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Encyclopedia > Amphiphilic

An amphipathic (a.k.a. amphiphilic) molecule contains both hydrophobic and hydrophilic groups. The hydrophobic group can be a long carbon chain, with the form: CH3(CH2)n, with 4 < n < 16. The hydrophilic group falls into one of the following categories:

  1. Ionic Molecules
    • Anionic (with respect to the charge on the group maintaining hydrophobia). Examples are:
    • Cationic. These are generically bactericidal and hence non-biodegradable.
  2. Amphoteric Molecules. Examples are phospholipids, one of the main constituents of biological membranes: they insulate the cells from the surrounding medium.
  3. Non_Ionic Molecules. A small polymer is grafted onto a hydrophobic segment.
  4. Block Copolymers
  5. Floation additives

See also



  Results from FactBites:
 
United States Patent Application: 0040091546 (15321 words)
Amphiphilic copolymers and the additive target molecules can be mixed in a ratio between about 1:20 to about 20:1 by weight and result in nanoparticles of amphiphilic copolymers with additive target molecule.
The amphiphilic copolymers used in this invention are comprised of blocks of at least two sub-units or with a minimum contour length the equivalent of at least 5 ethylene units and of a given character and a molecular weight of at least 300 g/mole.
In the present case, nanoparticle compositions in which amphiphilic copolymers contain PEO as the water soluble component are used for steric stabilization of a target molecule are desirable to obtain the properties for a pharmaceutical formulation.
Patent 6,814,971 (3671 words)
The invention relates to adjuvants that contain a lecithin, an oil and an amphiphilic surfactant and that are capable of forming a stable oil-in-water emulsion vaccine so as to minimize local reactions to the vaccine in the injected animal.
In another preferred embodiment, two amphiphilic surfactants are used in an adjuvant of the invention, for example a Tween and a Span surfactant.
Amphiphilic surfactants useful in the adjuvant of the invention have HLB values from about 2 to about 20, preferably from about 3 to about 17.
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