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Encyclopedia > Amprenavir

Amprenavir (Agenerase®) is a protease inhibitor used to treat HIV. It was approved by the FDA on April 15, 1999, for twice-a-day dosing instead of needing to be taken every eight hours. The convenient dosing came at a price, as the dose required is 1,200mg, delivered in eight very large gel capsules. Production of amprenavir was discontinued by the manufacturer December 31, 2004. Protease inhibitors are a class of medication used to treat or prevent viral infections. ... Human immunodeficiency virus, commonly known by the initialism HIV, formerly known as HTLV-III and lymphadenopathy-associated virus, is a retrovirus that primarily infects vital components of the human immune system such as CD4+ T cells, macrophages and dendritic cells. ... The United States Food and Drug Administration is the government agency responsible for regulating food, dietary supplements, drugs, cosmetics, medical devices, biologics and blood products in the United States. ... April 15 is the 105th day of the year in the Gregorian calendar (106th in leap years). ... 1999 (MCMXCIX) was a common year starting on Friday, and was designated the International Year of Older Persons by the United Nations. ... December 31 is the 365th day of the year (366th in leap years) in the Gregorian Calendar. ... It has been designated the: International Year of Rice (by the United Nations) International Year to Commemorate the Struggle against Slavery and its Abolition (by UNESCO) 2004 World Health Day topic was Road Safety (by World Health Organization) Year of the Monkey (by the Chinese calendar) See the world in...


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Agenerase Online, Description, Chemistry, Ingredients - Amprenavir - RxList Monographs (575 words)
AGENERASE (amprenavir) is an inhibitor of the human immunodeficiency virus (HIV) protease.
Amprenavir is a white to cream-colored solid with a solubility of approximately 0.04 mg/mL in water at 25
Amprenavir exhibited synergistic anti–HIV-1 activity in combination with abacavir, zidovudine, didanosine, or saquinavir, and additive anti–HIV-1 activity in combination with indinavir, nelfinavir, and ritonavir in vitro.
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