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Encyclopedia > Aafact

Aafact is a monoclonal purified factor VIII concentrate. It consists of a protein fraction prepared from fresh-frozen human plasma. It is used in cases of acute haemorrhage, pre-operative and post-operative treatment and prophylaxis in haemophilia A patients (congenital factor VIII deficiency) and in patients with an acquired reduction in factor VIII activity. It is available as a powder for infusion for intravenous administration. Factor VIII (FVIII) is an essential clotting factor. ... Haemophilia A (also spelt Hemophilia A or Hæmophilia A) is a blood clotting disorder caused by a mutation of the factor VIII gene, leading to a deficiency in Factor VIII. It is the most common hemophilia. ... An intravenous drip in a hospital Intravenous therapy or IV therapy is the administration of liquid substances directly into a vein. ...


This transfer of a plasma byproduct into the blood stream of a hemophiliac often led to the transmission of diseases such as HIV and hepatitis before purification methods were improved. In the early 1990s, pharmaceutical companies began to produce recombinant synthesized factor products, which now prevent nearly all forms of disease transmission during replacement therapy. Blood plasma is the liquid component of blood, in which the blood cells are suspended. ... Haemophilia or hemophilia is the name of any of several hereditary genetic illnesses that impair the bodys ability to control bleeding. ... Human immunodeficiency virus or HIV is a retrovirus that causes Acquired Immunodeficiency Syndrome (AIDS), a condition in which the immune system begins to fail, leading to life-threatening opportunistic infections. ... Hepatitis is a gastroenterological disease, featuring inflammation of the liver. ... Recombinant proteins are proteins that are produced by different genetically modified organisms following insertion of the relevant DNA into their genome. ...


see also

factor VIII Factor VIII (FVIII) is an essential clotting factor. ...


 
 

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