an allergic reaction). Like all circulating granulocytes, basophils can be recruited out of the blood into a tissue when needed. An anterior pituitary basophil is a type of cell in the anterior pituitary which manufactures hormones. ... Image File history File links PBBasophil. ... Image File history File links Basophil. ... Image File history File links Basophil. ... Eosinophil granulocyte Basophil granulocyte Granulocytes are a category of white blood cells characterised by the presence of granules in their cytoplasm. ... White Blood Cells is also the name of a White Stripes album. ... Organelles. ... HeLa cells stained for DNA with the Blue Hoechst dye. ... Robert Hookes microscope (1665) - an engineered device used to study living systems. ... Microscopy is any technique for producing visible images of structures or details too small to otherwise be seen by the human eye, using a microscope or other magnification tool. ... Mast cells A mast cell (or mastocyte) is a resident cell of areolar connective tissue (loose connective tissue) that contains many granules rich in histamine and heparin. ... Drawing of the structure of cork as it appeared under the microscope to Robert Hooke from Micrographia which is the origin of the word cell being used to describe the smallest unit of a living organism Cells in culture, stained for keratin (red) and DNA (green) The cell is the... Biological tissue is a collection of interconnected cells that perform a similar function within an organism. ... This article or section does not cite any references or sources. ... Allergy is an abnormal reaction to a substance foreign to the body that is acquired, predictable and rapid. ... Human blood smear: a - erythrocytes; b - neutrophil; c - eosinophil; d - lymphocyte. ...


Secretions

When activated, basophils degranulate to release histamine, proteoglycans (e.g. heparin and chondroitin), and proteolytic enzymes (e.g. elastase and lysophospholipase). They also secrete lipid mediators like leukotrienes, and several cytokines. Histamine and proteoglycans are pre-stored in the cell's granules while the other secreted substances are newly generated. Each of these substances contributes to inflammation. Recent evidence suggests that basophils are an important source of the cytokine, interleukin-4, perhaps more important than T cells. Interleukin-4 is considered one of the critical cytokines in the development of allergies and the production of IgE antibody by the immune system. There are other substances that can activate basophils to secrete which suggests that these cells have other roles in inflammation.[1] The degranulation process in a Mast cell. ... This article or section does not cite any references or sources. ... Proteoglycans represent a special class of glycoprotein that are heavily glycosylated. ... Heparin, a highly sulfated glycosaminoglycan is widely used as an injectable anticoagulant and has the highest negative charge density of any known biological molecule. ... Chondroitin is an ingredient found commonly in dietary supplements. ... Proteases (proteinases, peptidases or proteolytic enzymes) are enzymes that break peptide bonds between amino acids of proteins. ... Protein Crystal Growth Porcine Elastase In molecular biology, elastase is an enzyme from the class of proteases (or better peptidases) that break down proteins. ... Some common lipids. ... Leukotrienes are autocrine and paracrine eicosanoid lipid mediators derived from arachidonic acid by 5-lipoxygenase. ... Cytokines are a group of proteins and peptides that are used in organisms as signaling compounds. ... Interleukin-4, abreviated IL-4, is a lymphokine that stimulates the proliferation of activated B-cells and T-cells, among other effects. ... T cells are a subset of lymphocytes that play a large role in the immune response. ... IGE (Internet Gaming Entertainment) is the largest MMORPG services company world-wide, with offices in Los Angeles, Hong Kong, and Miami. ...


Basopenia (a low basophil count) is difficult to demonstrate as the normal basophil count is so low; it has been reported in association with autoimmune urticaria (a chronic itching condition). Basophilia is also uncommon but may be seen in some forms of leukaemia or lymphoma.


References

  1. ^ Janeway CA, Jr. et al (2001). Immunobiology., 5th ed., Garland Publishing. (electronic full text via NCBI Bookshelf) ISBN 0-8153-3642-X. 

Charles Alderson Janeway, Jr. ... Image File history File links Question_book-3. ...

Additional images


  Results from FactBites:
 
Basophil granulocyte - Wikipedia, the free encyclopedia (227 words)
Basophils are the least common of the granulocytes, representing about 1% of circulating leukocytes.
Like all circulating granulocytes, basophils can be recruited out of the blood into a tissue when needed.
Recent evidence suggests that basophils are an important source of the cytokine, interleukin-4, perhaps more important than T cells.
Granulocyte - Wikipedia, the free encyclopedia (166 words)
Granulocytes are a category of white blood cells characterised by the presence of granules in their cytoplasm.
Their names are derived from their staining characteristics; for example, the most abundant granulocyte is the neutrophil granulocyte, which has neutrally-staining cytoplasmic granules.
A granuloma is a tumor containing granulocytes, and a "granulomatosis" is a necrotizing granuloma.
  More results at FactBites »

 
 

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