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Encyclopedia > Argentine hemorrhagic fever
Argentine hemorrhagic fever
Classifications and external resources
ICD-10 A96.0
ICD-9 078.7
DiseasesDB 31900
?
Junín virus
Virus classification
Group: Group V ((-)ssRNA)
Family: Arenaviridae
Genus: Arenavirus
Species

Junín virus
The International Statistical Classification of Diseases and Related Health Problems (commonly known by the abbreviation ICD) is a detailed description of known diseases and injuries. ... The following codes are used with International Statistical Classification of Diseases and Related Health Problems. ... // A00-A79 - Bacterial infections, and other intestinal infectious diseases, and STDs (A00-A09) Intestinal infectious diseases (A00) Cholera (A01) Typhoid and paratyphoid fevers (A010) Typhoid fever (A02) Other Salmonella infections (A03) Shigellosis (A04) Other bacterial intestinal infections (A040) Enteropathogenic Escherichia coli infection (A045) Campylobacter enteritis (A046) Enteritis due to Yersinia... The International Statistical Classification of Diseases and Related Health Problems (commonly known by the abbreviation ICD) is a detailed description of known diseases and injuries. ... The following is a list of codes for International Statistical Classification of Diseases and Related Health Problems. ... The Diseases Database is a free website that provides information about the relationships between medical conditions, symptoms, and medications. ... Viruses can be classified in several ways, such as by their geometry, by whether they have envelopes, by the identity of the host organism they can infect, by mode of transmission, or by the type of disease they cause. ... An RNA virus is a virus that either uses RNA as its genetic material, or whose genetic material passes through an RNA intermediate during replication. ... Arenavirus is a genus of virus. ... Arenavirus is a genus of virus. ...

Argentine hemorrhagic fever, known locally as mal de los rastrojos, is a hemorrhagic fever and zoonotic infectious disease occurring in Argentina. It is caused by the Junín virus (an arenavirus, closely related to the Machupo virus, causative agent of Bolivian hemorrhagic fever). Its vector is a species of rodent, the corn mouse (Calomys musculinus). Viral hemorrhagic fevers are a group of illnesses that are caused by several distinct families of viruses: Arenavirus, Filoviridae, Bunyaviridae and Flavivirus. ... Zoonosis (pronounced as zoo-on-no-sis) is any infectious disease that may be transmitted from animals, both wild and domestic, to humans. ... In medicine, infectious disease or communicable disease is disease caused by a biological agent such as by a virus, bacterium or parasite. ... Arenavirus is a genus of virus. ... Etiology (alternately aetiology, aitiology) is the study of causation. ... Species Machupo virus Bolivian hemorrhagic fever (BHF), also known as black typhus or Machupo virus, is a hemorrhagic fever and zoonotic infectious disease occurring in Bolivia. ... Traditionally in medicine, a vector is an organism that does not cause disease itself but which spreads infection by conveying pathogens from one host to another. ... Suborders Sciuromorpha Castorimorpha Myomorpha Anomaluromorpha Hystricomorpha Rodentia is an order of mammals (Mammalia). ...


The endemic area of AHF covers approximately 150,000 km², compromising the provinces of Buenos Aires, Córdoba, Santa Fe and La Pampa, with an estimated risk population of 5 million. Square kilometre (US spelling: Square kilometer), symbol km², is an SI unit of surface area. ... Argentina is subdivided in 23 provinces (Spanish: provincias, singular - provincia) and 1 federal district (capital federal). ... The Buenos Aires province (IPA: , Spanish: Provincia de Buenos Aires) is the wealthiest and most populated province of Argentina. ... Córdoba is a province of Argentina, located in the center of the country. ... Santa Fe is a province of Argentina, located in the north of the country. ... La Pampa is a province of Argentina, located in the Pampas in the centre of the country. ...


The vector, a small rodent known locally as ratón maicero, suffers from chronic asymptomatic infection, and spreads the virus through its saliva and urine. Infection is produced through contact of skin or mucous membranes, or through inhalation of infected particles. It is found mostly in people who reside or work in rural areas; 80% of the affected are males between 15 and 60 years of age. The term symptom (from the Greek syn = con/plus and pipto = fall, together meaning co-exist) has two similar meanings in the context of physical and mental health: Strictly, a symptom is a sensation or change in health function experienced by a patient. ... Saliva, often informally known as spit, is the moist, clear, and usually somewhat frothy substance produced in the mouths of some animals, including humans. ... To meet Wikipedias quality standards, this article or section may require cleanup. ...


