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Encyclopedia > Abacavir
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ABC
(1S,cis)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol
Molecular Weight 288.35
Empiric Formula C14H20N6O
ATC code J05AF06
Metabolism Liver
Pregnancy category C (USA)
 ? (Aus)

Abacavir (ABC) is extremely potent reverse transcriptase inhibitor, meant for the treatment of AIDS. ABC is capable of crossing the blood-brain barrier. It has been well tolerated; main side effect being hypersensitivity reactions, which can be dangerous. Jump to: navigation, search Image File history File links Abacavir. ... Jump to: navigation, search See also Avogadros number Atomic mass unit Dalton (unit) External links Learning by Simulations Calculation of Molecular Formulas from Molecular Masses Categories: Chemistry stubs | Mass | Chemical properties ... The Anatomical Therapeutic Chemical Classification System is used for the classification of drugs. ... The pregnancy category of a pharmaceutical agent is an assessment of the risk of fetal injury due to the pharmaceutical, if it is used as directed by the mother. ... Wikinews has news related to this article: Australia Wikitravel guide to Australia Australian Government Entry Portal Australia Photos Commonwealth Government Online Department of Immigration and Multicultural and Indigenous Affairs (DIMIA) DFAT: Country Information Satellite images of Australia (Google Maps) National Library of Australia National Museum of Australia Categories: Oceanic countries... Reverse transcriptase is an enzyme used by all retroviruses and retrotransposons that transcribes the genetic information from the virus or retrotransposon from RNA into DNA, which can integrate into the host genome. ... Jump to: navigation, search The Red Ribbon is the global symbol for solidarity with HIV positive people and those living with AIDS. The Red Ribbon made its public debut when host Jeremy Irons wore it during the 1991 Tony Awards. ... The blood-brain barrier is a physical barrier between the blood vessels in the central nervous system, and most parts of the central nervous system itself. ... Hypersensitivity is the name given to a state in which an immune response damages the bodys own tissues. ...


Strains that are resistant to AZT or 3TC are generally sensitive to abacavir, whereas strains that are resistant to AZT and 3TC are not as sensitive to abacavir. Abacavir is given orally and has a high bio-availability of 83 %. It is metabolised primarily through alcohol dehydrogenase or gluconyl transferase. Zidovudine (INN) or azidothymidine (abbreviated to AZT) is an anti-retroviral drug, the first antiviral treatment to be approved for use against HIV. It is also sold under the names Retrovir and Retrovis, and as an ingredient in Combivir and Trizivir. ... Lamivudine(2-3-dideoxy-3-thiacytidine, 3TC) is a potent reverse transcriptase inhibitor. ... Jump to: navigation, search Alcohol Dehydrogenase Alcohol dehydrogenases are a group of dehydrogenase enzymes that occur in many organisms and facilitate the conversion between alcohols and aldehydes or ketones. ...


This drug is available under the trade name Ziagen (GlaxoSmithKline) and in a combination drug Trizivir (GlaxoSmithKline). Categories: Antivirals | Medicine stubs ... GlaxoSmithKline (GSK) plc is a pharmaceutical, biologicals, and healthcare company. ...


References

  • Antiretroviral Therapy-Investigational NRTIs: HIV Clinical Management Vol. 3. Medscape Inc, 1998
  • HIV Insite Antiretroviral Drug Database; UC Regents, 1999


Antivirals edit
Antiherpesvirus agents edit

{Acyclovir} {Cidofovir} {Docosanol} {Famciclovir} {Foscarnet} {Fomivirsen} {Ganciclovir} {Idoxuridine} {Penciclovir} {Trifluridine} {Valaciclovir} {Valganciclovir} {Vidarabine} Wikipedia does not yet have an article with this exact name. ... Aciclovir (INN) or aciclovir (USAN), marketed as Zovirax®, is one of the main antiviral drugs. ... Cidofovir is an injectable antiviral medication for the treatment of cytomegalovirus (CMV) retinitis in patients with AIDS. It suppresses CMV replication by selective inhibition of viral DNA synthesis. ... Docosanol 10% cream is a topical treatment for recurrent herpes simplex labialis episodes (episodes of cold sores or fever blisters). ... Ganciclovir sodium (Cytovene®) is an antiviral medication used to treat cytomegalovirus (CMV) infections. ... Valaciclovir (INN) or valacyclovir (USAN) is an antiviral drug used in the management of herpes simplex. ... Valganciclovir hydrochloride (Valcyte®) is an antiviral medication used to treat cytomegalovirus infections. ... Jump to: navigation, search Chemical structure of vidarabine Vidarabine is an anti-viral drug which is active against herpes simplex and varicella zoster viruses. ...

