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Encyclopedia > Alzheimer disease

Alzheimer's disease (AD) or senile dementia of Alzheimer's type is a neurodegenerative disease which results in a loss of mental functions due to the deterioration of brain tissue. Its exact aetiology (cause) is still unknown, but environmental as well as genetic factors are thought to contribute (mutations in at least four genes predisposing to AD have been identified).


Until the 1960s, the disease was thought to be uncommon, but later it was realized that much of what had been regarded as the normal process of aging was actually the result of this disease.

Contents

Clinical features

The typical visible symptom is progressive and chronic memory loss. Alzheimer's disease is also manifested in behavorial changes, which may include confusion, disorientation, sudden periods of defiance, abusive behavior, or violence, etc. in people who have no previous history of such behavior (rarely, an affected person experiences euphoria). Thus, Alzheimer's disease presents a problem in patient management, as well. Average duration is approximately 10 years.


Pathology

There are several changes found in the brain in AD.

  • The deposition of an abnormal protein outside nerve cells in the form of amyloid. These are called diffuse plaques and amyloid also forms the core of more organized plaques called senile or neuritic plaques.
  • The accumulation of abnormal filaments of protein inside nerve cells in the brain. The protein is called tau and is normally present to stabilise microtubules. In AD, an abnormally phosphorylated form of tau protein accumulates as paired helical filaments. Tau accumulates
    • As masses of filaments inside nerve cell body termed neurofibrillary tangles
    • Inside nerve cell processes in the brain termed neuropil threads
    • Inside nerve cell processes that surround amyloid plaques - termed plaque neurites.
  • Amyloid accumulation in the walls of small blood vessels in the brain. Termed amyloid angiopathy (also called congophilic angiopathy)
  • Diffuse neuropathology, nerve cells and their processes including synapses die and are lost from key brain regions. This results in atrophy of the affected areas and enlargement of the ventricles.
  • Loss of synaptic contacts between neurons. May be related to the regulation of cell adhesion proteins by presenilins. The presenilins have been identified as part of the processing apparatus that produces the amyloid beta protein.

There is also regional involvement of gross atrophy, and enlarged ventricles in the brain. Massive synaptic and dendritic loss is expected. The neurotransmitters serotonin, acetylcholine, norepinephrine, and somatostatin are at decreased levels. Down syndrome (trisomy 21). The terms "tau-ist" and "ba-ptist" are used (lightheartedly) in scientific publications by Alzheimer's disease researchers. A third protein, alpha synuclein, which has already been shown to be important in Parkinson's disease, has recently been proposed as the etiological candidate, giving rise to the "syn-ners". By 2004, several researchers have come to the conclusion that Alzheimer's disease may be a "triple-protein pathology", wherein interactions among all three lesions are what give rise to Alzheimer's disease, rather than any one of the three.


There is compelling evidence that genetic predispositions underlie the development of Alzheimer's disease. However, the most obviously genetic cases are also the rarest. Most cases identified are 'sporadic' with no clear family history. It is probable that environmental factors have to interact with a genetic susceptibility to cause development of disease. Head injury has been consistently shown to be linked to later development of AD in epidemiological studies. In addition, small cranial diameter has been shown to correlate well with early onset of recognizable symptoms. The most commonly accepted explanation for this last feature is that larger brains simply may have more cells that can afford to be lost. Inheritance of a specific variation of the ApoE gene (epsilon 4) is regarded as a risk factor for development of disease, but large-scale genetic association studies raise the possibility that even this does not indicate susceptibility so much as how early one is likely to develop Alzheimer's. Intriguing work is currently going on investigating the possibility that the regulatory regions of various Alzheimer's associated genes could be important in sporadic Alzheimer's, especially inflammatory activation of these genes.


Studies have not shown strong link with toxins, vitamins, metals or diet, although rabbits fed a high-cholesterol diet in the presence of copper ions in their water did develop amyloid brain lesions and cognitive deficiencies [1] (http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=12920183), [2] (http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=14506299). Likewise, linkage has been found between zinc or copper and reactive oxidative stress contributing to Alzheimer's pathology [3] (http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T0V-483ST4V-1&_coverDate=04%2F30%2F2003&_alid=187240288&_rdoc=1&_fmt=&_orig=search&_qd=1&_cdi=4872&_sort=d&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=c4bdc9c6cb9a59aa2a676e79124856d3), and the amyloid precursor protein has been shown to alter expression in response to metal supplementation and chelation [4] (http://iospress.metapress.com/app/home/contribution.asp?wasp=nntr48wqwp5xnjarpv5m&referrer=parent&backto=issue,10,17;journal,1,29;linkingpublicationresults,1:105656,1), [5] (http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TCR-4B37JCB-2&_coverDate=01%2F15%2F2004&_alid=187240616&_rdoc=1&_fmt=&_orig=search&_qd=1&_cdi=5177&_sort=d&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=f8157cd24891e6a93e263dae23299e96), [6] (http://www.blackwell-synergy.com/openurl?genre=article&sid=nlm:pubmed&issn=0002-8614&date=2003&volume=51&issue=8&spage=1143). Therefore, it is hasty and premature to dismiss any and all environmental effects out of hand. There have been studies that link aluminium to the progression of Alzheimer's, but the results from these studies have not been confirmed and are not widely accepted by Alzheimer's experts.