AHF is a grave accute disease which may progress to recovery or death in 1 to 2 weeks. The incubation time of the disease is between 10 and 12 days, after which the first symtomps appear: fever, headaches, weakness, loss of appetite and will. These intensify less than a week later, forcing the infected to lie down, and producing stronger symptoms such as vascular, renal, hematological and neurological alterations. This stage lasts about 3 weeks.


If untreated, the mortality of AHF reaches 15–30%. The specific treatment includes plasma of recovered patients, which, if started early, is extremely effective and reduces mortality to 1%. Ribavirin has also shown some promise in treating arenaviral diseases. Blood plasma is the liquid component of blood, in which the blood cells are suspended. ... Ribavirin (Copegus®; Rebetol®; Ribasphere®; Vilona®,Virazole®, also generics from Sandoz, Teva, Warrick) is an anti-viral drug which is active against a number of DNA and RNA viruses. ...


The disease was first detected in the 1950s in the Junín Partido in Buenos Aires, after which its agent, the Junín virus, was named upon its identification in 1958. In the early years, about 1,000 cases per year were recorded, with a high mortality rate (more than 30%). The initial introduction of treatment serums in the 1970s reduced this lethality. Location of the Municipality of Junín in the Buenos Aires province. ...


Vaccine

The Candid #1 vaccine for AHF was created in 1985 by Dr. Julio Barrera Oro, of the Argentine Dr. Julio Maiztegui National Institute of Human Viral Diseases, but commercial laboratories would not produce it. The vaccine was manufactured by the Salk Institute in the United States, and became available in Argentina since 1990. To meet Wikipedias quality standards, this article or section may require cleanup. ... Salk Institute Salk Institute The Salk Institute for Biological Studies is an independent non-profit educational research organization in La Jolla, California. ...


Candid #1 has been applied to adult high-risk population and is 95.5% effective. On 29 August 2006, the Maiztegui Institute obtained certification for the production of the vaccine in Argentina. A vaccination plan is yet to be outlined, but the budget for 2007 allows for 390,000 doses, at AR$8 each (about US$2.6 or 2). The Institute has the capacity to manufacture, in one year, the 5 million doses required to vaccinate the entire population of the endemic area. August 29 is the 241st day of the year in the Gregorian Calendar (242nd in leap years), with 124 days remaining. ... 2006 (MMVI) is a common year starting on Sunday of the Gregorian calendar. ... The Argentine peso (originally established as the nuevo peso argentino or peso convertible) is the currency of Argentina. ... ISO 4217 Code USD User(s) the United States, the British Virgin Islands, East Timor, Ecuador, El Salvador, the Marshall Islands, Micronesia, Palau, Panama, Turks and Caicos Islands, and the insular areas of the United States Inflation 3. ... ISO 4217 Code EUR User(s) European Union; eurozone: Austria, Belgium, Finland, France, Germany, Greece, Republic of Ireland, Italy, Luxembourg, Netherlands, Portugal, Spain; outside eurozone: Andorra, Monaco, San Marino, Vatican City, Montenegro, Kosovo, French Guiana, Réunion, Saint-Pierre et Miquelon, Guadeloupe, Martinique, Mayotte. ...


Since 1991, more than 240,000 people have been vaccinated, achieving a great decrease in the numbers of reported cases (94 suspect and 19 confirmed in 2005).


The Junín vaccine has also shown cross-reactivity with Machupo virus and, as such, has been considered as a potential treatment for Bolivian hemorrhagic fever. Species Machupo virus Bolivian hemorrhagic fever (BHF), also known as black typhus or Machupo virus, is a hemorrhagic fever and zoonotic infectious disease occurring in Bolivia. ...


Sources

  • Argentine Ministry of Health and Environment, 8 October 2006. Argentina fabricará vacuna contra la fiebre hemorrágica.
  • Clarín, 29 September 2006. La vacuna contra el mal de los rastrojos ya se puede elaborar en el país.
  • TodoAmbiente - Infectious diseases.
  • ANLIS. Fiebre hemorrágica argentina.

 
 

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