Antiinfluenza agents [ ]

{Amantadine} {Oseltamivir} {Rimantidine} {Zanamivir} Jump to: navigation, search Antiviral drugs are a class of medication used specifically for treating viral infections. ... Jump to: navigation, search Amantadine, 1-aminoadamantane, is an antiviral drug that was approved by the FDA in 1976 for the treatment of influenza type A in adults. ... Jump to: navigation, search Oseltamivir is an antiviral drug, a neuraminidase inhibitor used in the treatment and prophylaxis of both influenza A and influenza B. Oseltamivir was the first orally active neuraminidase inhibitor commercially developed. ... Zanamivir is a neuraminidase inhibitor used in the treatment of and prophylaxis of both influenza A and influenza B. Zanamivir was the first neuraminidase inhibitor commercially developed. ...


Antiretrovirals edit

NRTIs edit Jump to: navigation, search Antiretroviral drugs are medications for the treatment of infection by the retrovirus HIV. Different antiretroviral drugs act at various stages of the HIV life cycle. ... Jump to: navigation, search Antiretroviral drugs are medications for the treatment of infection by the retrovirus HIV. Different antiretroviral drugs act at various stages of the HIV life cycle. ...

{Zidovudine} {Didanosine} {Stavudine} {Zalcitabine} {Lamivudine} {Abacavir} Zidovudine (INN) or azidothymidine (abbreviated to AZT) is an antiretroviral drug, the first antiviral treatment to be approved for use against HIV. It is also sold under the names Retrovir and Retrovis, and as an ingredient in Combivir and Trizivir. ... Didanosine (2-3-dideoxyinosine,ddI) differs from other nucleoside analogues, because it does not have any of the regular bases, instead it has hypoxanthine attached to the sugar ring. ... Stavudine (2-3-didehydro-2-3-dideoxythymidine, d4T) is a thymidine analogue active against HIV. It is phosphorylated by cellular kinases into active triphosphate. ... Zalcitabine (2-3-dideoxycytidine, ddC), is a derivative of the naturally existing deoxycytidine, made by replacing the hydroxyl group in position 3 with a hydrogen. ... Lamivudine(2-3-dideoxy-3-thiacytidine, 3TC) is a potent reverse transcriptase inhibitor. ...


NNRTIs edit Jump to: navigation, search Antiretroviral drugs are medications for the treatment of infection by the retrovirus HIV. Different antiretroviral drugs act at various stages of the HIV life cycle. ...

{Nevirapine} {Efavirenz} {Delavirdine} Nevirapine is a controversial AIDS drug. ... DESCRIPTION SUSTIVA® (efavirenz) is a human immunodeficiency virus type 1 (HIV-1) specific, non-nucleoside, reverse transcriptase inhibitor (NNRTI). ...


PIs edit Jump to: navigation, search Antiretroviral drugs are medications for the treatment of infection by the retrovirus HIV. Different antiretroviral drugs act at various stages of the HIV life cycle. ...

{Saquinavir} {Indinavir} {Atazanavir} {Ritonavir} {Nelfinavir} {Amprenavir} {Lopinavir} Saquinavir (Fortovase®, Roche) is a protease inhibitor, used as a component of HIV therapy. ... Categories: Stub ... Ritonavir is a drug from the protease inhibitor class used to treat AIDS. It is manufactured as Norvir® by Abbott Laboratories. ... Jump to: navigation, search Nelfinavir (Viracept®) is an antitretroviral drug used in the treatment of the human immunodeficiency virus (HIV). ...


Other antiviral agents edit

{Fomivirsen} {Imiquimod} {Interferon} {Lamivudine} {Ribavirin} Jump to: navigation, search Antiviral drugs are a class of medication used specifically for treating viral infections. ... Jump to: navigation, search Interferons (IFNs) are natural proteins produced by the cells of the immune systems of most animals in response to challenges by foreign agents such as viruses, bacteria, parasites and tumor cells. ... Lamivudine(2-3-dideoxy-3-thiacytidine, 3TC) is a potent reverse transcriptase inhibitor. ... Ribavirin (Copegus®; Rebetol®) is an anti-viral drug active against a number of DNA and RNA viruses. ...


  Results from FactBites:
 
Ziagen Online, Description, Chemistry, Ingredients - Abacavir Sulfate - RxList Monographs (832 words)
Hypersensitivity to abacavir is a multi-organ clinical syndrome usually characterized by a sign or symptom in 2 or more of the following groups: (1) fever, (2) rash, (3) gastrointestinal (including nausea, vomiting, diarrhea, or abdominal pain), (4) constitutional (including generalized malaise, fatigue, or achiness), and (5) respiratory (including dyspnea, cough, or pharyngitis).
Abacavir sulfate is a white to off-white solid with a solubility of approximately 77 mg/mL in distilled water at 25
Abacavir had synergistic activity in vitro in combination with the nucleoside reverse transcriptase inhibitor (NRTI) zidovudine, the non-nucleoside reverse transcriptase inhibitor (NNRTI) nevirapine, and the protease inhibitor (PI) amprenavir; and additive activity in combination with the NRTIs didanosine, emtricitabine, lamivudine, stavudine, tenofovir, and zalcitabine.
  More results at FactBites »

 
 

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