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Encyclopedia > Alanine transaminase

Alanine transaminase or ALT is an enzyme (EC that catalyzes the reversible transfer of an amino group from alanine to a-ketoglutarate. It is found in serum and in various bodily tissues but is most commonly associated with the liver. It is also called serum glutamate pyruvate transaminase (SGPT) or alanine aminotransferase (ALAT). wuzz up peeps, hows it hangin? lol, lv ya all! Its alrite thx lol! fuk dis is a borin lesn! lv ya all! every1 reply! i know lol, hows cris? hes alrite, big dick! lol! hi peeps how r u all im alrite thx hun! u? fine who were you... EC numbers (Enzyme Commission numbers) are a numerical classification scheme for enzymes, based on the chemical reactions they catalyze. ... In chemistry, especially in organic chemistry and biochemistry, an amino group is an ammonia-like functional group. ... Alanine is one of the 20 most common natural amino acids. ... Ketoglutaric acid is used for either of two crystalline keto derivatives C5H6O5 of glutaric acid. ... Blood plasma is a component of blood. ... The liver is an organ in vertebrates, including humans. ...

Elevated levels of ALT often suggest the existence of other medical problems such as alcoholic or viral hepatitis, congestive heart failure, liver damage, biliary duct problems, infectious mononucleosis, or myopathy. For this reason, ALT is commonly used as a way of screening for of liver problems. However, elevated levels of ALT do not automatically mean that medical problems exist. Fluctuation of ALT levels is normal over the course of the day, and ALT levels can also increase in response to strenuous physical exercise [1]. Hepatitis is a gastroenterological disease, featuring inflammation of the liver. ... Congestive heart failure (CHF) (also called congestive cardiac failure and heart failure) is the inability of the heart to pump a sufficient amount of blood throughout the body, or requiring elevated filling pressures in order to pump effectively. ... The liver is an organ in vertebrates, including humans. ... A bile duct is any of a number of long tube-like structures that carry bile. ... Infectious mononucleosis (also known as mono, the kissing disease, Pfeiffers disease, and, in British English, glandular fever) is a disease seen most commonly in adolescents and young adults, characterized by fever, sore throat and fatigue. ... In medicine, a myopathy is a neuromuscular disease in which the muscle fibers dysfunction for any one of many reasons, resulting in muscular weakness. ...

When elevated ALT levels are found in the blood, the possible underlying causes can be further narrowed down by measuring other enzymes. For example, elevated ALT levels due to liver-cell damage can be distinguished from biliary duct problems by measuring alkaline phosphatase. Also, myopathy-related ALT levels can be ruled out by measuring creatine kinase enzymes. Hepatocytes make up 60-80% of the cytoplasmic mass of the liver. ... A bile duct is any of a number of long tube-like structures that carry bile. ... Alkaline phosphatase, drawn from PDB 1ANI. Alkaline phosphatase (ALP) (EC 3. ... In medicine, a myopathy is a neuromuscular disease in which the muscle fibers dysfunction for any one of many reasons, resulting in muscular weakness. ... Creatine Kinase Creatine kinase (CK), also known as phosphocreatine kinase or creatine phosphokinase (CPK) is an enzyme (EC 2. ...

For years, the American Red Cross used ALT testing as part of its protocol for method of ensuring the safety of its blood supply by deferring donors with elevated ALT levels. However, the Red Cross recently announced a number of changes to its donor criteria, including its ALT policy. As of July 2003, donors previously disqualified for elevated ALT levels and no other reason may be reinstated as donors by contacting the donor counseling department of their regional Red Cross organization[2]. A WWII-era poster encouraged American women to volunteer for the Red Cross as part of the war effort. ... 2003 (MMIII) is a common year starting on Wednesday of the Gregorian calendar. ...

The enzyme aspartate transaminase (AST) has a similar role to ALT, but this enzyme tends to be found in other tissues, such as the heart, so is not as specific to the liver. Aspartate transaminase (AST) also called Serum Glutamic Oxaloacetic Transaminase (SGOT) or aspartate aminotransferase (ASAT) (EC 2. ... The heart and lungs (from an older edition of Grays Anatomy) The heart (Latin cor) is a hollow, muscular organ that pumps blood through the blood vessels by repeated, rhythmic contractions. ...

See also

  Results from FactBites:
Nitrogen Metabolism and the Urea Cycle (4052 words)
Alanine transaminase has an important function in the delivery of skeletal muscle carbon and nitrogen (in the form of alanine) to the liver.
In the liver alanine transaminase tranfers the ammonia to
This reaction is catalyzed by alanine transaminase, ALT.
  More results at FactBites »



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