Rare cases are caused by dominant genes that run in families. These cases often have an early age of onsent. Mutations in presenilin-1 or presenilin-2 genes have been documented in some families. Mutations of presenilin 1 (PS1) lead to the most aggressive form of familial AD (FAD). Evidence from rodent studies suggests that the FAD mutation of PS1 results in impared hippocampal-dependent learning which is correlated with reduced adult neurogenesis in the dentate gyrus (Wang et al, 2004 (http://www.sciencedirect.com/science/article/B6T0F_4CB0G5C_B/1/f88958872d2aed83eebc6cbd76f9341f)). Mutations in the APP gene on chromosome 21 can also cause disease.


Prevalence

Alzheimer's disease is the most frequent reason for dementia in the elderly and affects almost half of all patients with dementia.


2-3% of persons aged 65 show signs of the disease, while 25% or more of persons aged 85 have symptoms of Alzheimer's and an even greater number have some of the pathological hallmarks of the disease without the characteristic symptoms. The proportion of persons with Alzheimer's begins to decrease after age 85 because of the increased mortality due to the disease, and relatively few people over the age of 100 have the disease.


Diagnosis

While expert clinicians who specialize in memory disorders can diagnose AD with an accuracy of 85-90%, a definitive diagnosis of Alzheimer's disease must await an autopsy. Many increasingly sophisticated diagnostic tests are also used(including: brain scans, behavioral tests and testing for genetic predisposition) but these are, at present, used mainly to identify or rule out possible alternative explanations for the symptoms.


Psychological testing generally focuses on memory, attention, abstract thinking, the ability to name objects, and other cognitive functions. However, results of psychological tests do not easily distinguish between Alzheimers Disease and other types of dementia such as normal pressure hydrocephalus. Psychological testing can be helpful in establishing the presence of and severity of dementia. It can also be useful in distinguishing true dementia from temporary (and more treatable) cognitive impairment due to depression or psychosis, which has sometimes been termed pseudodementia.




