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Encyclopedia > Acetyldihydrocodeine
Acetyldihydrocodeine
Systematic (IUPAC) name
3-methoxy-6-acetoxy-(5α,6α)-7,8-Didehydro-4,5-epoxy-17-methylmorphinan
Identifiers
CAS number 3861-72-1
ATC code  ?
PubChem 5463874
Chemical data
Formula C20H25NO4 
Mol. mass 343.417 g/mol
Synonyms Acetyldihydrocodeine, Dihydrothebacone, 6-acetyl-7,8-dihydrocodeine
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

? Image File history File links No higher resolution available. ... IUPAC nomenclature is a system of naming chemical compounds and of describing the science of chemistry in general. ... CAS registry numbers are unique numerical identifiers for chemical compounds, polymers, biological sequences, mixtures and alloys. ... The Anatomical Therapeutic Chemical Classification System is used for the classification of drugs. ... PubChem is a database of chemical molecules. ... A chemical formula (also called molecular formula) is a concise way of expressing information about the atoms that constitute a particular chemical compound. ... General Name, Symbol, Number carbon, C, 6 Chemical series nonmetals Group, Period, Block 14, 2, p Appearance black (graphite) colorless (diamond) Standard atomic weight 12. ... General Name, Symbol, Number hydrogen, H, 1 Chemical series nonmetals Group, Period, Block 1, 1, s Appearance colorless Atomic mass 1. ... General Name, Symbol, Number nitrogen, N, 7 Chemical series nonmetals Group, Period, Block 15, 2, p Appearance colorless gas Standard atomic weight 14. ... General Name, Symbol, Number oxygen, O, 8 Chemical series nonmetals, chalcogens Group, Period, Block 16, 2, p Appearance colorless (gas) very pale blue (liquid) Standard atomic weight 15. ... The molecular mass (abbreviated MM) of a substance, formerly also called molecular weight and abbreviated as MW, is the mass of one molecule of that substance, relative to the unified atomic mass unit u (equal to 1/12 the mass of one atom of carbon-12). ... This article or section does not adequately cite its references or sources. ... In pharmacology, bioavailability is used to describe the fraction of an administered dose of unchanged drug that reaches the systemic circulation, one of the principal pharmacokinetic properties of drugs. ... Drug metabolism is the metabolism of drugs, their biochemical modification or degradation, usually through specialized enzymatic systems. ... It has been suggested that Effective half-life be merged into this article or section. ... Excretion is the process of eliminating waste products of metabolism and other materials that are of no use. ... The pregnancy category of a pharmaceutical agent is an assessment of the risk of fetal injury due to the pharmaceutical, if it is used as directed by the mother during pregnancy. ...

Legal status
Routes  ?

Acetyldihydrocodeine is an opiate derivative developed as a cough suppressant and analgesic. It is not commonly used, but has activity similar to other opiates. Acetyldihydrocodeine can be described as the 6-acetyl derivative of dihydrocodeine and is metabolised in the liver by demethylation and deacetylation to produce dihydromorphine. The regulation of therapeutic goods, that is drugs and therapeutic devices, varies by jurisdiction. ... In pharmacology and toxicology, a route of administration is the path by which a drug, fluid, poison or other substance is brought into contact with the body 1. ... In medicine, the term opiate describes any of the narcotic alkaloids found in opium. ... This article or section does not adequately cite its references or sources. ... Dihydrocodeine, also called DHC and Paracodeine and by the brand names of SS Bron, Drocode, Paracodin, Codidol, Didor Continus, Dicogesic, and DF-118 amongst others, is a semi-synthetic opioid analgesic prescribed for postoperative pain, severe dyspnea, or as an antitussive. ... Dihydromorphine is a semi-synthetic opioid invented in Germany in the first years of the twentieth century. ...


Since acetyldihydrocodeine has higher lipophilicity than codeine and is converted into dihydromorphine rather than morphine, it can be expected to be more potent and longer lasting, and also have higher bioavailability than codeine; however its action is still limited by the rate at which liver enzymes demethylate it into dihydromorphine. Side effects are similar to those of other opiates and include itching, nausea and respiratory depression. Codeine (INN) or methylmorphine is an opiate used for its analgesic, antitussive and antidiarrheal properties. ... This article does not adequately cite its references or sources. ... In pharmacology, bioavailability is used to describe the fraction of an administered dose of unchanged drug that reaches the systemic circulation, one of the principal pharmacokinetic properties of drugs. ... An opioid is any agent that binds to opioid receptors found principally in the central nervous system and gastrointestinal tract. ... An itch (Latin: pruritus) is a sensation felt on an area of skin that makes a person or animal want to scratch it. ... For the Beck song, see Nausea (song). ... In medicine, hypoventilation exists when ventilation is inadequate to perform gas exchange. ...


  Results from FactBites:
 
UNDCP - E/NL. 1973/31: Order No.379 of 2 August 1971 - Eighth Am (536 words)
Producers of pharmaceutical preparations containing no narcotic drugs other than codeine, ethylmorphine (dionine), dihydrocodeine (paracodine), codeine nicotinic acid ester (nicocodine), acetyldihydrocodeine or ß -4-morphololinylethylmorphine (pholcodine) may, however, supply samples of such preparations direct to doctors, but shall supply the Narcotic Drugs Control Authority with a monthly statement showing the samples supplied to individual doctors."
Application for import authorizations concerning pharmaceutical preparations not containing narcotic drugs other than codeine, ethylmorphine (dionine), dihydrocodeine (paracodine), codeine nicotinic acid ester (nicocodine), acetyldihydrocodeine or ß -4-morpholinylethylmorphine (pholcodine) need be made only on sheets 1 and 2 of form 7."
The export of pharmaceutical preparations not containing more than 100 mg of codeine, ethylmorphine (dionine), dihydrocodeine (paracodine), codeine nicotinic acid ester (nicocodine), acetyldihydrocodeine or ß -4-morpholinylethylmorphine (pholcodine)per dosage unit and not more than 2.5 per cent in undivided preparations and not containing, in addition, any other narcotic drug, is permitted without the above authorization."
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