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Encyclopedia > Autosplenectomy

An autosplenectomy occurs when a disease damages the spleen to such an extect that it is non-functioning and so equivalent to the spleen having been surgically removed (splenectomy). This may occur in sickle cell anaemia and spherocytosis.

Absence of effective splenic function (asplenia) is associated with increased risks of overwhelming post splenectomy infection.

  Results from FactBites:
Sickle-cell disease - Wikipedia, the free encyclopedia (2144 words)
This autosplenectomy increases the risk of infection from encapsulated organisms; preventive antibiotics and vaccinations are recommended for those with such asplenia.
Bone is also a common target of vasoocclusive damage, especially when the bone is particularly weight-bearing.
Overwhelming post (auto)splenectomy infection - due to functional asplenia, caused by encapsulated organisms such as Streptococcus pneumoniae and Haemophilus influenzae.
  More results at FactBites »



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