Prevention

Studies of attempts to cure Alzheimer's after-the-fact have so far been disappointing, while the apparent great success of preventive strategies has so far been uncelebrated and almost unnoticed. Age is the primary risk factor for Alzheimer's. The baby boom is approaching its golden years. Indeed, much of the concern about the solvency of the governmental social safety net is founded on estimates of the costs of caring for baby boomers, assuming that they develop Alzheimer's in the same proportions as earlier generations. Thus making the public aware of the benefits of the available preventive strategies appears a public health concern of high urgency. Indeed, many preventive strategies appear to work far better (or at all) only if begun long before the symptoms of overt Alzheimer's appear. Many studies have indicated that non-steroidal anti-inflammatory drugs (NSAIDs) like aspirin and ibuprofen delay the onset, and lower the ultimate risk, of Alzheimer´s disease. According to population studies, moderate daily dosing over a period of years with non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Advil, Motrin) seems to significantly slow the progress of Alzheimer's, and eventually to dramatically decrease the risk of the disease in those who have not yet developed it. Large daily doses of aspirin also appear to slow the progression towards Alzheimer's, and eventual risk of developing the disease, but to a more moderate degree, and with a larger risk of potentially fatal stomach ulceration. NSAIDs seem to be more effective at preventing or delaying the onset of the disease than treating it once it has progressed to early or full-blown Alzheimer's. Risk-reduction via NSAID use was associated with regular daily use of moderate amounts. Daily users experienced greater risk reduction over time, with some reduction after two years of regular Ibuprofen use, and marked reduction after five or more years. It should be noted that some similar drugs such as acetaminophen, naproxen, and the 'COX2 inhibitors' were found to have no demonstrated effect. This ineffectiveness, and an increase in cardiac events associated with these agents, was reported in various studies in 2004 and highlights the key role of ibuprofen in the original studies showing moderated risk associated with NSAID use. Ibuprofen is also the NSAID with the lowest risk of side effects such as promotion of stomach ulcers. A study (Archives of Neurology 2004; 61:82-88) has reported that the combination of vitamins E and C might, over time, sharply reduce the risk of Alzheimer's disease. Marked reduction (up to 80% risk reduction) was achieved after a period of more than five years, but only if dosage was 500 mg. or more per day of vitamin C plus 400 i.u. per day of vitamin E. Lesser amounts, such as those found in multivitamin pills appeared markedly less effective. Vitamin C without E had no benefit, while large doses of vitamin E without C had only a mild effect. However in one small study, 2000 i.u. per day of vitamin E did appear to delay the progression of early Alzheimer’s by several months. Other evidence suggests that vitamin E becomes a damaging pro-oxidant if given in isolation (without other antioxidants). In isolation vitamin E is not recharged after absorbing a free radical by another antioxidant such as vitamin C or Alpha-Lipoic Acid. Some studies suggest that a ratio of at least 1000 mg. of vitamin C to 400 i.u. of vitamin E is ideal. Recent studies suggest that the gamma form of vitamin E is the most beneficial, especially when taken with oil. In a number of retrospective studies, regular physical exercise has appeared to be inversely related to the development of Alzheimer’s. The Alzheimer's risk of those exercising regularly was half that of the least active. This research is consistent with the observation that virtually all measures designed to promote cardiac fitness and reduce stroke risk also seem to reduce Alzheimer's risk. However in one study, dance appeared to be the only exercise effective in reducing risk. Improved nutritional status of the B vitamin folic acid was found to reduce Alzheimer's incidence in a study of an order of nuns many of whom volunteered to have their mental status assessed and donated their brains for study after death. The "Nun's study" also revealed that nuns who, in life, showed little or no dementia, so long as the brains were free of evidence of stroke, including micro-strokes. Thus avoidance of risk factors for stroke may be a key element in preventing progression to Alzheimer's dementia. The discovery of the co-founding role of stroke supports other research showing that quitting smoking, weight reduction, and avoidance of diabetes all reduce Alzheimer's risk. Diabetes greatly increases Alzheimer's risk, and one factor at work may be that the enzyme charged with removing excess insulin from the blood, the Insulin Degrading Enzyme (IDE) also has the responsibility for removing Beta-amyloid plaques from the brain. Perhaps the excess insulin involved in the pre-diabetic metabolic syndrome, as well as insulin used to treat existing diabetes, may demand more IDE than the body is able to produce. Some evidence suggests that Alzheimer's risk may also be reduced by inclusion of fish in the weekly diet. The spice turmeric seems to reduce Alzheimer's incidents in mice and to dissolve human senile plaques in the test tube. Populations on the Indian subcontinent using turmeric regularly in curry dishes have much lower incidence of Alzheimer's than elsewhere. These factors suggest that inclusion of a bit of turmeric curry spice in the diet may be of value. Presently there are also studies going on testing cholesterol-lowering drugs, so-called statins, like lovastatin, simvastatin etc. as a means of preventing or delaying Alzheimer´s. There seems to be a connection between the cholesterol level inside the brain cells and the deposition of toxic amyloid plaques which make the brain cells die. In addition to lowering cholesterol, the statins may have a beneficial role in reducing inflammation.






Nutrition and Alzheimer's

Some work is being done to investigate the role of raised levels of homocysteine, and possible nutritional prevention or treatment through taking of foods high in B vitamins and antioxidants to control the levels of homocysteine.


This view is supported by Teodoro Bottiglieri, a neuropharmacologist at the Baylor Institute of Metabolic Disease in Dallas, Texas, and Andrew Mc Caddon, a researcher at the University of Wales. (See the Times newspaper, January 31 2004 "Could vitamins help delay the onset of Alzheimer?s?" by Jerome Burne).


See also: Seshadri S, Beiser A, Selhub J, et al. Plasma homocysteine as a risk factor for dementia and Alzheimer's disease. N Engl J Med. 2002 Feb 14;346(7):476-83.




Treatment

There is no cure, although there are drugs which reduce neurotransmitter degradation and alleviate some of the symptoms of the disease.


Acetylcholinesterase inhibitors

Acetylcholinesterase (AChE) inhibition was thought to be important because there is selective loss of forebrain cholinergic neurons as a result of Alzheimer's. AChE-inhibitors reduce the rate at which acetylcholine (ACh) is broken down and hence increase the concentration of ACh in the brain (combatting the loss of ACh caused by the death of the cholinergin neurons). Acetylcholinesterase-inhibitors seemed to modestly moderate symptoms but do not prevent disease progression including cell death.


