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Encyclopedia > Adrafinil
Adrafinil chemical structure
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Adrafinil chemical structure

Adrafinil is a mild central nervous system stimulant drug used to relieve excessive sleepiness and inattention in elderly patients. It is also used off-label by individuals wishing to avoid fatigue, such as night workers or others who need to stay awake and alert for long periods of time. Adrafinil chemical structure diagram I affirm that I (User:Bk0) created this image using ChemDraw and hereby release it for use under the GNU Free Documentation License File links The following pages link to this file: Adrafinil Categories: GFDL images ... Adrafinil chemical structure diagram I affirm that I (User:Bk0) created this image using ChemDraw and hereby release it for use under the GNU Free Documentation License File links The following pages link to this file: Adrafinil Categories: GFDL images ... The vertebrate central nervous system consists of the brain and spinal cord. ... A stimulant is a drug which increases the activity of the sympathetic nervous system and produces a sense of euphoria or awakeness. ... This article needs to be cleaned up to conform to a higher standard of quality. ... Old age consists of ages nearing the average lifespan of human beings, and thus the end of the human life cycle. ... The term off-label refers to the use of a drug for a medical condition other than for which it was officially approved and marketed. ... Fatigue is a feeling of excessive tiredness or lethargy, with a desire to rest, perhaps to sleep. ...


Adrafinil is a prodrug; it is primarily metabolized in vivo to modafinil (Provigil┬«), resulting in nearly identical pharmacologic effects. Unlike modafinil, however, it takes time for the metabolite to accumulate to active levels in the bloodstream. Effects usually are apparent within 45-60 minutes when taken orally on an empty stomach. A prodrug is a pharmacological substance (drug) which is administered in an inactive (or significantly less active) form. ... Santorio Santorio (1561-1636) in his steelyard balance, from Ars de statica medecina, first published 1614 Metabolism (from μεταβολισμος(metavallo), the Greek word for change), in the most general sense, is the ingestion and breakdown of complex compounds, coupled with the liberation of energy, and the consequent generation of waste... In vivo (Latin for (with)in the living). ... Modafinil (Provigil®; Vigicer®; Alertec®) is a stimulant drug produced by the pharmaceutical company Cephalon. ... Pharmacology (in Greek: pharmacon (φάρμακον) is drug, and logos (λόγος) is science) is the study of how chemical substances interact with living systems. ... In anatomy, the stomach (in ancient Greek στόμαχος) is an organ in the alimentary canal used to digest food. ...


Adrafinil, also known by the codename CRL 40028, has as its chemical name 2-(Diphenylmethyl) sulfinyl acetohydroxamic acid. Its molecular formula is C15H15NO3S. The drug's molecular weight is 289.4 daltons.


Adrafinil was discovered in the late 1970s by scientists working with the French pharmaceutical company Group Lafon. The drug was first offered as an experimental treatment for narcolepsy in France in 1986. Later on Lafon scientists developed modafinil as a stand-alone drug because the latter drug was understood to be a more highly selective alpha-1 adrenergic and also featured less in the way of side effects such as stomach pain, skin irritations, inner tension and an increase in liver enzyme levels. Narcolepsy is a neurological condition characterized by severe fatigue, irresistible episodes of sleep and general sleep disorder. ...


Adrafinil does not currently have FDA approval in the United States, although it is used in France and elsewhere in Europe. The drug is marketed by the American pharmaceutical company Cephalon, which acquired Group Lafon in 2001, under the brand name Olmifon. FDA logo The United States Food and Drug Administration (FDA) is the government agency responsible for regulating food (human and animal), dietary supplements, drugs (human and animal), cosmetics, medical devices (human and animal), biologics and blood products in the United States. ... Europe - Wikipedia, the free encyclopedia /**/ @import /skins-1. ... Pharmacology (in Greek: pharmacon is drug, and logos is science) is the study of how chemical substances interfere with living systems. ...


Trivia

The metabolites of Adrafinil contains sulfur, and can easily be detected by a peculiar odour of the urine of the person who has taken it.


External Links

  • Adrafinil: A Novel Vigilance Promoting Agent by Norton W. Milgram, Heather Callahan, and Christina Siwak of the University of Toronto at Scarborough, CNS Drug Reviews, Vol. 5, No. 3, pp. 193-212

  Results from FactBites:
 
Adrafinil - Wikipedia, the free encyclopedia (322 words)
Adrafinil is a mild central nervous system stimulant drug used to relieve excessive sleepiness and inattention in elderly patients.
Adrafinil is a prodrug; it is primarily metabolized in vivo to modafinil (Provigil®), resulting in nearly identical pharmacologic effects.
Adrafinil does not currently have FDA approval in the United States, although it is used in France and elsewhere in Europe.
Erowid Adrafinil Vault : Adrafinil: Amazing Breakthrough in Perception Stimulation (990 words)
Adrafinil acts on the chemical processes of the brain to prevent the loss of alertness and the depression that occurs with increasing age 4,5.
Adrafinil is the founder member of this new generation of drugs, which are known as "eugregorics" (eu=good, gregor=arousal)6.
Adrafinil (sold as Olmifon TM) is an exciting and unique development in the battle against brain aging and the subsequent decline in mental function.
  More results at FactBites »

 
 

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