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Encyclopedia > ABC transporter

The ATP-binding cassette (ABC) transporter superfamily of membrane proteins function in the transport of a wide variety of substrates across extra- and intracellular membranes, including metabolic products, lipids and sterols, and drugs. This article or section should include material from Net flux A membrane is a thin, typically planar structure or material that separates two environments. ... Santorio Santorio (1561-1636) in his steelyard balance, from Ars de statica medecina, first published 1614 Metabolism (from μεταβολισμος(metavallo), the Greek word for change), in the most general sense, is the ingestion and breakdown of complex compounds, coupled with the liberation of energy, and the consequent generation of waste... Figure 1: Basic lipid structure. ... Sterols are a subgroup of steroids with a hydroxyl group in the 3-position of the A-ring. ... Many drugs are provided in tablet form. ...


References

Dean, Michael. The Human ATP-Binding Cassette (ABC) Transporter Superfamily (http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=mono_001.chapter.137). Bethesda (MD):National Library of Medicine (US), NCBI; 2002 November.


  Results from FactBites:
 
ATP-binding cassette transporter genes - Wikipedia, the free encyclopedia (885 words)
Proteins are classified as ABC transporters based on the sequence and organization of their ATP-binding domain(s), also known as nucleotide-binding folds (NBFs).
ABC transporters may be classified as either half transporters or full transporters.
ABC transporters are known to play a crucial role in the development of multidrug resistance (MDR).
ABC Transporter Architecture (839 words)
Yet another ABC transporter, the TAP protein, is critical for the proper functioning of the cellular immune response, as it pumps antigenic polypeptides from the cytoplasm into the endoplasmic reticulum, where they are being loaded onto MHC class I molecules for subsequent presentation on the cell surface.
The initial motion of the ABC cassettes has been dubbed the power stroke, and it is generally assumed that this rearrangement is similar in all ABC transporters, irrespective of the size of the substrate to be transported or the directionality of the translocation (import or export).
Transport pathway: Accessible from the outside (periplasm), but sealed from the cytoplasm of the cell, a large cavity is buried at the interface of the two membrane-spanning BtuC subunits.
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