Examples include:

Recently, a controversy has erupted about cholinesterase inhibitors because a study by Courtney (2004) in the respected medical journal The Lancet has suggested they are ineffective. The pharmaceutical companies dispute the findings of the study.


NMDA antagonists

Recent evidence of the involvement of glutamatergic neuronal excitotoxicity in the aetiology of Alzheimer's disease let to the development and introduction of memantine. Memantine is a novel NMDA receptor antagonist, and has been shown to be moderately clinically efficacious. (Areosa et al., 2004)


Vaccine

There are ongoing tests of an Alzheimer's disease vaccine. This was based on the idea that if you could train the immune system to recognize and attack beta-amyloid placque, the immune system might reverse deposition of amyloid and thus stop the disease. Initial results in animals were promising. However, when the first vaccines were used in humans, brain inflammation occurred in a small fraction of participants, and the trials were stopped. Participants in the halted trials continued to be followed, and some showed lingering benefits in the form of slower progression of the disease. Recent studies in mice continue to show promise that an approach may be found to avoid the inflammation issue. It is hoped that research will provide a better formulation and that in the future it can be of use in families with history of Alzheimer's Disease.


Genetic and population effects

Various gene alleles have been associated with Alzheimer's disease, most notably the apolipoprotein E (ApoE) gene. ApoE normally functions to regulate cholesterol metabolism. In addition, it has recently been discovered that Chinese and North American populations differ significantly in development of full-fledged Alzheimer's from early warning symptoms. Whether the reason for this is genetic, dietary, or social has yet to be investigated.


Social issues

Alzheimer's is considered to be a major public health challenge since the average age of the industrialized world's population is increasing. For this reason, public health dollars spent informing the public of available effective prevention methods may yield disproportionate benefits.


History

The symptoms of the disease as a distinct nosologic entity were first identified by Emil Kraepelin, and the characteristic neuropathology was first observed by Alois Alzheimer in 1906. In this sense, the disease was co-discovered by Kraepelin and Alzheimer, who worked in Kraepelin's laboratory. Because of the overwhelming importance Kraepelin attached to finding the neuropathological basis of psychiatric disorders, Kraepelin made the generous decision that the disease would bear Alzheimer's name (J. Psychiat. Res., 1997, Vol 31, No. 6, pp. 635-643).


Famous Alzheimer's sufferers

See also

Reference

  • Areosa SA, McShane R, Sherriff F. Memantine for dementia. Cochrane Database Syst Rev 2004(4);CD003154.pub2. PMID 15495043 (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list-uids=15495043)
  • Courtney C, Farrell D, Gray R, Hills R, Lynch L, Sellwood E, Edwards S, Hardyman W, Raftery J, Crome P, Lendon C, Shaw H, Bentham P; AD2000 Collaborative Group. Long_term donepezil treatment in 565 patients with Alzheimer's disease (AD2000): randomised double_blind trial. Lancet 2004;363:2105-15. PMID 15220031 (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15220031).

External links

  • Alzheimer's Disease: Molecular Mechanisms (http://www.benbest.com/lifeext/Alzheimer.html)
  • Journal of Alzheimer's Disease (http://www.j-alz.com)
  • Mental Health Matters: Alzheimer's Disease (http://www.mental-health-matters.com/disorders/dis_details.php?disID=5)
  • Psych Forums: Alzheimer's Forum (http://www.psychforums.com/forums/viewforum.php?f=155)
  • Molecule that could stop protein clumping preceding Alzheimer (http://news.bbc.co.uk/2/hi/health/3959381.stm)
  • Alzheimer's Association (http://alz.org)







  Results from FactBites:
 
Alzheimer's disease - Wikipedia, the free encyclopedia (4061 words)
Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive cognitive deterioration together with declining activities of daily living and neuropsychiatric symptoms or behavioral changes.
Eventually, the term Alzheimer's disease was adopted formally in the psychiatric and neurological nomenclature to describe individuals of all ages with the characteristic common symptom pattern, disease course, and neuropathology.
Alzheimer's disease is the most frequent type of dementia in the elderly and affects almost half of all patients with dementia.
understanding Alzheimers Disease (2198 words)
Alzheimers disease is a gradual progression from mild to moderate to severe.
The cause of Alzheimers disease, isolated by the German neurologist Dr. Alois Alzheimer, is the isolation of abnormal clumps and irregular brain cells.
Alzheimers care is a challenge because the slow and unpredictable decline is lengthy and progresses at a different pace.
  More results at FactBites »

 
 

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