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Encyclopedia > Aconitine
Structure of Aconitine
Structure of Aconitine

Aconitine is a highly poisonous alkaloid derived from the aconite plant. It is a neurotoxin that opens TTX-sensitive Na+ channels in the heart and other tissues, and is used for creating models of cardiac arrhythmia. Image File history File links No higher resolution available. ... Image File history File links No higher resolution available. ... The skull and crossbones symbol traditionally used to label a poisonous substance. ... Diagram of Ephedrine An alkaloid, strictly speaking, is a naturally-occurring amine produced by a plant,[1] but amines produced by animals and fungi are also called alkaloids. ... Species About 60: see text Aconitum is a genus of plants belonging to the buttercup family Ranunculaceae. ... A neurotoxin is a toxin that acts specifically on nerve cells – neurons – usually by interacting with membrane proteins and ion channels. ... Tetrodotoxin (anhydrotetrodotoxin 4-epitetrodotoxin, tetrodonic acid, TTX) is a potent neurotoxin, which blocks action potentials in nerves by binding to the pores of the voltage-gated sodium channels in nerve cell membranes. ... Sodium channels (also known as voltage-gated sodium channels) are integral membrane proteins that are localized in and conduct sodium ions (Na+) through a cells plasma membrane. ... The heart and lungs, from an older edition of Grays Anatomy. ... Cardiac arrhythmia is a group of conditions in which the muscle contraction of the heart is irregular or is faster or slower than normal. ...

Aconitine has the chemical formula C34H47NO11, and is soluble in chloroform or benzene, slightly in alcohol or ether, and practically not at all in water. It has an LD50 in mice (intravenously) of 0.12 mg/kg and in rats (orally) of 5.97 mg/kg. CAS number 302-27-2. Solubility refers to the ability for a given substance, the solute, to dissolve in a solvent. ... For the song Chloroform by Spoon, see A Series of Sneaks Chloroform, also known as trichloromethane and methyl trichloride, is a chemical compound with formula CHCl3. ... Benzene, also known as benzol, is an organic chemical compound with the formula C6H6. ... Ethanol, also known as ethyl alcohol, drinking alcohol or grain alcohol, is a flammable, colorless, slightly toxic chemical compound with a distinctive perfume-like odor, and is the alcohol found in alcoholic beverages. ... Diethyl ether, also known as ether and ethoxyethane, is a clear, colorless, and highly flammable liquid with a low boiling point and a characteristic smell. ... Impact of a drop of water Water is a chemical substance that is essential to all known forms of life. ... An LD50 test being administered In toxicology, the LD50 or colloquially semilethal dose of a particular substance is a measure of how much constitutes a lethal dose. ... Feral mouse A mouse (plural mice) is a rodent that belongs to one of numerous species of small mammals. ... Species 50 species; see text *Several subfamilies of Muroids include animals called rats. ... CAS registry numbers are unique numerical identifiers for chemical compounds, polymers, biological sequences and alloys. ...

Probably made most famous by its use in Oscar Wilde's story "Lord Arthur Savile's Crime" (1891). Oscar Fingal OFlahertie Wills Wilde (October 16, 1854 – November 30, 1900) was an Irish playwright, novelist, poet, and short story writer. ...

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  Results from FactBites:
botanical.com - A Modern Herbal | Aconite Herb (3205 words)
Aconitine, the only crystallizable alkaloid, is present to the extent of not more than 0.2 per cent, but to it is due the characteristic activity of the root.
The Aconitines are a group of highly toxic alkaloids derived from various species of Aconite, and whilst possessing many properties in common are chemically distinguishable according to the source from which they are obtained.
Japaconitine is similar in constituents and properties with the Aconitine of A.
Aconitum - Wikipedia, the free encyclopedia (2025 words)
The action of aconitine on the circulation is due to an initial stimulation of the cardio-inhibitory centre in the medulla oblongata (at the root of the vagus nerves), and later to a directly toxic influence on the nerve-ganglia and muscular fibres of the heart itself.
It should however be noted that aconitine may be easily absorbed through the skin, and poisoning may occur through this route simply by picking the leaves without the use of gloves; the toxin in the sap is absorbed through the skin.
Aconitine is a potent neurotoxin that blocks tetrodotoxin-sensitive sodium channels.
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