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Encyclopedia > Acute phase reaction

Acute phase proteins are a class of proteins that are synthetized in the liver in response to inflammation. This response is called the acute phase reaction.


In response to injury, local inflammatory cells (neutrophil granulocytes and macrophages) secrete a number of cytokines into the bloodstream, most notably the interleukins IL-1, IL-6 and IL-11 and TNF_alpha.


The liver responds by producing a large number of acute phase reactants, most notably:



  Results from FactBites:
 
C-Reactive Protein and Erythrocyte Sedimentation Rate in Orthopaedics pg. 13--16 (2324 words)
The clinical use of acute phase proteins is as an aid to diagnosis [15].
Because the acute phase response is relatively non-specific, the value of measuring acute-phase protein concentrations is to assess the extent of inflammation reflecting momentary disease activity.
ESR is an indirect measure of the acute phase reaction.
Tumor necrosis factor - Wikipedia, the free encyclopedia (607 words)
TNF╬▒ is a member of a group of other cytokines that all stimulate the acute phase reaction.
It is a 185 amino acid glycoprotein peptide hormone, cleaved from a 212 amino acid-long propeptide on the surface of macrophages.
On the liver: stimulating the acute phase response, leading to an increase in C-reactive protein and a number of other mediators.
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