The ATP-binding cassette (ABC) transporter superfamily of membrane proteins function in the transport of a wide variety of substrates across extra- and intracellular membranes, including metabolic products, lipids and sterols, and drugs. This article or section should include material from Net flux A membrane is a thin, typically planar structure or material that separates two environments. ... Santorio Santorio (1561-1636) in his steelyard balance, from Ars de statica medecina, first published 1614 Metabolism (from μεταβολισμος(metavallo), the Greek word for change), in the most general sense, is the ingestion and breakdown of complex compounds, coupled with the liberation of energy, and the consequent generation of waste... Figure 1: Basic lipid structure. ... Sterols are a subgroup of steroids with a hydroxyl group in the 3-position of the A-ring. ... Many drugs are provided in tablet form. ...
Yet another ABCtransporter, the TAP protein, is critical for the proper functioning of the cellular immune response, as it pumps antigenic polypeptides from the cytoplasm into the endoplasmic reticulum, where they are being loaded onto MHC class I molecules for subsequent presentation on the cell surface.
The initial motion of the ABC cassettes has been dubbed the power stroke, and it is generally assumed that this rearrangement is similar in all ABCtransporters, irrespective of the size of the substrate to be transported or the directionality of the translocation (import or export).
Transport pathway: Accessible from the outside (periplasm), but sealed from the cytoplasm of the cell, a large cavity is buried at the interface of the two membrane-spanning BtuC subunits.
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